Han Han,Alisa Mahieu,Lucas Dantas de Paula et al.
Han Han et al.
Emerging studies highlight the Hippo pathway as an important player in organ size control, tissue homeostasis, regeneration, development, and diseases, but our understanding of its roles and regulations remains incomplete. Our recent work r...
Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing [0.03%]
仿生人类骨髓组织：用于研究造血作用和药物测试的平台
Andrés García-García,Ivan Martin
Andrés García-García
We propose an in vitro 3D culture system combining perfusion bioreactors, scaffolds and human primary cells to engineer fully-humanized, biomimetic and customizable bone marrow tissues. This system could serve as a model to investigate huma...
Genomic studies indicate a novel combination therapy for follicular lymphoma [0.03%]
基因组研究为滤泡性淋巴瘤的组合疗法提供了新的思路
Elisa Oricchio,Hans-Guido Wendel
Elisa Oricchio
Follicular lymphoma (FL) is an incurable form of B-cell lymphoma. Genomic alterations that inactivate RB signaling are surprisingly common in indolent FL. We show that FLs that are positive for phosphorylated RB respond to dual CDK4/BCL2 in...
Mariana Paes Dias,Jos Jonkers
Mariana Paes Dias
Tumors with loss of breast cancer type 1 susceptibility protein (BRCA1) are homologous recombination (HR) deficient and hypersensitive to poly(ADP-ribose) polymerase inhibitors (PARPi). However, these tumors may restore HR and acquire PARPi...
Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma [0.03%]
KRAS突变型肺腺癌的RTK依赖性转移表型的新见解
Mariana Cooke
Mariana Cooke
In a recent study, our group identified RAC guanine nucleotide exchange factors (RAC-GEFs) driving motility signaling in KRAS mutant lung adenocarcinoma cells. The RAC-GEFs FARP1, ARHGEF39 and TIAM2 play fundamental roles in the formation o...
Alizée Vercauteren Drubbel,Benjamin Beck
Alizée Vercauteren Drubbel
Barrett syndrome is a squamo-columnar metaplasia increasing the risk of developing esophageal adenocarcinoma. Recently, we showed that esophageal cells can transdifferentiate into undifferentiated columnar cells in vivo. Here, we discuss ab...
Genome-wide CRISPR screening reveals novel therapeutic targets in RIT1-driven lung cancer [0.03%]
基于CRISPR的基因敲除筛选发现RIT1驱动的肺癌新的治疗靶点
Amanda K Riley,Alice H Berger
Amanda K Riley
In recent work, we performed CRISPR/Cas9 screening in RIT1 (Ras-like in all tissues)-mutant cancer cells. We found that RIT1-mutant cells are vulnerable to loss of mitotic regulators, and mutant RIT1 synergizes with YAP1 (yes-associated pro...
SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy [0.03%]
SPF45/RBM17依赖的剪接及癌症化疗耐药性
Kazuhiro Fukumura,Julian P Venables,Akila Mayeda
Kazuhiro Fukumura
The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resista...
The perfect PTEN - transcriptional regulation by PTEN dictates sarcoma identity [0.03%]
PTEN的完美平衡——PTEN转录调控决定肉瘤身份
Casey G Langdon,Mark E Hatley
Casey G Langdon
Fusion-negative rhabdomyosarcoma (FN-RMS) is molecularly heterogeneous with few universal alterations except for Phosphatase and tensin homolog (PTEN) promoter hypermethylation. We demonstrate that losing Pten in FN-RMS engages an aberrant ...
Interdisciplinary team science to understand and intercept rare cancers [0.03%]
学科交叉团队科学研究罕见癌症的理解与阻击
Stefan Fröhling
Stefan Fröhling
For most rare cancers, precision oncology approaches are not established because these entities are poorly understood and their investigation requires the collaboration of many centers. The MASTER precision oncology network demonstrates tha...