Lactylation-related genes signature panel in hepatocellular carcinoma reveals the prognostic and therapeutic optimization [0.03%]
肝细胞癌中乳酰化相关基因特征谱的预后及治疗优化价值
Ting Xiao,Xianqun Xu,Ziwu Zhao et al.
Ting Xiao et al.
Lactylation-related genes (LRGs) exert a significant influence on tumor progression and are critically involved in modulating responses to immune checkpoint inhibitors (ICIs). Leveraging a curated set of 332 LRGs derived from the literature...
SNX1 inhibits human ovarian cancer progression via regulation of the cell cycle, apoptosis and migration [0.03%]
SNX1通过调节细胞周期、凋亡和迁移抑制人类卵巢癌进展
Pin Li,Xiaoyan Yu,Kailing Wen et al.
Pin Li et al.
Sorting nexin 1 (SNX1), a member of the sorting nexin family, has been implicated in various cellular processes, yet its role in ovarian cancer (OV) remains poorly characterized. In this study, we systematically investigated the expression ...
Single-cell analysis reveals XCL1+ CD8+ T cells as a therapeutic target in hepatocellular carcinoma [0.03%]
单细胞分析揭示XCL1+CD8+T细胞可作为肝细胞癌的治疗靶点
Guowei Li,Fan Yang,Zechao Li et al.
Guowei Li et al.
XCL1 (lymphotactin), a C-chemokine primarily produced by activated CD8+ T cells, remains poorly characterized in the context of immunotherapy. Here, we conducted comprehensive analyses based on multiple scRNA-seq datasets to identify the pr...
Inactivation of Acetyl-CoA Acyltransferase 1 enhances the proliferation and motility of nasopharyngeal carcinoma cells [0.03%]
乙酰辅酶A酰基转移酶1失活通过促进增殖和迁移增强鼻咽癌细胞生长
Wanqi Wei,Limei Li,Weilin Zhao et al.
Wanqi Wei et al.
Acetyl-CoA acyltransferase 1 (ACAA1), encoding the peroxisomal 3-ketoacyl-CoA thiolase (POT1), plays a pivotal role in the fatty acid beta-oxidation pathway. Accumulating evidence has linked this enzyme to the onset and development of diver...
Loss of Schwann cell's normal rhythmic core clock gene expression and gain of rhythmic expression of oncogenic driver genes in malignant NF1-associated peripheral nerve sheath tumor [0.03%]
NF1相关恶性外周神经鞘瘤中施万细胞正常昼夜节律核心基因表达的丧失和致癌驱动基因节律表达的获得
Sandra Leisz,Antonio Pelligrino,Saskia Fritzsche et al.
Sandra Leisz et al.
Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor syndrome caused by pathogenic variants in the NF1 gene. Beside tumor formation, patients often have sleep disturbances, suggesting circadian involvement. Previous NF1 studies hav...
Cytokeratin expression in breast cancer: from mechanisms, progression, diagnosis, and prognosis to therapeutic implications [0.03%]
乳腺癌中细胞角蛋白的表达：从机制、进展、诊断和预后到治疗意义
Ensiyeh Bahadoran,Sahar Moghbelinejad,Ghazaleh Mohammadi et al.
Ensiyeh Bahadoran et al.
Background and aim: Cytokeratins (CKs) are structural proteins vital to epithelial integrity and play key roles in breast cancer progression. This review explores their expression, functions, and therapeutic potential. ...
TRIM22 promotes glioblastoma development by ubiquitinating Bcl-2 [0.03%]
TRIM22通过泛素化Bcl-2促进胶质母细胞瘤的发生发展
Jiahao Zhang,Yuning Chen,Gaosong Wang et al.
Jiahao Zhang et al.
Glioblastoma (GBM) exhibits elevated TRIM22 expression correlated with tumor progression, as validated in TCGA/GEO databases. The effects of TRIM22 knockdown and overexpression on GBM proliferation were evaluated with cellular assays. TRIM2...
The Role of V-ATPase ATP6V0D1 Subunit in Chemoresistance and Ellipticine-Induced Cytoplasmic Vacuolation in Neuroblastoma Cells [0.03%]
神经母细胞瘤细胞中V-ATP酶ATP6V0D1亚基在化疗耐药及椭圆素诱导的胞浆空泡化中的作用
M Rychla,J Hrabeta,P Jencova et al.
M Rychla et al.
Drug resistance remains a major obstacle in neuroblastoma treatment. Lysosomal sequestration, facilitated by the V-ATPase proton pump, is one of the mechanisms of chemoresistance. Overexpression of the ATP6V0D1 subunit of V-ATPase, previous...
GSTP1 knockdown induces metabolic changes affecting energy production and lipid balance in pancreatic cancer cells [0.03%]
GSTP1敲除诱导出影响胰腺癌细胞能量生成和脂质平衡的代谢变化
Jenna N Duttenhefner,Katie M Reindl
Jenna N Duttenhefner
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options, underscoring the need for novel therapeutic targets. Metabolic reprogramming is a hallmark of PDAC, enabling tumor cells to sustain rapid prolif...
Increased MLH1, MGMT, and p16INK4a methylation levels in colon mucosa potentially useful as early risk marker of colon cancer [0.03%]
结肠黏膜中MLH1、MGMT和p16INK4a的甲基化水平升高可作为结肠癌早期风险标记物
Yvonne Wettergren,Peter Rolny,Helena Lindegren et al.
Yvonne Wettergren et al.
The genes MutL Homolog 1 (MLH1), O6-methylguanine-DNA methyltransferase (MGMT), and cyclin-dependent kinase inhibitor p16INK4a are commonly downregulated by hypermethylation in colorectal cancer. Long interspersed nucleotide element 1 (LINE...