Prior AICAR induces elevated glucose uptake concomitant with greater γ3-AMPK activation and reduced membrane cholesterol in skeletal muscle from 26-month-old rats [0.03%]
先注射AICAR可提高26月大鼠骨骼肌葡萄糖吸收，同时伴随γ3-AMPK活化增加和膜胆固醇降低
Haiyan Wang,Amy Zheng,Edward B Arias et al.
Haiyan Wang et al.
Attenuated skeletal muscle glucose uptake (GU) has been observed with advancing age. It is important to elucidate the mechanisms linked to interventions that oppose this detrimental outcome. Earlier research using young rodents and (or) cul...
Age-dependent stress response DNA demethylation and gene upregulation accompany nuclear and skeletal muscle remodeling following acute resistance-type exercise in rats [0.03%]
急性抗阻运动后大鼠核和骨骼肌重塑伴随年龄依赖性的压力反应DNA去甲基化和基因上调
Erik P Rader,Brent A Baker
Erik P Rader
Efficacy of high-intensity resistance exercise becomes progressively compromised with aging. Previously, to investigate this, we developed a rodent model of high-intensity training consisting of stretch-shortening contractions (SSCs) and de...
Stephanie O M Dyke,Katie M Saulnier,Tomi Pastinen et al.
Stephanie O M Dyke et al.
In setting up a data access policy to share controlled access data from the McGill Epigenomics Mapping Centre (EMC), an International Human Epigenome Consortium (IHEC) partner project, we encountered ethical and legal challenges that are li...