Yang Shen,B U Sebastian Schmidt,Hans Kubitschke et al.
Yang Shen et al.
Background: Cellular heterogeneity in tumor cells is a well-established phenomenon. Genetic and phenotypic cell-to-cell variability have been observed in numerous studies both within the same type of cancer cells and acro...
Dongya Jia,Mohit Kumar Jolly,Satyendra C Tripathi et al.
Dongya Jia et al.
Background: The Epithelial-Mesenchymal Transition (EMT) endows epithelial-looking cells with enhanced migratory ability during embryonic development and tissue repair. EMT can also be co-opted by cancer cells to acquire m...
A network modeling approach to elucidate drug resistance mechanisms and predict combinatorial drug treatments in breast cancer [0.03%]
一种网络建模方法阐释乳腺癌的药物耐受机制及预测其联合用药治疗方法
Jorge Gómez Tejeda Zañudo,Maurizio Scaltriti,Réka Albert
Jorge Gómez Tejeda Zañudo
Background: Mechanistic models of within-cell signal transduction networks can explain how these networks integrate internal and external inputs to give rise to the appropriate cellular response. These models can be fruit...
Clare Yu,James Kameron Mitchell
Clare Yu
Background: Why does a tumor start where it does within an organ? Location is traditionally viewed as a random event, yet the statistics of the location of tumors argues against this being a random occurrence. There are n...
Amy Wu,David Liao,Vlamimir Kirilin et al.
Amy Wu et al.
Background: The physics of cancer dormancy, the time between initial cancer treatment and re-emergence after a protracted period, is a puzzle. Cancer cells interact with host cells via complex, non-linear population dynam...
Krastan B Blagoev,David T Ting,Herbert Levine et al.
Krastan B Blagoev et al.
Amani A Alobaidi,Bo Sun
Amani A Alobaidi
Background: Multicellular pattern formation plays an important role in developmental biology, cancer metastasis and wound healing. While many physical factors have been shown to regulate these multicellular processes, the...