Regulation of glycolysis and cancer cell proliferation by PKM2 citrullination [0.03%]
PKM2瓜氨酸化对糖酵解及肿瘤细胞增殖的调控作用
Sébastien Coassolo,Irwin Davidson
Sébastien Coassolo
Conversion of peptidyl-arginine to peptidyl citrulline, known as citrullination, is a post-translational protein modification catalyzed by the PADI (Protein Arginine Deiminase) family of enzymes. PADI1 and PADI3 catalyze citrullination of a...
Arvind Singh Mer,Mark D Minden,Benjamin Haibe-Kains et al.
Arvind Singh Mer et al.
Acute myeloid leukemia (AML) is heterogeneous with one common subtype recognized by the presence of recurrent mutation of nucleophosmin-1 (NPM1). Emerging evidence indicates that within NPM1 mutated AML there is variation in outcome which c...
Robert E Means,Samuel G Katz
Robert E Means
Regulation of cell life and death by members of the BCL-2 family of proteins occurs at the mitochondria. Large portions of the mitochondria's outer membrane are found in tight approximation with the endoplasmic reticulum (ER), known as mito...
Combining VEGF receptor inhibitors and angiotensin-(1-7) to target renal cell carcinoma [0.03%]
将VEGF受体抑制剂和血管紧张素-(1-7)结合以针对肾细胞癌
Thomas Walther,Prateek Khanna,Rupal S Bhatt
Thomas Walther
Resistance to tyrosine kinase inhibitors of the vascular endothelial growth factor receptor inevitably develops in most patients with metastatic kidney cancer. Our recent findings demonstrate that addition of angiotensin-(1-7) peptide can b...
The concerted action of oncogenic driver mutations directs global translation in intestinal epithelial cells [0.03%]
致癌驱动突变的协同作用指导肠道上皮细胞的整体翻译
Wouter Smit,Jarom Heijmans
Wouter Smit
Oncogenic transformation of colorectal cancer cells is driven by a set of mutations that cause aberrant signaling of growth factor-receptor pathways. Using organoids, we demonstrate that the most frequent driver mutations in APC, KRAS, SMAD...
A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis [0.03%]
一种新的mTORC1介导的胱氨酸感应机制调控GPX4合成并抑制铁死亡发生
Yuelong Yan,Guang Lei,Boyi Gan
Yuelong Yan
Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamyc...
Regulation of autophagy by VPS34 branched ubiquitination controls proteostasis and liver metabolism [0.03%]
VPS34泛素化调节自噬作用控制蛋白稳态和肝脏代谢
Yu-Hsuan Chen,Ruey-Hwa Chen
Yu-Hsuan Chen
Ubiquitin-proteasome system and autophagy are the two major recycling processes. Our recent work uncovers a K29/K48 branched ubiquitination on the phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3KC3, best known as VPS34). This ub...
Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A [0.03%]
有丝分裂纺锤体组装检验点和KIF18A的癌症治疗靶向作用机制与染色体非整倍体的相关性研究
Yael Cohen-Sharir,Uri Ben-David
Yael Cohen-Sharir
Aneuploidy, a common feature of cancer cells, results in increased sensitivity to the inhibition of the spindle assembly checkpoint (SAC) and the mitotic motor protein Kinesin Family Member 18A (KIF18A). We discuss the importance of drugs t...
Christina Cooley,Le Su
Christina Cooley
The function of histone deacetylase 2 (HDAC2) in transcriptional regulation and its role in oncogenesis have been well established. Here we discuss a transcription-independent HDAC2 pathway controlling cancer-related protein stability via t...
The importance of transmembrane domain interactions in the viral control of apoptosis [0.03%]
跨膜结构域相互作用在病毒控制凋亡中的重要性
Gerard Duart,Ismael Mingarro,Luis Martinez-Gil
Gerard Duart
Viral control of apoptosis occurs through the expression of viral encoded anti-apoptotic B-cell lymphoma 2 (BCL2) analogs. These proteins are thought to restrain apoptosis by interacting with cellular BCL2 family members. We identified that...