Calpain inhibition as a possible new therapeutic target in multiple sclerosis [0.03%]
钙蛋白酶抑制作为多发性硬化症的新治疗靶点的可能性
Amena W Smith,Swapan K Ray,Arabinda Das et al.
Amena W Smith et al.
Multiple sclerosis (MS), the most common chronic autoimmune inflammatory disease of the central nervous system (CNS), is characterized by demyelination and neurodegeneration. In particular, neurodegeneration is a major factor in disease pro...
Ticagrelor is more effective than clopidogrel in carrier of nonfunctional CYP2C19 allele who has diabetes and acute coronary syndrome - case report and literature review [0.03%]
糖尿病急性冠脉综合征患者中非功能性CYP2C19等位基因携带者替格瑞洛疗效优于氯吡格雷-病例报道及文献复习
Rahel Tekeste,Gregorio Garza,Song Han et al.
Rahel Tekeste et al.
Clopidogrel is a purinergic receptor P2Y12 (P2RY12)-blocking pro-drug used to inhibit platelet aggregation in patients at risk for major adverse cardiac events (MACE), such as coronary artery disease and stroke. Despite clopidogrel therapy,...
Genotypic and phenotypic variability of 22q11.2 microdeletions - an institutional experience [0.03%]
22q11.2微缺失的基因型和表型变异-一家机构的经验
Gabrielle C Manno,Gabrielle S Segal,Alexander Yu et al.
Gabrielle C Manno et al.
Patients with chromosome 22q11.2 deletion syndromes classically present with variable cardiac defects, parathyroid and thyroid gland hypoplasia, immunodeficiency and velopharyngeal insufficiency, developmental delay, intellectual disability...
Sreemita Majumdar,Song-Tao Liu
Sreemita Majumdar
Stem cells including cancer stem cells (CSC) divide symmetrically or asymmetrically. Usually symmetric cell division makes two daughter cells of the same fate, either as stem cells or more differentiated progenies; while asymmetric cell div...
Expedited isolation of natural product peptidyl-tRNA hydrolase inhibitors from a Pth1 affinity column [0.03%]
利用Pth1亲和柱快速筛选天然产物肽基-tRNA水解酶抑制剂
Harkirat S Sethi,Jessica L Osier,Geordan L Burks et al.
Harkirat S Sethi et al.
New antibiotics and new antibiotic targets are needed to counter the development of bacterial drug resistance that threatens to return the human population to the pre-antibiotic era. Bacterial peptidyl-tRNA hydrolase (Pth1) is a promising n...
The mitotic checkpoint complex (MCC): looking back and forth after 15 years [0.03%]
细胞有丝分裂检查点复合体(MCC)研究：过去与未来展望
Song-Tao Liu,Hang Zhang
Song-Tao Liu
The mitotic checkpoint is a specialized signal transduction pathway that contributes to the fidelity of chromosome segregation. The signaling of the checkpoint originates from defective kinetochore-microtubule interactions and leads to form...
Amyloid misfolding, aggregation, and the early onset of protein deposition diseases: insights from AFM experiments and computational analyses [0.03%]
淀粉样蛋白错误折叠、聚集及蛋白质沉积病早期发生的机理：来自AFM实验和计算分析的启示
Yuri L Lyubchenko
Yuri L Lyubchenko
The development of Alzheimer's disease is believed to be caused by the assembly of amyloid β proteins into aggregates and the formation of extracellular senile plaques. Similar models suggest that structural misfolding and aggregation of p...
Richard C Petersen
Richard C Petersen
Triclosan antimicrobial molecular fluctuating energies of nonbonding electron pairs for the oxygen atom by ether bond rotations are reviewed with conformational computational chemistry analyses. Subsequent understanding of triclosan alterna...
Peter X Shaw,Travis Stiles,Christopher Douglas et al.
Peter X Shaw et al.
Age-related macular degeneration (AMD) is a leading cause of vision loss affecting tens of millions of elderly worldwide. Early AMD is characterized by the appearance of soft drusen, as well as pigmentary changes in the retinal pigment epit...
Carson C Chow,Karen M Ong,Benjamin Kagan et al.
Carson C Chow et al.
The different amounts of residual partial agonist activity (PAA) of antisteroids under assorted conditions have long been useful in clinical applications but remain largely unexplained. Not only does a given antagonist often afford unequal ...