Zhenyu Cai,Zheng-Gang Liu
Zhenyu Cai
Necroptosis is a form of regulated necrotic cell death that is mediated by receptor-interacting protein 1 (RIP1) and RIP3 kinases. Diverse receptors, including death receptors, Toll-like receptors, interferon receptors, and DAI DNA receptor...
Sean G Rudd,Julie Bianchi,Aidan J Doherty
Sean G Rudd
The DNA-directed primase-polymerase PrimPol of the archaeo-eukaryotic primase superfamily represents an ancient solution to the many problems faced during genome duplication. This versatile enzyme is capable of initiating de novo DNA/RNA sy...
Approaches to uncovering cancer diagnostic and prognostic molecular signatures [0.03%]
揭示癌症诊断和预后分子特征的方法
Shengjun Hong,Yi Huang,Yaqiang Cao et al.
Shengjun Hong et al.
The recent rapid development of high-throughput technology enables the study of molecular signatures for cancer diagnosis and prognosis at multiple levels, from genomic and epigenomic to transcriptomic. These unbiased large-scale scans prov...
Homologous recombination maintenance of genome integrity during DNA damage tolerance [0.03%]
同源重组在DNA损伤耐受过程中的作用及其对基因组稳定性的维护
Félix Prado
Félix Prado
The DNA strand exchange protein Rad51 provides a safe mechanism for the repair of DNA breaks using the information of a homologous DNA template. Homologous recombination (HR) also plays a key role in the response to DNA damage that impairs ...
Oncogenic and oncosuppressive signal transduction at mitochondria-associated endoplasmic reticulum membranes [0.03%]
与内质网膜相关线粒体的致癌和抑癌信号转导
Saverio Marchi,Carlotta Giorgi,Monika Oparka et al.
Saverio Marchi et al.
The different mechanisms employed by proto-oncogenes and tumor suppressors to regulate cell death pathways are strictly linked to their localization. In addition to the canonical control of apoptosis at a transcriptional/nuclear level, intr...
Dong Wook Choi,Cheol Yong Choi
Dong Wook Choi
Homeodomain-interacting protein kinase 2 (HIPK2) is a serine/threonine protein kinase that participates in the regulation of diverse cellular activities as a transcriptional cofactor and signal transducer. HIPK2 senses various signaling cue...
N D Marchenko,U M Moll
N D Marchenko
The p53 tumor suppressor network plays a fundamental surveillance role in both homeostatic and adaptive cell biology. p53 is one of the most important barriers against malignant derailment of normal cells, orchestrating growth arrest, senes...
Epigenetic control of gene expression in leukemogenesis: Cooperation between wild type MLL and MLL fusion proteins [0.03%]
MLL融合蛋白与野生型MLL蛋白在白血病发病机制中的表观遗传协同作用调控基因表达的功能研究
Erica Ballabio,Thomas A Milne
Erica Ballabio
Although there has been great progress in the treatment of human cancers, especially leukemias, many remain resistant to treatment. A major current focus is the development of so-called epigenetic drugs. Epigenetic states are stable enough ...
Predictive value of epigenetic alterations in head and neck squamous cell carcinoma [0.03%]
头颈部鳞状细胞癌表观遗传改变的预测价值
Jennifer Koffler,Sarika Sharma,Jochen Hess
Jennifer Koffler
Head and neck cancer collectively describes malignant tumors originating from the mucosal surface of the upper aerodigestive tract. These tumors pose a great threat to public health because of their high incidence and mortality. Traditional...
Stephane Schmucker,Izabela Sumara
Stephane Schmucker
Polo-like kinase 1 (PLK1) is a key regulator of eukaryotic cell division. During mitosis, dynamic regulation of PLK1 is crucial for its roles in centrosome maturation, spindle assembly, microtubule-kinetochore attachment, and cytokinesis. S...