Shahriar Tarighi,Poonam Kumari,Alejandro Vaquero et al.
Shahriar Tarighi et al.
The nucleolar enzyme sirtuin 7 (SIRT7) promotes cancer progression in certain malignancies, likely in part by controlling ribosome biosynthesis. Recently, we discovered that SIRT7 destabilizes the cyclin dependent kinase inhibitor 2A (CDKN2...
Amino acid deprivation in cancer cells with compensatory autophagy induction increases sensitivity to autophagy inhibitors [0.03%]
氨基酸剥夺诱发癌细胞补偿性自噬增加其对自噬抑制剂的敏感性
Takahito Fukui,Manami Yabumoto,Misuzu Nishida et al.
Takahito Fukui et al.
Inhibition of autophagy is an important strategy in cancer therapy. However, prolonged inhibition of certain autophagies in established cancer cells may increase therapeutic resistance, though the underlying mechanisms of its induction and ...
Tamara C Klockner,Christopher S Campbell
Tamara C Klockner
Aneuploidy, the presence of an aberrant number of chromosomes, has been associated with tumorigenesis for over a century. More recently, advances in karyotyping techniques have revealed its high prevalence in cancer: About 90% of solid tumo...
Clemastine and hyperthermia enhance sensitization of osteosarcoma cells for apoptosis [0.03%]
Clemastine和高温可增强骨肉瘤细胞凋亡的敏化作用
Somtochukwu Obu,Suryakant Niture,Hieu Hoang et al.
Somtochukwu Obu et al.
Clemastine is an antagonist of histamine H1 receptor may provide benefits in the treatment of osteosarcoma (OS). In the current study, we used hyperthermia approach to sensitize OS cells to clemastine-mediated cell death. Osteosarcoma U-2 O...
Regulation of Med1 protein by overexpression of BAP1 in breast cancer cells [0.03%]
BAP1过表达对乳腺癌细胞中Med1蛋白的调节作用
Hyunju Kim
Hyunju Kim
Med1 binds to a nuclear receptor and regulates transcription. Elevated Med1 protein expression promotes cancer growth in hormone-dependent breast and prostate cancers. Med1 protein expression was investigated by deubiquitinating enzymes (DU...
Molecular analysis to identify novel potential biomarkers as drug targets in colorectal cancer therapy: an integrated bioinformatics analysis [0.03%]
一项综合生物信息学分析：分子分析鉴定结直肠癌治疗中的新潜在生物标志物及药物靶点
Mansour K Gatasheh,Sathan Raj Natarajan,Rajapandiyan Krishnamoorthy et al.
Mansour K Gatasheh et al.
Colorectal cancer (CRC) is a heterogeneous disease that requires new diagnostic and prognostic markers. Integrated bioinformatics approach to identify novel therapeutic targets associated with CRC. Using GEO2R identified DEGs in CRC, and Fu...
Mass spectrometry-based proteomic analysis to characterize cisplatin induced early signaling events in head and neck squamous cell carcinoma [0.03%]
基于质谱的蛋白质组学分析用于表征头颈部鳞状细胞癌中顺铂诱导的早期信号事件
Ankit P Jain,Vivek Ghose,Srijon Munshi et al.
Ankit P Jain et al.
Cisplatin is the commonly used chemotherapeutic drug in treatment of various cancers. However, development of resistance towards cisplatin results in tumor recurrence. Here, we aim to understand the mechanisms of action of cisplatin and eme...
Hypofunction of macrophage chemotaxis contributes to defective efficacy of herceptin in HER2-positive breast cancer patients [0.03%]
巨噬细胞趋化功能低下的确证对HER2阳性乳腺癌患者赫赛汀疗效的影响
Yu Song,Qiao-Chen Geng,Wen-Jing An et al.
Yu Song et al.
Breast cancer was considered as a kind of prone breast tumors with the complicated pathological mechanisms and diverse clinical classifications. In the clinical treatments of HER2-positive tumor patients, HER2 monoclonal antibodies, such as...
Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells [0.03%]
芒果核提取物通过细胞周期阻滞和诱导凋亡抑制肺肿瘤细胞的活力和增殖
Hussah Abdullah Alshwyeh,Warqaa Muhammed Shariff Al-Sheikh,Abdullah Rasedee et al.
Hussah Abdullah Alshwyeh et al.
In this study, we investigated the effects of an ethanolic extract of Mangifera indica L. kernel on the viability and proliferation of human lung cancer cells. We utilized MTT and BrdU cell proliferation assays, morphological assessments, c...
Subramanian Venkatesan,Mihaela Angelova,Jirina Bartkova et al.
Subramanian Venkatesan et al.
Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy num...