Classical Complement Pathway Inhibition in a "Human-On-A-Chip" Model of Autoimmune Demyelinating Neuropathies [0.03%]
自身免疫性脱髓鞘神经病的"人体芯片"模型中的经典补体途径抑制作用
John W Rumsey,Case Lorance,Max Jackson et al.
John W Rumsey et al.
Chronic autoimmune demyelinating neuropathies are a group of rare neuromuscular disorders with complex, poorly characterized etiology. Here we describe a phenotypic, human-on-a-chip (HoaC) electrical conduction model of two rare autoimmune ...
Recent Developments in Drug Delivery for Treatment of Tuberculosis by Targeting Macrophages [0.03%]
靶向巨噬细胞的药物递送系统在结核病治疗中的最新研究进展
Anirudh Gairola,Aaron Benjamin,Joshua D Weatherston et al.
Anirudh Gairola et al.
Tuberculosis (TB) is among the greatest public health and safety concerns in the 21st century, Mycobacterium tuberculosis, which causes TB, infects alveolar macrophages and uses these cells as one of its primary sites of replication. The cu...
Extending drug release from implants via transcutaneous refilling with solid therapeutics [0.03%]
通过经皮给药输送固体药物延长植入剂的释药周期
Nicola Di Trani,Fernanda P Pons-Faudoa,Antons Sizovs et al.
Nicola Di Trani et al.
Long-acting (LA) implantable drug delivery systems (IDDS) offer an effective approach for the management or prevention of chronic conditions by sustained parenteral therapeutic administration. LA IDDS can and improve adherence to treatment ...
Dimethylaminomicheliolide Sensitizes Cancer Cells to Radiotherapy for Synergistic Combination with Immune Checkpoint Blockade [0.03%]
二甲氨基米格立醇使癌细胞对放疗敏感并协同阻断免疫检查点治疗
Yingying Li,Kaiyuan Ni,Christina Chan et al.
Yingying Li et al.
Radiotherapy (RT) has demonstrated synergy with immune checkpoint blockade (ICB) in preclinical models. However, its potential as an immunoadjuvant is limited by low immunogenicity at low radiation doses and immunosuppression at high radiat...
Rational Design of Polyglutamic Acid Delivering an Optimized Combination of Drugs Targeting Mutated BRAF and MEK in Melanoma [0.03%]
优化联合药物递送设计用于治疗黑色素瘤的理性聚谷氨酸疗法
Evgeni Pisarevsky,Rachel Blau,Yana Epshtein et al.
Evgeni Pisarevsky et al.
Targeted therapies against cancer can relieve symptoms and induce remission, however, they often present limited duration of disease control, cause side effects and often induce acquired resistance. Therefore, there is a great motivation to...
Functionalized Polymers Enhance Permeability of Antibiotics in Gram-negative MDR Bacteria and Biofilms for Synergistic Antimicrobial Therapy [0.03%]
功能化聚合物增强革兰氏阴性多重耐药菌和生物膜中抗生素的通透性以实现协同抗菌疗法
Akash Gupta,Jessa Marie Valenzuela Makabenta,Friederike Schlüter et al.
Akash Gupta et al.
The emergence of multi-drug resistant pathogenic bacteria constitutes a key threat to global health. Infections caused by multi-drug resistant Gram-negative bacteria are particularly challenging to treat due to the ability of pathogens to p...
Light-Triggered Drug Release from Red Blood Cells Suppresses Arthritic Inflammation [0.03%]
光线触发的药物释放：红细胞抑制关节炎炎症
Emilia M Zywot,Natalia Orlova,Song Ding et al.
Emilia M Zywot et al.
Arthritis is a leading cause of disability in adults, which can be intensely incapacitating. The location and intensity of the pain is both subjective and challenging to manage. Consequently, patient-directed delivery of anti-inflammatories...
Indocyanine Green-Coated Gold Nanoclusters for Photoacoustic Imaging and Photothermal Therapy [0.03%]
用于光声成像和光热治疗的吲哚青绿包覆型金质纳米颗粒
Elizabeth Higbee-Dempsey,Ahmad Amirshaghaghi,Matthew J Case et al.
Elizabeth Higbee-Dempsey et al.
Traditional oncology treatment modalities are often associated with a poor therapeutic index. This has driven the development of new targeted treatment modalities, including several based on the conversion of optical light into heat energy ...
Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin-Wound Infections [0.03%]
抑制枯草芽孢杆菌胶原酶Q1作为治疗皮肤伤口感染的新抑菌策略
Alaa Alhayek,Essak S Khan,Esther Schönauer et al.
Alaa Alhayek et al.
Despite the progress in surgical techniques and antibiotic prophylaxis, opportunistic wound infections with Bacillus cereus remain a public health problem. Secreted toxins are one of the main factors contributing to B. cereus pathogenicity....
Development of Dual Receptor Enhanced Pre-Targeting Strategy-A Novel Promising Technology for Immuno-Positron Emission Tomography Imaging [0.03%]
用于免疫正电子发射断层扫描成像的双受体增强型预靶向策略的发展-一种有前景的新技术
Lingyi Sun,Yongkang Gai,Zhonghan Li et al.
Lingyi Sun et al.
PET imaging has become an important diagnostic tool in the era of precise medicine. Various pre-targeting systems have been reported to address limitations associated with traditional immuno-PET. However, the application of these mono-recep...