CHK1 inhibition overcomes gemcitabine resistance in non-small cell lung cancer cell A549 [0.03%]
CHK1抑制可克服非小细胞肺癌A549细胞中吉西他滨的耐药性
Zhi-Yin Ke,Tian Fu,Xue-Chun Wang et al.
Zhi-Yin Ke et al.
The purpose of the study is mainly to investigate anti proliferation of non-small cell lung cancer A549 cells and its mechanism by inhibition of CHK1 expression combined with gemcitabine. The mRNA and protein levels of genes were analyzed b...
The immunopeptidome of colon cancer cells treated with topoisomerase inhibiting drug reveals differential as well as common endogenous protein sampling and display of MHC I-associated peptides [0.03%]
使用拓扑异构酶抑制药物处理的结肠癌细胞的免疫肽组揭示了MHC I相关肽类的不同以及共同的内源性蛋白采样和展示
Deepa Bedi,Mohammed Hassan,Alehegne Yirsaw et al.
Deepa Bedi et al.
Immunotherapy options for microsatellite stable (MSS) colorectal cancer are currently very limited. The lack of detectably unique or altered immunogens in the tumor microenvironment may be a factor. Radiation and chemotherapy may enhance im...
METTL14-mediated m6A modification upregulates HOXB13 expression to activate NF-κB and exacerbate cervical cancer progression [0.03%]
METTL14介导的m6A修饰通过上调HOXB13表达激活NF-κB并加重宫颈癌进展
Qian Li,Na Zhao,Xuejing Ding et al.
Qian Li et al.
Cervical cancer (CC) is one of the common malignant tumors in women, and the incidence rate is located in the second place of female tumors. As a major RNA N6-methyladenosine (m6A) methyltransferase, methyltransferase-like 14 (METTL14) is i...
An antibody-drug conjugate for endometrioid carcinoma based on the expression of cell adhesion molecule 1 [0.03%]
基于细胞粘附分子1表达的抗体药物偶联物治疗子宫内膜样癌研究进展
Man Hagiyama,Azusa Yoneshige,Tomoyuki Otani et al.
Man Hagiyama et al.
Cell adhesion molecule 1 (CADM1), an immunoglobulin superfamily member, is expressed in endometrial glandular cells highly during the proliferative phase but lowly during the secretory phase. Previously, a CADM1-targeting antibody-drug conj...
Shahriar Tarighi,Poonam Kumari,Alejandro Vaquero et al.
Shahriar Tarighi et al.
The nucleolar enzyme sirtuin 7 (SIRT7) promotes cancer progression in certain malignancies, likely in part by controlling ribosome biosynthesis. Recently, we discovered that SIRT7 destabilizes the cyclin dependent kinase inhibitor 2A (CDKN2...
Amino acid deprivation in cancer cells with compensatory autophagy induction increases sensitivity to autophagy inhibitors [0.03%]
氨基酸剥夺诱发癌细胞补偿性自噬增加其对自噬抑制剂的敏感性
Takahito Fukui,Manami Yabumoto,Misuzu Nishida et al.
Takahito Fukui et al.
Inhibition of autophagy is an important strategy in cancer therapy. However, prolonged inhibition of certain autophagies in established cancer cells may increase therapeutic resistance, though the underlying mechanisms of its induction and ...
Tamara C Klockner,Christopher S Campbell
Tamara C Klockner
Aneuploidy, the presence of an aberrant number of chromosomes, has been associated with tumorigenesis for over a century. More recently, advances in karyotyping techniques have revealed its high prevalence in cancer: About 90% of solid tumo...
Clemastine and hyperthermia enhance sensitization of osteosarcoma cells for apoptosis [0.03%]
Clemastine和高温可增强骨肉瘤细胞凋亡的敏化作用
Somtochukwu Obu,Suryakant Niture,Hieu Hoang et al.
Somtochukwu Obu et al.
Clemastine is an antagonist of histamine H1 receptor may provide benefits in the treatment of osteosarcoma (OS). In the current study, we used hyperthermia approach to sensitize OS cells to clemastine-mediated cell death. Osteosarcoma U-2 O...
Regulation of Med1 protein by overexpression of BAP1 in breast cancer cells [0.03%]
BAP1过表达对乳腺癌细胞中Med1蛋白的调节作用
Hyunju Kim
Hyunju Kim
Med1 binds to a nuclear receptor and regulates transcription. Elevated Med1 protein expression promotes cancer growth in hormone-dependent breast and prostate cancers. Med1 protein expression was investigated by deubiquitinating enzymes (DU...
Molecular analysis to identify novel potential biomarkers as drug targets in colorectal cancer therapy: an integrated bioinformatics analysis [0.03%]
一项综合生物信息学分析：分子分析鉴定结直肠癌治疗中的新潜在生物标志物及药物靶点
Mansour K Gatasheh,Sathan Raj Natarajan,Rajapandiyan Krishnamoorthy et al.
Mansour K Gatasheh et al.
Colorectal cancer (CRC) is a heterogeneous disease that requires new diagnostic and prognostic markers. Integrated bioinformatics approach to identify novel therapeutic targets associated with CRC. Using GEO2R identified DEGs in CRC, and Fu...