COBRA Hemagglutinin and cGAMP Loaded Ace-DEX Microparticles Provide a Broadly Active and Shelf-Stable Influenza Vaccine Platform [0.03%]
一种新型的广谱抗流感疫苗平台：加载了COBRA血凝素和cGAMP的Ace-DEX微粒疫苗
Dylan A Hendy,Erik S Pena,Cole J Batty et al.
Dylan A Hendy et al.
Current FDA-approved influenza vaccines are limited by variable year to year efficacy, low immunogenicity, and poor stability outside of cold-chain storage. Polymeric microparticles can overcome many of these issues to provide an improved i...
Hailey S Sanders,Catherine G Price,Ana F de Almeida Barreto et al.
Hailey S Sanders et al.
Light-mediated healthcare has several very attractive features, including minimally invasive administration, reduced possibility of side effects, and potential for patient-specific treatment. However, the shallow penetration of light into s...
Cold Plasma Generates a Localized Inflammatory Response and Promotes Muscle Repair [0.03%]
冷等离子体产生局部炎症反应并促进肌肉修复
Carly J Smith,Amanda R Watkins,Abigail A Lucas et al.
Carly J Smith et al.
The FDA-approved Renuvion cold plasma device is currently used for dermal skin tightening procedures and subdermal tightening after liposuction. Anecdotally, patients report improved tissue healing outcomes following treatment. The most lik...
ROS-activatable Prodrug of Doxazolidine as Novel Cancer Therapy Paradigm [0.03%]
一种用于癌症治疗的新疗法：ROS激活的多沙扎利丁前药
Ryo Tamura,Chace I Carpenter,Charlotte M Thomas et al.
Ryo Tamura et al.
Overcoming severe side effects from anticancer agents without decreasing their effects on tumor growth is a major challenge. We report on a prodrug technology using agents that are spatiotemporally activated primarily in tumors while the ex...
Ava Mauser,Daniel F Quevedo,Boya Zhang et al.
Ava Mauser et al.
Protein-based drug delivery systems have gained popularity due to their biocompatibility, straightforward surface modification, and potential for intrinsic therapeutic activity. Among therapeutic proteins, enzymes are particularly attractiv...
Inhalational Delivery of β- glucan-chitosan-poly(lactic co-glycolic) acid Nanoparticles Enhance Alveolar Macrophage Rifampin Concentrations for the Treatment of Tuberculosis [0.03%]
雾化吸入β-葡聚糖-壳聚糖-聚乳酸-co-乙醇酸纳米颗粒可增强肺泡巨噬细胞中利福平的浓度以治疗结核病
Hilliard L Kutscher,Maria Tamblin,Shanta Karki et al.
Hilliard L Kutscher et al.
Despite multiple treatments for tuberculosis (TB), there are ≈10 million new cases and 1.5 million deaths annually, warranting the need for new therapeutics. Major clinical treatment issues include the length of treatment which is associat...
Biomedical application of cold plasma: navigating through plasma types and devices by antimicrobial effectiveness and tissue tolerance [0.03%]
冷等离子体的生物医学应用：通过抗微生物功效和组织耐受性导航等离子体类型和设备
Thomas P Thompson,Amanda Connelly,Sean Kelly et al.
Thomas P Thompson et al.
This study compares the biofilm efficacy and tissue compatibility of three cold atmospheric plasma devices: J-Plasma (Apyx Medical), Piezo Brush PZ3 (Reylon Plasma GmbH), and Plasma Care (Terraplasma-Medical GmbH). We focused on surface tem...
Mechanical interactions impact the functions of immune cells and their application in immunoengineering [0.03%]
机械力对免疫细胞功能及其在免疫工程中应用的影响
Yu-Chang Chen,Nghi M Tran,Kyle H Vining
Yu-Chang Chen
Immune cells experience a wide range of modes and magnitudes of mechanical forces as they infiltrate tissues and physically interact with other cells. Biophysical forces influence cell phenotypes through mechanosensing of the cytoskeleton, ...
Lytic polyplex vaccines enhance antigen-specific cytotoxic T cell response through induction of local cell death [0.03%]
裂解型聚复合物疫苗可通过诱导局部细胞死亡增强特异性细胞毒性T淋巴细胞的免疫反应
David J Peeler,Albert Yen,Nicholas Luera et al.
David J Peeler et al.
Endosomolytic vaccine nanocarriers can potentiate cellular immune responses by enhancing cross-presentation. We recently developed a cationic polymer-lytic peptide conjugate (VIPER) that greatly improves endosomal escape and intracellular a...
CLINICALLY RELEVANT METALLIC NANOPARTICLES IN TUBERCULOSIS DIAGNOSIS AND THERAPY [0.03%]
用于结核病诊断和治疗的临床相关金属纳米粒子
Christianah Aarinola Akinnawo,Admire Dube
Christianah Aarinola Akinnawo
Globally we are faced with a significant burden of tuberculosis (TB), which is difficult to eradicate due to patients' non-adherance, and drug-resistant strains that are spreading at an alarming rate. Novel approaches are required to improv...