Nanoparticle-Mediated Delivery of Micheliolide Analogs to Eliminate Leukemic Stem Cells in the Bone Marrow [0.03%]
纳米颗粒介导米歇利醇类似物输送以消除骨髓中的白血病干细胞
Marian A Ackun-Farmmer,Hanan Alwaseem,Michele Counts et al.
Marian A Ackun-Farmmer et al.
Micheliolide (MCL) is a naturally occurring sesquiterpene lactone that selectively targets leukemic stem cells (LSCs), which persist after conventional chemotherapy for myeloid leukemias, leading to disease relapse. To overcome modest MCL c...
Self-Assembled Peptide Amphiphile Nanofibers for Controlled Therapeutic Delivery to the Atherosclerotic Niche [0.03%]
自组装肽两亲分子纳米纤维在动脉粥样硬化部位控制药物递送中的应用
Erica B Peters,Mark R Karver,Kui Sun et al.
Erica B Peters et al.
Atherosclerotic plaque remains the leading contributor to cardiovascular disease and requires invasive surgical procedures for its removal. Nanomedicine offers a minimally invasive approach to alleviate plaque burden by targeted therapeutic...
Jessica C Joyce,Marcus L Collins,Paul A Rota et al.
Jessica C Joyce et al.
Measles and rubella vaccinations are highly effective at reducing disease prevalence; however, logistic issues related to subcutaneous administration and vaccine wastage limit the extent of vaccination coverage. Microneedle (MN) patches can...
Chaoyang Meng,Zhe Chen,Junhua Mai et al.
Chaoyang Meng et al.
An effective therapeutic cancer vaccine should be empowered with the capacity to overcome the immunosuppressive tumor microenvironment. Here, the authors describe a mRNA virus-mimicking vaccine platform that is comprised of a phospholipid b...
Erratum: Drug Repurposing for the Treatment of COVID-19: A Knowledge Graph Approach [0.03%]
Correction: 用于治疗COVID-19的药物再利用：知识图谱方法
Vincent K C Yan,Xiaodong Li,Xuxiao Ye et al.
Vincent K C Yan et al.
[This corrects the article DOI: 10.1002/adtp.202100055.]. © 2021 Wiley‐VCH GmbH.
Published Erratum
Advanced therapeutics. 2021 Oct;4(10):2100179. DOI:10.1002/adtp.202100179 2021
Engineering Strategies for Immunomodulatory Cytokine Therapies - Challenges and Clinical Progress [0.03%]
用于免疫调节细胞因子治疗的工程策略 - 挑战和临床进展
Ivan S Pires,Paula T Hammond,Darrell J Irvine
Ivan S Pires
Cytokines are immunoregulatory proteins involved in many pathological states with promising potential as therapeutic agents. A diverse array of cytokines have been studied in preclinical disease models since the 1950s, some of which became ...
Optimization of microbubble-based DNA vaccination with low-frequency ultrasound for enhanced cancer immunotherapy [0.03%]
基于微泡的DNA疫苗优化以低频超声波增强癌症免疫治疗
Nisi Zhang,Josquin Foiret,Azadeh Kheirolomoom et al.
Nisi Zhang et al.
Immunotherapy is an important cancer treatment strategy; nevertheless, the lack of robust immune cell infiltration in the tumor microenvironment remains a factor in limiting patient response rates. In vivo gene delivery protocols can amplif...
Shreyas N Dahotre,Anna M Romanov,Fang-Yi Su et al.
Shreyas N Dahotre et al.
Adoptive T cell therapies are transforming the treatment of solid and liquid tumors, yet their widespread adoption is limited in part by the challenge of generating functional cells. T cell activation and expansion using conventional antige...
A single-dose, implant-based, trivalent virus-like particle vaccine against "cholesterol checkpoint" proteins [0.03%]
针对“胆固醇检查点”蛋白的单剂量植入式三价类病毒颗粒疫苗
Oscar A Ortega-Rivera,Jonathan K Pokorski,Nicole F Steinmetz
Oscar A Ortega-Rivera
Cardiovascular disease is the number one cause of death globally. Lowering cholesterol levels in plasma is the mainstay therapy; however lifelong treatment and adverse effects call for improved therapeutic interventions. We developed a triv...
Peritumoral Delivery of Docetaxel-TIPS Microparticles for Prostate Cancer Adjuvant Therapy [0.03%]
用于前列腺癌辅助治疗的道克塔赛-TIPS微粒物周递送技术
Ketevan Paliashvili,Alexander Popov,Tammy L Kalber et al.
Ketevan Paliashvili et al.
Recurrence of prostate cancer after radical prostatectomy is a consequence of incomplete tumor resection. Systemic chemotherapy after surgery is associated with significant toxicity. Improved delivery methods for toxic drugs capable of targ...