N D Marchenko,U M Moll
N D Marchenko
The p53 tumor suppressor network plays a fundamental surveillance role in both homeostatic and adaptive cell biology. p53 is one of the most important barriers against malignant derailment of normal cells, orchestrating growth arrest, senes...
Epigenetic control of gene expression in leukemogenesis: Cooperation between wild type MLL and MLL fusion proteins [0.03%]
MLL融合蛋白与野生型MLL蛋白在白血病发病机制中的表观遗传协同作用调控基因表达的功能研究
Erica Ballabio,Thomas A Milne
Erica Ballabio
Although there has been great progress in the treatment of human cancers, especially leukemias, many remain resistant to treatment. A major current focus is the development of so-called epigenetic drugs. Epigenetic states are stable enough ...
Predictive value of epigenetic alterations in head and neck squamous cell carcinoma [0.03%]
头颈部鳞状细胞癌表观遗传改变的预测价值
Jennifer Koffler,Sarika Sharma,Jochen Hess
Jennifer Koffler
Head and neck cancer collectively describes malignant tumors originating from the mucosal surface of the upper aerodigestive tract. These tumors pose a great threat to public health because of their high incidence and mortality. Traditional...
Stephane Schmucker,Izabela Sumara
Stephane Schmucker
Polo-like kinase 1 (PLK1) is a key regulator of eukaryotic cell division. During mitosis, dynamic regulation of PLK1 is crucial for its roles in centrosome maturation, spindle assembly, microtubule-kinetochore attachment, and cytokinesis. S...
Andreas Linkermann,Ulrich Kunzendorf,Stefan Krautwald
Andreas Linkermann
When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer [0.03%]
当防御变成攻击：与HPV相关癌症体细胞突变有关的抗病毒胞苷脱氨酶
Stephen Henderson,Ankur Chakravarthy,Tim Fenton
Stephen Henderson
The APOBEC3 cytidine deaminases play an important role in innate immunity but have also emerged as mediators of somatic mutations in human cancer. We recently reported a high incidence of APOBEC-mediated driver mutations in human papillomav...
Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1 [0.03%]
急性胰腺炎通过激活Nupr1促进Kras(G12D)诱导的胰腺上皮细胞转化及小鼠胰腺肿瘤发生
Daniel Grasso,Maria Noé Garcia,Tewfik Hamidi et al.
Daniel Grasso et al.
During the initiation stage of pancreatic adenocarcinoma induced by oncogenic Kras, pancreatic cells are exposed to both a protumoral effect and an opposing tumor suppressive process known as oncogene-induced senescence. Pancreatitis disrup...
Lance S Terada,Zhe Liu
Lance S Terada
Aggressive carcinomas tend to adopt behaviors normally restricted to lymphocytes, including anchorage-independent mobilization, response to chemokines, and modulation of local inflammatory conditions. In a recent study we identified the lym...
Gwenola Manic,Florine Obrist,Guido Kroemer et al.
Gwenola Manic et al.
Macroautophagy (herein referred to as autophagy) is a highly conserved mechanism for the lysosomal degradation of cytoplasmic components. Autophagy is critical for the maintenance of intracellular homeostasis, both in baseline conditions an...
Xiaojie Xu,Qinong Ye
Xiaojie Xu
Viral infection may play a causative role in human cancers, for example hepatitis B virus (HBV) or hepatitis C virus (HCV) in liver cancer, human papilloma virus (HPV) in cervical cancer, and Epstein-Barr virus (EBV) in nasopharyngeal carci...