François Ghiringhelli
François Ghiringhelli
Resistance to chemoimmunotherapy is a major issue for cancer care. We recently unravelled the role of mitogen-activated protein kinase (MAPK) to limit the antitumor efficacy of such combination. Inhibitor of MAPK pathway using mitogen-activ...
Gaurav Mendiratta,Michael K Jones,Edward C Stites
Gaurav Mendiratta
Genome sequenced samples from cancer patients helped identify roles of different mutation types and enabled targeted therapy development. However, critical questions like what are the gene mutation rates among the patients? or what genes ar...
Marjorie Lapouge,Sylvain Meloche
Marjorie Lapouge
Identification of dominant, actionable oncogenic signaling pathways is key to guide the development of new targeted treatments for advanced-stage hepatocellular carcinoma (HCC). We have recently unveiled a novel YES-YAP/TAZ signaling axis i...
CircZNF609 as a prototype to elucidate the biological function of circRNA-mRNA interactions [0.03%]
环状RNA-circZNF609通过结合靶mRNA来阐明环状RNA的生物学功能原型作用研究
Manuel Beltran,Francesca Rossi,Irene Bozzoni
Manuel Beltran
Circular RNAs (circRNAs) are expressed and are regulated in many biological processes but little is known about their ability to directly control mRNA homeostasis. We show that circRNA zinc finger protein 609 (circZNF609) interacts with sev...
Han Han,Alisa Mahieu,Lucas Dantas de Paula et al.
Han Han et al.
Emerging studies highlight the Hippo pathway as an important player in organ size control, tissue homeostasis, regeneration, development, and diseases, but our understanding of its roles and regulations remains incomplete. Our recent work r...
Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing [0.03%]
仿生人类骨髓组织：用于研究造血作用和药物测试的平台
Andrés García-García,Ivan Martin
Andrés García-García
We propose an in vitro 3D culture system combining perfusion bioreactors, scaffolds and human primary cells to engineer fully-humanized, biomimetic and customizable bone marrow tissues. This system could serve as a model to investigate huma...
Genomic studies indicate a novel combination therapy for follicular lymphoma [0.03%]
基因组研究为滤泡性淋巴瘤的组合疗法提供了新的思路
Elisa Oricchio,Hans-Guido Wendel
Elisa Oricchio
Follicular lymphoma (FL) is an incurable form of B-cell lymphoma. Genomic alterations that inactivate RB signaling are surprisingly common in indolent FL. We show that FLs that are positive for phosphorylated RB respond to dual CDK4/BCL2 in...
Mariana Paes Dias,Jos Jonkers
Mariana Paes Dias
Tumors with loss of breast cancer type 1 susceptibility protein (BRCA1) are homologous recombination (HR) deficient and hypersensitive to poly(ADP-ribose) polymerase inhibitors (PARPi). However, these tumors may restore HR and acquire PARPi...
Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma [0.03%]
KRAS突变型肺腺癌的RTK依赖性转移表型的新见解
Mariana Cooke
Mariana Cooke
In a recent study, our group identified RAC guanine nucleotide exchange factors (RAC-GEFs) driving motility signaling in KRAS mutant lung adenocarcinoma cells. The RAC-GEFs FARP1, ARHGEF39 and TIAM2 play fundamental roles in the formation o...
Alizée Vercauteren Drubbel,Benjamin Beck
Alizée Vercauteren Drubbel
Barrett syndrome is a squamo-columnar metaplasia increasing the risk of developing esophageal adenocarcinoma. Recently, we showed that esophageal cells can transdifferentiate into undifferentiated columnar cells in vivo. Here, we discuss ab...