Bi-functional nanoparticle-stabilized hydrogel colloidosomes as both extracellular matrix and bioactive factor delivery vehicle [0.03%]
一种双功能纳米粒子稳定水凝胶胶体微囊作为递送细胞外基质和生物活性因子的载体
Rui Tang,Kentaro Umemori,Jacob Rabin et al.
Rui Tang et al.
Maintaining both cell-cell and cell-extracellular matrix (ECM) interactions is often a critical component of three-dimensional (3D) tissue regeneration. In high-density cell condensation systems, lack of appropriate cell-ECM interactions ca...
Engineering the Architecture of Elastin-Like Polypeptides: From Unimers to Hierarchical Self-Assembly [0.03%]
工程化弹性蛋白多肽的结构：从单体到层次自组装
Soumen Saha,Samagya Banskota,Stefan Roberts et al.
Soumen Saha et al.
Well-defined tunable nanostructures formed through the hierarchical self-assembly of peptide building blocks have drawn significant attention due to their potential applications in biomedical science. Artificial protein polymers derived fro...
Collagenase-Cleavable Peptide Amphiphile Micelles as a Novel Theranostic Strategy in Atherosclerosis [0.03%]
一种用于动脉粥样硬化诊疗的新颖胶原酶响应型肽 amphiphile 纳米药物递送系统
Deborah D Chin,Christopher Poon,Noah Trac et al.
Deborah D Chin et al.
Atherosclerosis is an inflammatory disease characterized by plaques that can cause sudden myocardial infarction upon rupture. Such rupture-prone plaques have thin fibrous caps due to collagenase degradation, and a noninvasive diagnostic too...
Improving STING Agonist Delivery for Cancer Immunotherapy Using Biodegradable Mesoporous Silica Nanoparticles [0.03%]
利用可降解介孔硅纳米颗粒改善STING激动剂的递送用于癌症免疫治疗
Kyung Soo Park,Cheng Xu,Xiaoqi Sun et al.
Kyung Soo Park et al.
Stimulator of interferon genes (STING) activation by intratumoral STING agonist treatment has been recently shown to eradicate tumors in preclinical models of cancer immunotherapy, generating intense research interest and leading to multipl...
Soft and Condensed Nanoparticles and Nanoformulations for Cancer Drug Delivery and Repurpose [0.03%]
用于癌症药物递送和老药新用的软性和浓缩型纳米颗粒及纳米配方
Wen Yang,Hanitrarimalala Veroniaina,Xiaole Qi et al.
Wen Yang et al.
Drug repurpose or reposition is recently recognized as a high-performance strategy for developing therapeutic agents for cancer treatment. This approach can significantly reduce the risk of failure, shorten R&D time, and minimize cost and r...
Nanomedicine-Enabled Modulation of Tumor Hypoxic Microenvironment for Enhanced Cancer Therapy [0.03%]
纳米医学调节肿瘤低氧微环境增强癌症治疗的研究进展
Jinping Wang,Beilu Zhang,Jingyu Sun et al.
Jinping Wang et al.
Hypoxia is a common condition of solid tumors that is mainly caused by enhanced tumor proliferative activity and dysfunctional vasculature. In the treatment of hypoxic human solid tumors, many conventional therapeutic approaches (e.g., oxyg...
Overcoming the Tumor Microenvironmental Barriers of Pancreatic Ductal Adenocarcinomas for Achieving Better Treatment Outcomes [0.03%]
克服肿瘤微环境障碍以改善胰腺导管腺癌的治疗效果
Rami Alzhrani,Hashem O Alsaab,Kushal Vanamal et al.
Rami Alzhrani et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with the lowest survival rate among all solid tumors. The lethality of PDAC arises from late detection and propensity of the tumor to metastasize and develop resistance ...
Superoxide Dismutase-Loaded Nanoparticles Attenuate Myocardial Ischemia-Reperfusion Injury and Protect Against Chronic Adverse Ventricular Remodeling [0.03%]
载超氧化物歧化酶纳米颗粒缓解心肌缺血再灌注损伤及对慢性室性重构的保护作用
Peter J Altshuler,Alexis R Schiazza,Lijun Luo et al.
Peter J Altshuler et al.
Early revascularization is critical to reduce morbidity after myocardial infarction, although reperfusion incites additional oxidative injury. Superoxide dismutase (SOD) is an antioxidant that scavenges reactive oxygen species (ROS) but has...
Discovery of Small Anti-ACE2 Peptides to Inhibit SARS-CoV-2 Infectivity [0.03%]
发现小分子抗ACE2肽以抑制SARS-CoV-2感染能力
Pratik Adhikary,Sashi Kandel,Umar-Farouk Mamani et al.
Pratik Adhikary et al.
COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infects host cells by binding its viral spike protein receptor-binding domain (RBD) to the angiotensin converting enzyme 2 (ACE2) on host cells. B...
Drug Repurposing for the Treatment of COVID-19: A Knowledge Graph Approach [0.03%]
用于治疗COVID-19的药物再利用：一种知识图谱方法
Vincent K C Yan,Xiaodong Li,Xuxiao Ye et al.
Vincent K C Yan et al.
Identifying effective drug treatments for COVID-19 is essential to reduce morbidity and mortality. Although a number of existing drugs have been proposed as potential COVID-19 treatments, effective data platforms and algorithms to prioritiz...