Julia I-Ju Leu,Maureen E Murphy,Donna L George
Julia I-Ju Leu
The tumor protein P53 (TP53, or p53) has complex and at times seemingly contradictory roles in the regulation of metabolism and ferroptosis sensitivity. We find that the actions of p53 influence the redox state, which can trigger changes in...
Sabine Elowe
Sabine Elowe
At the metaphase-to-anaphase transition, phosphatase activity feeds back to reverse early mitotic phosphorylation events. Our recent work indicates that the pseudokinase domain of the spindle checkpoint protein BUB1 (Budding Uninhibited by ...
Didem Ilter,Ana P Gomes
Didem Ilter
Aging is a main risk factor for cancer. Using human serum we demonstrated that tumor progression and metastases occur, at least in part, as a manifestation of global metabolic deregulation of the aged host. This shows that the role of aging...
Phosphoglycerate mutase 1 (PGAM1) overexpression promotes radio- and chemoresistance in gliomas by activating the DNA damage response [0.03%]
磷酸甘油酸互变酶1(PGAM1)过表达通过激活DNA损伤反应促进胶质瘤的放化疗耐药性
Tor-Christian Aase Johannessen,Joydeep Mukherjee
Tor-Christian Aase Johannessen
The glycolytic enzyme PGAM1 is overexpressed in gliomas where it efficiently facilitates the repair of DNA damage. Mechanistically, PGAM1 prevents inactivation of the ataxia-telangiectasia mutated (ATM) signaling pathway by sequestering the...
Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking [0.03%]
吸烟定义的透明细胞肾细胞癌代谢亚型
Maria F Czyzyk-Krzeska,Jarek Meller,Julio A Landero Figueroa et al.
Maria F Czyzyk-Krzeska et al.
Tobacco smoking (TS) results in reprogramming of major metabolic pathways, including glycolysis, the citric acid (TCA) cycle, oxidative phosphorylation, and metabolism of aspartate, glutamate and glutamine in clear cell renal cell carcinoma...
p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control [0.03%]
P62/SQSTM1液滴启动自噬小体生成及氧化应激调控
Eeva-Liisa Eskelinen,Shun Kageyama,Masaaki Komatsu
Eeva-Liisa Eskelinen
Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation a...
John R P Knight,Owen J Sansom
John R P Knight
~50% of colorectal cancers have an activating mutation in KRAS (encoding the KRAS proto-oncogene) and remain difficult to target in the clinic. We have recently shown that activation of KRAS protein alters the regulation of mRNA translation...
Jiadi Lv,Yuying Liu,Bo Huang
Jiadi Lv
Developing a method that can effectively define and sort cancer stem cells (CSCs) is extremely desirable. Mechanical stiffness is of paramount importance for a cell to differentiate and can reflect the differentiation state of cells. In lin...
A JAK of all trades: how global phosphoproteomics reveal the Achilles heel of MPNs [0.03%]
穿刺jak针眼：全球磷酸蛋白质组学如何揭示MPN的阿喀琉斯之踵
Tina M Schnoeder,Florian Perner,Florian H Heidel
Tina M Schnoeder
While Janus-kinase (JAK)-inhibitors effectively reduce the inflammatory phenotype of myeloproliferative neoplasms (MPN), they do not affect disease burden or presence of the mutated clone to a major extent. Here, we show how Janus-kinase 2 ...
Padma Kadiyala,Jason V Gregory,Pedro R Lowenstein et al.
Padma Kadiyala et al.
Glioblastoma is an aggressive brain tumor with poor prognosis. The brain is protected by the blood-brain barrier, which precludes transport of chemotherapeutics. We developed nanoparticles that achieve delivery of small-interfering RNA agai...