Integrative multi-omics profiling identifies a lactylation-associated, metabolically active, and immunosuppressive subtype of colon adenocarcinoma [0.03%]
整合多组学分析鉴定出一种与乳酰化相关的结肠腺癌代谢活跃、免疫抑制亚型
Minghui Lin,Xiaolan Huang,Zhiyuan Xia et al.
Minghui Lin et al.
Background: Histone lactylation, a lactate-derived post-translational modification, bridges metabolic activity and gene regulation. However, its molecular mechanisms and clinical significance in colon adenocarcinoma (COAD...
Mutation detection in women diagnosed with endometrial cancer: a next-generation sequencing analysis [0.03%]
绝经后被诊断为子宫内膜癌的女性患者的突变检测：一项基于下一代测序技术的研究分析
Salar Saadi Hussain,Zahra Abdulqader Amin
Salar Saadi Hussain
Endometrial cancer (EC) is a heterogeneous gynecological malignancy characterized by diverse genetic and epigenetic alterations. This study investigated genetic mutations associated with EC among Kurdish women using next-generation sequenci...
Evolutionary perspectives on endometrial cancer: antagonistic pleiotropy [0.03%]
论子宫内膜癌的进化观点：对立多效性理论
Hiroshi Kobayashi
Hiroshi Kobayashi
The incidence of endometrial cancer is increasing worldwide, with a particularly marked rise in early-onset cases. Modern environmental and lifestyle factors, including low parity, delayed childbirth, obesity, insulin resistance, and chroni...
mRNA vaccines in oncology: personalized cancer immunization and neoantigen targeting [0.03%]
肿瘤学中的信使核糖核酸疫苗：个性化癌症免疫和新抗原靶向疗法
Mridula Parganiha,Jaishriram Rathored,Deepika Sai Painkra
Mridula Parganiha
Precision oncology is evolving with personalized mRNA neoantigen vaccines, although long-term clinical responses vary. These mRNA-based vaccines have facilitated the development of patient-specific neoantigens. Clinical success is dependent...
Exploration of the diagnostic and therapeutic potential of the nucleocytoplasmic shuttling protein TMUB1 by inducing G0/G1 cell cycle arrest in ovarian cancer [0.03%]
TMUB1蛋白通过诱导卵巢癌细胞G0/G1期阻滞的诊断及治疗潜能研究
Jiahong Jiang,Jie Li,Shuai Tang et al.
Jiahong Jiang et al.
Background: Ovarian cancer is one of the leading causes of gynaecologic malignancies worldwide. This study aimed to explore the diagnostic and therapeutic potential of TMUB1 in ovarian cancer. ...
The LNK adaptor protein: a dual regulator of proliferation and migration in solid tumors [0.03%]
LNK适配蛋白：实体肿瘤增殖和迁移的双重调控因子
Jessica C Mantilla-Ollarves,Laura Velazquez,Leticia Rocha-Zavaleta
Jessica C Mantilla-Ollarves
Cancer is a significant public health problem. Alterations in critical cellular responses, such as proliferation, survival, and migration, are hallmarks of cancer. Deregulation of the JAK/STAT, MAPK, and PI3K/AKT signaling pathways has been...
Lactylation-related genes signature panel in hepatocellular carcinoma reveals the prognostic and therapeutic optimization [0.03%]
肝细胞癌中乳酰化相关基因特征谱的预后及治疗优化价值
Ting Xiao,Xianqun Xu,Ziwu Zhao et al.
Ting Xiao et al.
Lactylation-related genes (LRGs) exert a significant influence on tumor progression and are critically involved in modulating responses to immune checkpoint inhibitors (ICIs). Leveraging a curated set of 332 LRGs derived from the literature...
SNX1 inhibits human ovarian cancer progression via regulation of the cell cycle, apoptosis and migration [0.03%]
SNX1通过调节细胞周期、凋亡和迁移抑制人类卵巢癌进展
Pin Li,Xiaoyan Yu,Kailing Wen et al.
Pin Li et al.
Sorting nexin 1 (SNX1), a member of the sorting nexin family, has been implicated in various cellular processes, yet its role in ovarian cancer (OV) remains poorly characterized. In this study, we systematically investigated the expression ...
Single-cell analysis reveals XCL1+ CD8+ T cells as a therapeutic target in hepatocellular carcinoma [0.03%]
单细胞分析揭示XCL1+CD8+T细胞可作为肝细胞癌的治疗靶点
Guowei Li,Fan Yang,Zechao Li et al.
Guowei Li et al.
XCL1 (lymphotactin), a C-chemokine primarily produced by activated CD8+ T cells, remains poorly characterized in the context of immunotherapy. Here, we conducted comprehensive analyses based on multiple scRNA-seq datasets to identify the pr...
Inactivation of Acetyl-CoA Acyltransferase 1 enhances the proliferation and motility of nasopharyngeal carcinoma cells [0.03%]
乙酰辅酶A酰基转移酶1失活通过促进增殖和迁移增强鼻咽癌细胞生长
Wanqi Wei,Limei Li,Weilin Zhao et al.
Wanqi Wei et al.
Acetyl-CoA acyltransferase 1 (ACAA1), encoding the peroxisomal 3-ketoacyl-CoA thiolase (POT1), plays a pivotal role in the fatty acid beta-oxidation pathway. Accumulating evidence has linked this enzyme to the onset and development of diver...