It Takes Three to Tango - the length of the oligothiophene determines the nature of the long-lived excited state and the resulting photocytotoxicity of a Ru(II) photodrug [0.03%]
三管齐下——共轭长度决定寡聚噻吩钌(ii)光药物长寿命激发态的性质及其光细胞毒性
Avinash Chettri,John A Roque rd,Kilian R A Schneider et al.
Avinash Chettri et al.
TLD1433 is the first Ru(II) complex to be tested as a photodynamic therapy agent in a clinical trial. In this contribution we study TLD1433 in the context of structurally-related Ru(II)-imidozo[4,5-f][1,10]phenanthroline (ip) complexes appe...
Exciton Emission and Light induced Charge Separation in colloidal ZnO Nanocrystals [0.03%]
胶体氧化锌纳米晶中的激子发射和光诱导电荷分离
K Kocsis,M Niedermaier,T Schwab et al.
K Kocsis et al.
Adsorption of organic molecules at ZnO nanoparticle surfaces enables the transfer of energy or charge across resulting organic-inorganic interfaces and, consequently, determines the optoelectronic performance of ZnO based hybrids. We invest...
Photoswitchable affinity reagents: Computational design and efficient red-light switching [0.03%]
光控开关配体试剂：计算设计及高效红光切换
Nobuo Yasuike,Kristin M Blacklock,Huixin Lu et al.
Nobuo Yasuike et al.
Photo-controlled affinity reagents seek to provide modular spatiotemporal control of bioactivity by conferring photo-switchability of function on an affinity reagent scaffold. Here we used Rosetta-based computational methods to screen for s...
Nonadiabatic Dynamics Simulation Predict Intersystem Crossing in Nitroaromatic Molecules on a Picosecond Time Scale [0.03%]
非绝热动力学模拟预测硝基芳烃分子皮秒时间尺度的系间窜跃过程
J Patrick Zobel,Leticia González
J Patrick Zobel
Previous time-resolved spectroscopic experiments and static quantum-chemical calculations attributed nitronaphthalene derivatives one of the fastest time scales for intersystem crossing within organic molecules, reaching the 100 fs mark. No...
Towards a Scalable Synthesis of 2-Oxabicyclo[2.2.0]hex-5-en-3-one Using Flow Photochemistry [0.03%]
一种用于合成2-氧杂双环[2.2.0]己-5-烯-3-酮的流动光化学法
Jason D Williams,Yuma Otake,Guilhem Coussanes et al.
Jason D Williams et al.
Cyclobutene lactones hold great potential as synthetic building blocks, yet their preparation by photochemical rearrangement in batch can often be a bottleneck in synthetic studies. We report the use of flow photochemistry as a tool to enab...
One-Pot Synthesis of Diverse γ-Lactam Scaffolds Facilitated by a Nebulizer-Based Continuous Flow Photoreactor [0.03%]
基于喷雾器的连续流动光反应器促进的一锅法合成多样化的γ-内酰胺骨架
Georgios I Ioannou,Tamsyn Montagnon,Dimitris Kalaitzakis et al.
Georgios I Ioannou et al.
The use of a modified prototype continuous flow reactor (CFR) as a pivotal part of a number of versatile singlet oxygen-mediated reaction sequences is presented herein. These sequences target rapid access to structural complexity and divers...
Understanding Two Different Structures in the Dark Stable State of the Oxygen-Evolving Complex of Photosystem II: Applicability of the Jahn-Teller Deformation Formula [0.03%]
了解光系统II中OEC暗稳态的两种不同结构：JT变形公式的影响及适用性
Mitsuo Shoji,Hiroshi Isobe,Ayako Tanaka et al.
Mitsuo Shoji et al.
Tanaka et al. (J. Am. Chem. Soc., 2017, 139, 1718) recently reported the three-dimensional (3D) structure of the oxygen evolving complex (OEC) of photosystem II (PSII) by X-ray diffraction (XRD) using extremely low X-ray doses of 0.03 and 0...
Spin-Forbidden Excitation: A New Approach for Triggering Photopharmacological Processes with Low-Intensity NIR Light [0.03%]
自旋 forbidden 光激发：一种利用低强度近红外光触发光药学过程的新方法
Elham Kianfar,Dogukan Hazar Apaydin,Günther Knör
Elham Kianfar
Exposure to low-intensity radiation in the near-infrared (NIR) spectral region matching the optically transparent "phototherapeutic window" of biological tissues can be applied to directly populate spin-restricted excited states of light-re...
An Acid-Responsive Single Trichromatic Luminescent Dye That Provides Pure White-Light Emission [0.03%]
一种对酸响应的单组分三色发光染料可实现纯白光发射
Keigo Imamura,Yoshifumi Ueno,Seiji Akimoto et al.
Keigo Imamura et al.
A novel acid-responsive single trichromatic luminescent dye capable of emitting pure white light (WL) is reported. A newly designed p-phenylene-bridged bipyrrole bearing N-alkylimino groups (1 a) specifically provides WL emission upon mixin...
Saposin B Binds the Lipofuscin Bisretinoid A2E and Prevents its Enzymatic and Photooxidation [0.03%]
蛙皮素B结合脂褐质双视黄醇A2E并防止其酶解和光氧化
Jay Tinklepaugh,Britannia M Smith,Yan Nie et al.
Jay Tinklepaugh et al.
Vitamin A based bisretinoid accumulation is a major focus in the study of macular degeneration. Whether specific endogenous lysosomal proteins can bind A2E, a pronounced bisretinoid in lipofuscin granules in retinal pigment epithelial cells...