Biodegradable Polyester Nanoparticle Vaccines Deliver Self-Amplifying mRNA in Mice at Low Doses [0.03%]
可降解聚酯纳米颗粒疫苗可在低剂量下向小鼠递送自我增效型信使rna
David R Wilson,Stephany Y Tzeng,Yuan Rui et al.
David R Wilson et al.
Delivery of self-amplifying mRNA (SAM) has high potential for infectious disease vaccination due its self-adjuvating and dose-sparing properties. Yet a challenge is the susceptibility of SAM to degradation and the need for SAM to reach the ...
Drug Permeability: From the Blood-Brain Barrier to the Peripheral Nerve Barriers [0.03%]
从血脑屏障到外周神经屏障的药物渗透性研究进展
Yifei Sun,Mahmood Zabihi,Qi Li et al.
Yifei Sun et al.
Drug delivery into the peripheral nerves and nerve roots has important implications for effective local anesthesia and treatment of peripheral neuropathies and chronic neuropathic pain. Similar to drugs that need to cross the blood-brain ba...
Engineered Vasculogenic Extracellular Vesicles Drive Nonviral Direct Conversions of Human Dermal Fibroblasts into Induced Endothelial Cells and Improve Wound Closure [0.03%]
工程化的血管生成细胞外囊泡驱动人成纤维细胞直接转化为诱导内皮细胞并改善伤口闭合
Maria A Rincon-Benavides,Natalia Claire Mendonca,Tatiana Z Cuellar-Gaviria et al.
Maria A Rincon-Benavides et al.
Vasculogenic cell therapies have emerged as a powerful tool to increase vascularization and promote tissue repair/regeneration. Current approaches to cell therapies, however, rely mostly on progenitor cells, which pose significant risks (e....
In Vivo Activity of Hydrogen-Peroxide Generating Electrochemical Bandage Against Murine Wound Infections [0.03%]
一种产过氧化氢的电化学绷带对小鼠创面感染的疗效
Yash S Raval,Derek Fleming,Abdelrhman Mohamed et al.
Yash S Raval et al.
Biofilms formed by antibiotic-resistant bacteria in wound beds present unique challenges in terms of treating wound infections. In this work, the in vivo activity of a novel electrochemical bandage (e-bandage) composed of carbon fabric and ...
Transfection with nanostructure electro-injection is minimally perturbative [0.03%]
利用纳米结构电转染进行基因转染对细胞扰动小
Andy Tay,Nicholas Melosh
Andy Tay
Transfection is a critical step for gene editing and cell-based therapies. Nanoscale technologies have shown great promise to provide higher transfection efficiency and lower cell perturbation than conventional viral, biochemical and electr...
Engineered Ultrasmall Nanoparticle Drug-Immune Conjugates with "Hit and Run" Tumor Delivery to Eradicate Gastric Cancer [0.03%]
工程化超小型纳米颗粒药物免疫偶联物实现胃癌的“一击即走”式精准治疗
Li Zhang,Virginia Aragon-Sanabria,Anusha Aditya et al.
Li Zhang et al.
Despite advances by recently approved antibody-drug conjugates in treating advanced gastric cancer patients, substantial limitations remain. Here, several key obstacles are overcome by developing a first-in-class ultrasmall (sub-8-nanometer...
Emulsion-induced polymersomes taming tetrodotoxin for prolonged duration local anesthesia [0.03%]
乳液诱导的聚合物囊泡缓释四氢托品用于长效局部麻醉
Xiaosi Li,Qi Li,Shenghan Song et al.
Xiaosi Li et al.
Injectable local anesthetics that can provide a continuous nerve block approximating the duration of a pain state would be a life-changing solution for patients experiencing post-operative pain or chronic pain. Tetrodotoxin (TTX) is a site ...
Identification of an ALK-2 inhibitor as an agonist for intercellular exchange and tumor delivery of nanomaterial [0.03%]
ALK-2抑制剂作为纳米材料细胞间交换和肿瘤递送的激动剂鉴定
Xian Wu,Hong Guo,Jiaqi Zhao et al.
Xian Wu et al.
Inefficient extravasation and penetration in solid tissues hinder the clinical outcome of nanoparticles (NPs). Recent studies have shown that the extravasation and penetration of NPs in solid tumor was mostly achieved via an active transcel...
Cell-free, Dendritic Cell-mimicking Extracellular Blebs for Molecularly Controlled Vaccination [0.03%]
无细胞、树突状细胞模拟的胞浆外泡用于分子控制疫苗接种
Melissa N Thone,Jee Young Chung,Dominique Ingato et al.
Melissa N Thone et al.
Dendritic cells (DCs) are prime targets for vaccination and immunotherapy. However, limited control over antigen presentation at a desired maturation status in these plastic materials remains a fundamental challenge in efficiently orchestra...
Stable High-Concentration Monoclonal Antibody Formulations Enabled by an Amphiphilic Copolymer Excipient [0.03%]
由两亲性嵌段共聚物辅料实现的高浓度单克隆抗体稳定制剂
John H Klich,Catherine M Kasse,Joseph L Mann et al.
John H Klich et al.
Monoclonal antibodies are a staple in modern pharmacotherapy. Unfortunately, these biopharmaceuticals are limited by their tendency to aggregate in formulation, resulting in poor stability and often requiring low concentration drug formulat...