Dendrimer-Triamcinolone Acetonide Reduces Neuroinflammation, Pathological Angiogenesis, and Neuroretinal Dysfunction in Ischemic Retinopathy [0.03%]
树状大分子曲安缩松减少缺血性视网膜病变中的神经炎症，病理血管生成和神经营养功能障碍
Hongkwan Cho,Siva P Kambhampati,Michael J Lai et al.
Hongkwan Cho et al.
Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults. Severe visual loss in DR is primarily due to proliferative diabetic retinopathy, characterized by pathologic preretinal angiogenesis driven by retinal ischem...
Engineered Multivalent Nanobodies Potently and Broadly Neutralize SARS-CoV-2 Variants [0.03%]
工程化的多价纳米抗体能够有效并且广泛地中和SARS-CoV-2变体
Jennifer M Zupancic,John S Schardt,Alec A Desai et al.
Jennifer M Zupancic et al.
The COVID-19 pandemic continues to be a severe threat to human health, especially due to current and emerging SARS-CoV-2 variants with potential to escape humoral immunity developed after vaccination or infection. The development of broadly...
Disha Panchal,Jeena Kataria,Kamiya Patel et al.
Disha Panchal et al.
The COVID-19 (coronavirus disease) global pandemic, caused by the spread of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus, currently has limited treatment options which include vaccines, anti-virals, and repurposed ...
Photothermal therapy combined with neoantigen cancer vaccination for effective immunotherapy against large established tumors and distant metastasis [0.03%]
光热疗法结合新抗原癌症疫苗有效治疗大型已建立肿瘤和远处转移病灶的免疫疗法
Jutaek Nam,Sejin Son,Kyung Soo Park et al.
Jutaek Nam et al.
Photothermal therapy (PTT) and neoantigen cancer vaccine each offers minimally invasive and highly specific cancer therapy; however, they are not effective against large established tumors due to physical and biological barriers that attenu...
The Combination of Morphology and Surface Chemistry Defines the Immunological Identity of Nanocarriers in Human Blood [0.03%]
形态和表面化学的结合定义了纳米载体在人体血液中的免疫学身份
Michael P Vincent,Nicholas B Karabin,Sean D Allen et al.
Michael P Vincent et al.
Upon exposure to blood, a corona of proteins adsorbs to nanocarrier surfaces to confer a biological identity that interfaces with the immune system. While the nanocarrier surface chemistry has long been the focus of protein corona formation...
Stephanie M Kronstadt,Alex E Pottash,Daniel Levy et al.
Stephanie M Kronstadt et al.
Sepsis is a deadly condition lacking a specific treatment despite decades of research. This has prompted the exploration of new approaches, with extracellular vesicles (EVs) emerging as a focal area. EVs are nanosized, cell-derived particle...
Thiophene derivative-loaded nanoparticles mediate anticancer activity through the inhibition of kinases and microtubule assembly [0.03%]
噻吩衍生物载荷的纳米颗粒通过抑制激酶和微管装配介导抗肿瘤活性
Somaya A Abdel-Rahman,Emad I Wafa,Kareem Ebeid et al.
Somaya A Abdel-Rahman et al.
Different tetrahydrobenzo[b]thiophene derivatives were explored as new tubulin polymerization destabilizers to arrest tumor cell mitosis. A series of compounds incorporating the tetrahydrobenzo[b]thiophene scaffold were synthesized, and the...
Clinically translatable formulation strategies for systemic administration of nerve-specific probes [0.03%]
适用于神经特异性探针全身给药的临床可转化制备策略
Connor W Barth,Vidhi M Shah,Lei G Wang et al.
Connor W Barth et al.
Nerves are extremely difficult to identify and are often accidently damaged during surgery, leaving patients with lasting pain and numbness. Herein, a novel near-infrared (NIR) nerve-specific fluorophore, LGW01-08, was utilized for enhanced...
Impact of crystalline and amorphous matrices on successful spray drying of siRNA polyplexes for inhalation of nano-in-microparticles [0.03%]
微晶和无定形基质对喷雾干燥siRNA聚复合物制备纳米粒吸入给药的影响研究
Tobias Wm Keil,Christoph Zimmermann,Domizia Baldassi et al.
Tobias Wm Keil et al.
To develop stable and inhalable dry powder formulations with long shelf life, we spray dried polyplexes consisting of siRNA and a polyethylenimine based block copolymer in presence of mannitol or trehalose. We investigated the effect of inl...
pH-Responsive STING-Activating DNA Nanovaccines for Cancer Immunotherapy [0.03%]
用于癌症免疫治疗的pH响应性STING激活DNA纳米疫苗
Yu Zhang,Tingting Shen,Shurong Zhou et al.
Yu Zhang et al.
Cyclic dinucleotides (CDNs), such as c-di-GMP (CDG), are agonists for stimulator of interferon genes (STING) and are promising for cancer immunotherapy. Yet, the therapeutic efficacy of CDNs has been limited by poor delivery and biostabilit...