Control of S phase duration: a replication capacity model with E2F transcription at its heart [0.03%]
S期长度的调控：以E2F转录为核心的复制能力模型
Cosetta Bertoli,Robertus A M de Bruin
Cosetta Bertoli
DNA replication capacity, the maximal amount of DNA a cell can synthesize at any given time during S phase, is controlled by E2F-dependent transcription. Controlling replication capacity limits the replication rate and provides a robust mec...
Ketosis versus carbotoxicity - metabolism determines the outcome of cancer immunotherapy [0.03%]
生酮饮食与低碳饮食的抗肿瘤免疫效应差异：代谢决定癌症免疫治疗的效果
Aitziber Buqué,Lorenzo Galluzzi,Guido Kroemer
Aitziber Buqué
Carbohydrate-rich diets have been consistently associated with detrimental effects for human health, including diabetes and obesity. Moreover, high glucose levels appear to mediate immunosuppressive effects in preclinical tumor models. Rece...
Shu-Yong Lin,Sheng-Cai Lin
Shu-Yong Lin
Remodeling of lipid metabolism has been implicated in cancers; however, it remains obscure how the lipid metabolic pathways are altered by oncogenic signaling to affect tumor development. We have recently shown that proto-oncogene tyrosine-...
Elixabet Lopez-Lopez,William E Evans
Elixabet Lopez-Lopez
Measuring the amount of methotrexate polyglutamates (MTXPG) in leukemia cells after high-dose methotrexate (HDMTX) revealed that molecular subtype and lineage of acute lymphoblastic leukemia (ALL), the ratio of expression of folate influx a...
eMIONs: novel genetically engineered nanocages for magnetic hyperthermia cancer therapy [0.03%]
用于磁性热疗的新型基因工程纳米笼用于癌症治疗
Zhao Lei,Yang Zhang,Gang Liu
Zhao Lei
The clinical introduction of magnetic hyperthermia therapy (MHT) has been hindered by current available agents with poor magnetic-to-thermal conversion efficiency and biocompatibility. It is believed that the genetically engineered magnetic...
BOK-MCL1 transmembrane interactions: a challenging target for cancer therapy [0.03%]
BOK-MCL1跨膜相互作用：癌症治疗的潜在靶点
Mónica Sancho,Mar Orzáez
Mónica Sancho
Myeloid cell leukemia 1 (MCL1) gene amplification occurs in a wide range of human cancers and protein overexpression associates with malignant cell growth and evasion of apoptosis. We recently reported that disrupting the interaction betwee...
Ting Tao,Hui Shi,Adam D Durbin et al.
Ting Tao et al.
We recently identified activated protein kinase B (PKB/AKT) as a tumorigenic driver in childhood ganglioneuroma. Inhibition of the mechanistic target of rapamycin (mTOR), a serine/threonine kinase downstream of AKT, effectively reduced the ...
Roles of SDE2 and TIMELESS at active and stalled DNA replication forks [0.03%]
SDE2和TIMELESS在活跃及停滞DNA复制叉上的作用机制研究
Natalie Lo,Julie Rageul,Hyungjin Kim
Natalie Lo
The fork protection complex (FPC), comprising the TIMELESS (TIM)-TIPIN heterodimer, acts as a scaffold of the replisome to support seamless DNA replication. We recently showed that SDE2, a PCNA-associated DNA replication stress regulator, m...
Enhancing endocrine therapy activity via fasting cycles: biological rationale and clinical feasibility [0.03%]
基于周期性禁食的内分泌治疗增效策略：生物学原理和临床可行性探讨
Irene Caffa,Alessio Nencioni
Irene Caffa
We found that periodic fasting increases the anti-cancer activity of endocrine agents used to treat hormone receptor-positive breast cancer and delays acquired resistance to them by reducing blood leptin, insulin and insulin-like growth fac...
P53 orchestrates a complex symphony of cellular processes during oncosuppression [0.03%]
p53通过调控复杂的细胞过程发挥抑癌作用
Liz J Valente,Laura D Attardi
Liz J Valente
We recently showed that the p53 tumor suppressor simultaneously governs numerous cellular processes in one model of transformation suppression. These findings suggest that p53-mediated tumor suppression relies on coordinated modulation of d...