Silencing Glypican-1 enhances the antitumor effects of Pictilisib via downregulating PI3K/Akt/ERK signaling in chemo-resistant esophageal adenocarcinoma [0.03%]
沉默Glypican-1通过下调PI3K/Akt/ERK信号通路增强Pictilisib在化疗耐药食管腺癌中的抗肿瘤作用
Akshay Pratap,Andrea Qualman,Hedlund Garrett et al.
Akshay Pratap et al.
Poorly differentiated esophageal adenocarcinoma (PDEAC) has a dismal prognosis. Glypican-1(GPC-1) is known to be upregulated in several cancer types in contrast to healthy tissues, rendering it as a biomarker. Nevertheless, the potential th...
The identification of key genes and pathways in glioblastoma by bioinformatics analysis [0.03%]
生物信息学分析识别胶质母细胞瘤的关键基因和途径
Zahra Farsi,Najaf Allahyari Fard
Zahra Farsi
GBM is the most common and aggressive type of brain tumor. It is classified as a grade IV tumor by the WHO, the highest grade. Prognosis is generally poor, with most patients surviving only about a year. Only 5% of patients survive longer t...
The developmental gene Chordin is amplified and expressed in human cancers [0.03%]
人类癌症中发育基因Chordin的扩增和表达
Eric Sosa,Edward M De Robertis
Eric Sosa
Chordin (CHRD) is a secreted protein important in early development, yet a role for CHRD in human disease has not been identified. In this study we investigated CHRD in cancer and normal adult tissues using the wealth of genome-wide data av...
Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer [0.03%]
巴西前列腺癌患者血浆病毒组的元基因组学见解
Dalila Luciola Zanette,Karoline Brito Caetano Andrade Coelho,Eneas de Carvalho et al.
Dalila Luciola Zanette et al.
Growing evidence suggests that metavirome changes could be associated increased risk for malignant cell transformation. Considering Viruses have been proposed as factors for prostate cancer induction. The objective of this study was to exam...
Therapeutic potential of targeting mirnas to prostate cancer tumors: using psma as an active target [0.03%]
靶向PSMA作为活性位点的mirna在前列腺癌治疗中的潜力研究
Amir Yarahmadi,Romoye Sohan,Brenna McAllister et al.
Amir Yarahmadi et al.
Prostate cancer (PC) is a commonly diagnosed malignancy in men and is associated with high mortality rates. Current treatments for PC include surgery, chemotherapy, and radiation therapy. However, recent advances in targeted delivery system...
Establishment, authenticity, and characterization of cervical cancer cell lines [0.03%]
宫颈癌细胞系的建立、鉴定及特征分析
Ma de Lourdes Zuñiga Martinez,Carlos Miguel López Mendoza,Jared Tenorio Salazar et al.
Ma de Lourdes Zuñiga Martinez et al.
Cell lines have been considered excellent research models in many areas of biomedicine and, specifically, in the study of carcinogenesis. However, they cease to be effective models if their behavior changes. Although studies on the cross-co...
François Ghiringhelli
François Ghiringhelli
Resistance to chemoimmunotherapy is a major issue for cancer care. We recently unravelled the role of mitogen-activated protein kinase (MAPK) to limit the antitumor efficacy of such combination. Inhibitor of MAPK pathway using mitogen-activ...
Gaurav Mendiratta,Michael K Jones,Edward C Stites
Gaurav Mendiratta
Genome sequenced samples from cancer patients helped identify roles of different mutation types and enabled targeted therapy development. However, critical questions like what are the gene mutation rates among the patients? or what genes ar...
Marjorie Lapouge,Sylvain Meloche
Marjorie Lapouge
Identification of dominant, actionable oncogenic signaling pathways is key to guide the development of new targeted treatments for advanced-stage hepatocellular carcinoma (HCC). We have recently unveiled a novel YES-YAP/TAZ signaling axis i...
CircZNF609 as a prototype to elucidate the biological function of circRNA-mRNA interactions [0.03%]
环状RNA-circZNF609通过结合靶mRNA来阐明环状RNA的生物学功能原型作用研究
Manuel Beltran,Francesca Rossi,Irene Bozzoni
Manuel Beltran
Circular RNAs (circRNAs) are expressed and are regulated in many biological processes but little is known about their ability to directly control mRNA homeostasis. We show that circRNA zinc finger protein 609 (circZNF609) interacts with sev...