Ava Mauser,Daniel F Quevedo,Boya Zhang et al.
Ava Mauser et al.
Protein-based drug delivery systems have gained popularity due to their biocompatibility, straightforward surface modification, and potential for intrinsic therapeutic activity. Among therapeutic proteins, enzymes are particularly attractiv...
Inhalational Delivery of β- glucan-chitosan-poly(lactic co-glycolic) acid Nanoparticles Enhance Alveolar Macrophage Rifampin Concentrations for the Treatment of Tuberculosis [0.03%]
雾化吸入β-葡聚糖-壳聚糖-聚乳酸-co-乙醇酸纳米颗粒可增强肺泡巨噬细胞中利福平的浓度以治疗结核病
Hilliard L Kutscher,Maria Tamblin,Shanta Karki et al.
Hilliard L Kutscher et al.
Despite multiple treatments for tuberculosis (TB), there are ≈10 million new cases and 1.5 million deaths annually, warranting the need for new therapeutics. Major clinical treatment issues include the length of treatment which is associat...
Biomedical application of cold plasma: navigating through plasma types and devices by antimicrobial effectiveness and tissue tolerance [0.03%]
冷等离子体的生物医学应用：通过抗微生物功效和组织耐受性导航等离子体类型和设备
Thomas P Thompson,Amanda Connelly,Sean Kelly et al.
Thomas P Thompson et al.
This study compares the biofilm efficacy and tissue compatibility of three cold atmospheric plasma devices: J-Plasma (Apyx Medical), Piezo Brush PZ3 (Reylon Plasma GmbH), and Plasma Care (Terraplasma-Medical GmbH). We focused on surface tem...
Mechanical interactions impact the functions of immune cells and their application in immunoengineering [0.03%]
机械力对免疫细胞功能及其在免疫工程中应用的影响
Yu-Chang Chen,Nghi M Tran,Kyle H Vining
Yu-Chang Chen
Immune cells experience a wide range of modes and magnitudes of mechanical forces as they infiltrate tissues and physically interact with other cells. Biophysical forces influence cell phenotypes through mechanosensing of the cytoskeleton, ...
Lytic polyplex vaccines enhance antigen-specific cytotoxic T cell response through induction of local cell death [0.03%]
裂解型聚复合物疫苗可通过诱导局部细胞死亡增强特异性细胞毒性T淋巴细胞的免疫反应
David J Peeler,Albert Yen,Nicholas Luera et al.
David J Peeler et al.
Endosomolytic vaccine nanocarriers can potentiate cellular immune responses by enhancing cross-presentation. We recently developed a cationic polymer-lytic peptide conjugate (VIPER) that greatly improves endosomal escape and intracellular a...
CLINICALLY RELEVANT METALLIC NANOPARTICLES IN TUBERCULOSIS DIAGNOSIS AND THERAPY [0.03%]
用于结核病诊断和治疗的临床相关金属纳米粒子
Christianah Aarinola Akinnawo,Admire Dube
Christianah Aarinola Akinnawo
Globally we are faced with a significant burden of tuberculosis (TB), which is difficult to eradicate due to patients' non-adherance, and drug-resistant strains that are spreading at an alarming rate. Novel approaches are required to improv...
Spatiotemporal control of immune responses with nucleic acid cocktail vaccine [0.03%]
基于核酸鸡尾酒疫苗的免疫反应时空控制
Chunxi Wang,Andrew N Macintyre,Thomas H Oguin rd et al.
Chunxi Wang et al.
Nucleic acid vaccines play important roles in prevention and treatment of diseases. However, limited immunogenicity remains a major obstacle for DNA vaccine applications in the clinic. To address the issue, the present study investigates a ...
Targeting glioblastoma tumor hyaluronan to enhance therapeutic interventions that regulate metabolic cell properties [0.03%]
靶向胶质母细胞瘤肿瘤透明质酸以增强调节代谢细胞属性的治疗方法
Edward R Neves,Achal Anand,Joseph Mueller et al.
Edward R Neves et al.
Despite extensive advances in cancer research, glioblastoma (GBM) still remains a very locally invasive and thus challenging tumor to treat, with a poor median survival. Tumor cells remodel their microenvironment and utilize extracellular m...
Uncovering the Elusive Structures and Mechanisms of Prevalent Antidepressants [0.03%]
揭开广泛使用的抗抑郁药物的结构和机制之谜
Jieye Lin,Guanhong Bu,Johan Unge et al.
Jieye Lin et al.
Most treatments to alleviate major depression work by either inhibiting human monoamine transporters, vital for the reuptake of monoamine neurotransmitters, or by inhibiting monoamine oxidases, which are vital for their degradation. The ana...
Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration [0.03%]
关于生物材料在骨再生过程中调控破骨细胞分化和功能的线索研究
Kaavian Shariati,Meiwand Bedar,Kelly X Huang et al.
Kaavian Shariati et al.
Tissue regeneration involves dynamic dialogue between and among different cells and their surrounding matrices. Bone regeneration is specifically governed by reciprocity between osteoblasts and osteoclasts within the bone microenvironment. ...