Mass spectrometry-based proteomic analysis to characterize cisplatin induced early signaling events in head and neck squamous cell carcinoma [0.03%]
基于质谱的蛋白质组学分析用于表征头颈部鳞状细胞癌中顺铂诱导的早期信号事件
Ankit P Jain,Vivek Ghose,Srijon Munshi et al.
Ankit P Jain et al.
Cisplatin is the commonly used chemotherapeutic drug in treatment of various cancers. However, development of resistance towards cisplatin results in tumor recurrence. Here, we aim to understand the mechanisms of action of cisplatin and eme...
Hypofunction of macrophage chemotaxis contributes to defective efficacy of herceptin in HER2-positive breast cancer patients [0.03%]
巨噬细胞趋化功能低下的确证对HER2阳性乳腺癌患者赫赛汀疗效的影响
Yu Song,Qiao-Chen Geng,Wen-Jing An et al.
Yu Song et al.
Breast cancer was considered as a kind of prone breast tumors with the complicated pathological mechanisms and diverse clinical classifications. In the clinical treatments of HER2-positive tumor patients, HER2 monoclonal antibodies, such as...
Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells [0.03%]
芒果核提取物通过细胞周期阻滞和诱导凋亡抑制肺肿瘤细胞的活力和增殖
Hussah Abdullah Alshwyeh,Warqaa Muhammed Shariff Al-Sheikh,Abdullah Rasedee et al.
Hussah Abdullah Alshwyeh et al.
In this study, we investigated the effects of an ethanolic extract of Mangifera indica L. kernel on the viability and proliferation of human lung cancer cells. We utilized MTT and BrdU cell proliferation assays, morphological assessments, c...
Subramanian Venkatesan,Mihaela Angelova,Jirina Bartkova et al.
Subramanian Venkatesan et al.
Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy num...
Silencing Glypican-1 enhances the antitumor effects of Pictilisib via downregulating PI3K/Akt/ERK signaling in chemo-resistant esophageal adenocarcinoma [0.03%]
沉默Glypican-1通过下调PI3K/Akt/ERK信号通路增强Pictilisib在化疗耐药食管腺癌中的抗肿瘤作用
Akshay Pratap,Andrea Qualman,Hedlund Garrett et al.
Akshay Pratap et al.
Poorly differentiated esophageal adenocarcinoma (PDEAC) has a dismal prognosis. Glypican-1(GPC-1) is known to be upregulated in several cancer types in contrast to healthy tissues, rendering it as a biomarker. Nevertheless, the potential th...
The identification of key genes and pathways in glioblastoma by bioinformatics analysis [0.03%]
生物信息学分析识别胶质母细胞瘤的关键基因和途径
Zahra Farsi,Najaf Allahyari Fard
Zahra Farsi
GBM is the most common and aggressive type of brain tumor. It is classified as a grade IV tumor by the WHO, the highest grade. Prognosis is generally poor, with most patients surviving only about a year. Only 5% of patients survive longer t...
The developmental gene Chordin is amplified and expressed in human cancers [0.03%]
人类癌症中发育基因Chordin的扩增和表达
Eric Sosa,Edward M De Robertis
Eric Sosa
Chordin (CHRD) is a secreted protein important in early development, yet a role for CHRD in human disease has not been identified. In this study we investigated CHRD in cancer and normal adult tissues using the wealth of genome-wide data av...
Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer [0.03%]
巴西前列腺癌患者血浆病毒组的元基因组学见解
Dalila Luciola Zanette,Karoline Brito Caetano Andrade Coelho,Eneas de Carvalho et al.
Dalila Luciola Zanette et al.
Growing evidence suggests that metavirome changes could be associated increased risk for malignant cell transformation. Considering Viruses have been proposed as factors for prostate cancer induction. The objective of this study was to exam...
Therapeutic potential of targeting mirnas to prostate cancer tumors: using psma as an active target [0.03%]
靶向PSMA作为活性位点的mirna在前列腺癌治疗中的潜力研究
Amir Yarahmadi,Romoye Sohan,Brenna McAllister et al.
Amir Yarahmadi et al.
Prostate cancer (PC) is a commonly diagnosed malignancy in men and is associated with high mortality rates. Current treatments for PC include surgery, chemotherapy, and radiation therapy. However, recent advances in targeted delivery system...
Establishment, authenticity, and characterization of cervical cancer cell lines [0.03%]
宫颈癌细胞系的建立、鉴定及特征分析
Ma de Lourdes Zuñiga Martinez,Carlos Miguel López Mendoza,Jared Tenorio Salazar et al.
Ma de Lourdes Zuñiga Martinez et al.
Cell lines have been considered excellent research models in many areas of biomedicine and, specifically, in the study of carcinogenesis. However, they cease to be effective models if their behavior changes. Although studies on the cross-co...