Functionalized core-shell nanogel scavenger for immune modulation therapy in sepsis [0.03%]
用于脓毒症免疫调节治疗的功能化核壳纳米凝胶清除剂
Xiaotian Ji,Xiguang Yang,Changying Shi et al.
Xiaotian Ji et al.
Sepsis is a complex, life-threatening hyperinflammatory syndrome associated with organ failure and high mortality due to lack of effective treatment options. Here we report a core-shell hydrogel nanoparticle with the core functionalized wit...
Novel DZ-SIM Conjugate Targets Cancer Mitochondria and Prolongs Survival in Pancreatic Ductal Adenocarcinoma [0.03%]
新型DZ-SIM偶联物靶向癌症线粒体并延长胰腺导管腺癌生存期
Yan Ou,Ruoxiang Wang,Gina Chia-Yi Chu et al.
Yan Ou et al.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with no effective therapeutics. We have developed a novel targeted therapy drug consisting of a tumor-targeting ligand, near-infrared (NIR) organic heptamethine carbocyanine dye (HMCD), a...
A Computational Model of Cytokine Release Syndrome during CAR T-cell Therapy [0.03%]
CAR T细胞治疗过程中细胞因子释放综合症的计算模型
Zhuoyu Zhang,Lunan Liu,Chao Ma et al.
Zhuoyu Zhang et al.
Cytokine release syndrome (CRS) is a lethal adverse event in chimeric antigen receptor (CAR) T-cell therapy, hindering this promising therapy for cancers, such as B-cell acute lymphoblastic leukemia (B-ALL). Clinical management of CRS requi...
An induced pluripotent stem cell-derived NMJ platform for study of the NGLY1-Congenital Disorder of Deglycosylation [0.03%]
用于研究NGLY1-先天性去糖基化障碍的诱导多能干细胞衍生的神经肌肉接头平台
Trevor Sasserath,Ashley L Robertson,Roxana Mendez et al.
Trevor Sasserath et al.
There are many neurological rare diseases where animal models have proven inadequate or do not currently exist. NGLY1 Deficiency, a congenital disorder of deglycosylation, is a rare disease that predominantly affects motor control, especial...
Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke [0.03%]
粒子水凝胶减少中风后的脑萎缩并减弱星形胶质细胞和小胶质/巨噬细胞反应性
Elias Sideris,Sophia Kioulaphides,Katrina Wilson et al.
Elias Sideris et al.
Increasing numbers of individuals live with stroke related disabilities. Following stroke, highly reactive astrocytes and pro-inflammatory microglia can release cytokines and lead to a cytotoxic environment that causes further brain damage ...
A single-dose Qβ VLP vaccine against S100A9 protein reduces atherosclerosis in a preclinical model [0.03%]
针对S100A9蛋白的单剂量Qβ VLP疫苗可减少临床前模型中的动脉粥样硬化
Oscar A Ortega-Rivera,Matthew D Shin,Miguel A Moreno-Gonzalez et al.
Oscar A Ortega-Rivera et al.
The standard therapy for cardiovascular disease (CVD) is the administration of statins to reduce plasma cholesterol levels, but this requires lifelong treatment. We developed a CVD vaccine candidate that targets the pro-inflammatory mediato...
Delivery of Dissociated Islets Cells within Microporous Annealed Particle Scaffold to Treat Type 1 Diabetes [0.03%]
用于治疗1型糖尿病的 dissociated 胰岛细胞微孔退火颗粒支架传输技术
Colleen A Roosa,Mingyang Ma,Preeti Chhabra et al.
Colleen A Roosa et al.
Type 1 diabetes (T1D) is caused by the autoimmune loss of insulin-producing beta cells in the pancreas. The only clinical approach to patient management of blood glucose that doesn't require exogenous insulin is pancreas or islet transplant...
Co-Anchoring of Engineered Immunogen and Immunostimulatory Cytokines to Alum Promotes Enhanced-Humoral Immunity [0.03%]
工程化免疫原和免疫刺激细胞因子共锚定铝佐剂促进增强的体液免疫
Jason Y H Chang,Yash Agarwal,Kristen A Rodrigues et al.
Jason Y H Chang et al.
Protein antigens are often combined with aluminum hydroxide (alum), the most commonly used adjuvant in licensed vaccines; yet the immunogenicity of alum-adjuvanted vaccines leaves much room for improvement. Here, the authors demonstrate a s...
Efficacy and Safety of Inosine Pranobex in COVID-19 Patients: A Multicenter Phase 3 Randomized Double-Blind, Placebo-Controlled Trial [0.03%]
匹诺贝克斯治疗新冠肺炎患者的疗效和安全性：多中心随机双盲安慰剂对照三期临床试验
Jayanthi C R,Ashok K Swain,Ranganath T Ganga et al.
Jayanthi C R et al.
Inosine pranobex (IP), an immunomodulatory agent, is used in the treatment of various viral infections. The results of a phase 3 randomized controlled trial are reported, evaluating the efficacy and safety of IP in the treatment of mild to ...
Inhaled Gold Nano-star Carriers for Targeted Delivery of Triple Suicide Gene Therapy and Therapeutic MicroRNAs to Lung Metastases: Development and Validation in a Small Animal Model [0.03%]
一种用于向肺转移瘤靶向递送三重自杀基因疗法和治疗性微小核糖核酸的金纳米星载体：在小型动物模型中的开发与验证
Yi Liu,Uday Kumar Sukumar,Natacha Jugniot et al.
Yi Liu et al.
Pulmonary metastases pose significant treatment challenges for many cancers, including triple-negative breast cancer (TNBC). We developed and tested a novel suicide gene and therapeutic microRNAs (miRs) combination therapy against lung meta...