Computational Study on the Photo-Induced Antibiotic Activity of an Azoquinolone with Promising Applications in Photopharmacology [0.03%]
一种光控药物的计算研究：基于偶氮喹诺酮类抗生素的光电药理学应用研究
Pedro J Castro,Orlando D Mendinueta,Mary H Mays et al.
Pedro J Castro et al.
Azocompounds are among the most important group of molecular photoswitches due to their multiple applications in various scientific areas. We studied the thermal and photochemical reactions of an azocompound with photo-induced antibiotic pr...
Genetically Encoded Lysine Analogues with Differential Light Sensitivity for Activation of Protein Function [0.03%]
具有不同光线敏感性的遗传编码赖氨酸类似物用于激活蛋白质功能
Joshua S Wesalo,Qingyang Liu,Ji Luo et al.
Joshua S Wesalo et al.
Genetically encoded unnatural amino acids are versatile tools for controlling protein function, but options for regulating multiple proteins in a single experiment are limited. Here, we report the genetic encoding of two new photocaged lysi...
Conghe Tian,Kevin Burgess
Conghe Tian
Creation of a flavylium polymethine dye set enabled selection of two fluorophores that match common lasers for exciting in the near-IR II region. Using these, researchers cast a broad net to catch any wavelength emission in the near-IR II r...
A BODIPY-Based Far-Red-Absorbing Fluorescent Probe for Hypochlorous Acid Imaging [0.03%]
用于次氯酸成像的远红吸收型荧光探针
Zhaoxiong Wan,Shupei Yu,Qi Wang et al.
Zhaoxiong Wan et al.
Hypochlorous acid (HClO) is produced by white blood cells to defend against injury and bacteria. However, as one of the reactive oxygen species, high intracellular HClO concentration could lead to chronic diseases that affect the cardiovasc...
Photochemical control of drug efficacy - a comparison of uncaging and photoswitching ifenprodil on NMDA receptors [0.03%]
光化学控制药物的效力-光开关和光脱笼伊凡 prodil 对NMDA 受体影响的比较
Ek Raj Thapaliya,Laetitia Mony,Roberto Sanchez et al.
Ek Raj Thapaliya et al.
Ifenprodil is an important negative allosteric modulator of the N-methyl-D-aspartate (NMDA) receptors. We have synthesized caged and photoswitchable derivatives of this small molecule drug. Caged ifenprodil was biologically inert before pho...
Xinglei Liu,Karthik Sambath,Lauren Hutnik et al.
Xinglei Liu et al.
Acid-sensing ion channels (ASICs), present in both central and peripheral neurons, respond to changes in extracellular protons. They play important roles in many symptoms and diseases, such as pain, ischemic stroke and neurodegenerative dis...
The Issue of Tissue: Approaches and Challenges to the Light Control of Drug Activity: A Mini-Review [0.03%]
组织问题：光控制药物活性的方法和挑战：迷你综述
Mayank Sharma,Simon H Friedman
Mayank Sharma
Photoactivatable Circular Caged Oligonucleotides for Transcriptome In Vivo Analysis (TIVA) [0.03%]
可光活化的环形核酸酶防护寡核苷酸用于转录组原位分析(TIVA)
Linlin Yang,Dora von Trentini,HyunBum Kim et al.
Linlin Yang et al.
Light activation is an effective way to impart spatiotemporal control over oligonucleotide probes that are widely applied for gene expression regulation and target function investigation. Among the major oligonucleotide caging strategies, c...
LED-NMR Monitoring of an Enantioselective Catalytic [2+2] Photocycloaddition [0.03%]
手性催化[2+2]光环加成的LED-NMR监测方法研究
Kazimer L Skubi,Wesley B Swords,Heike Hofstetter et al.
Kazimer L Skubi et al.
We report that an NMR spectrometer equipped with a high-power LED light source can be used to study a fast enantioselective photocatalytic [2+2] cycloaddition. While traditional ex situ applications of NMR provide considerable information o...
Photophysical Properties of Indocyanine Green in the Shortwave Infrared Region [0.03%]
短波红外区吲哚青绿的光物理性质研究
Emily D Cosco,Irene Lim,Ellen M Sletten
Emily D Cosco
With the growing development of new contrast agents for optical imaging using near-infrared and shortwave infrared (SWIR) wavelengths, it is essential to have consistent bench-marks for emitters in these regions. Indocyanine green (ICG), a ...