In vitro assessment of protamine toxicity with neural cells, its therapeutic potential to counter chondroitin sulfate mediated neuron inhibition, and its effects on reactive astrocytes [0.03%]
用神经细胞体外评估鱼精蛋白毒性、其治疗潜力以对抗硫酸软骨素介导的神经元抑制及对活性星形胶质细胞的影响
Derek W Nelson,Jessica L Funnell,Conrad H Cheung et al.
Derek W Nelson et al.
Multiple therapies have been studied to ameliorate the neuroinhibitory cues present after traumatic injury to the central nervous system. Two previous in vitro studies have demonstrated the efficacy of the FDA-approved cardiovascular therap...
Antibody and siRNA Nanocarriers to Suppress Wnt Signaling, Tumor Growth, and Lung Metastasis in Triple-Negative Breast Cancer [0.03%]
三阴性乳腺癌中抗体和siRNA纳米载体抑制Wnt信号、肿瘤生长及肺部转移
Megan N Dang,Sejal Suri,Kejian Li et al.
Megan N Dang et al.
The paucity of targeted therapies for triple-negative breast cancer (TNBC) causes patients with this aggressive disease to suffer a poor clinical prognosis. A promising target for therapeutic intervention is the Wnt signaling pathway, which...
Pharmacokinetics and Biodistribution of Phages and their Current Applications in Antimicrobial Therapy [0.03%]
噬菌体的药代动力学、生物分布及其在抗菌治疗中的应用
Dayeon Kang,Damayanti Bagchi,Irene A Chen
Dayeon Kang
Antimicrobial resistance remains a critical global health concern, necessitating the investigation of alternative therapeutic approaches. With the diminished efficacy of conventional small molecule drugs due to the emergence of highly resil...
Bio-orthogonal, Site-Selective Conjugation of Recombinant Proteins to Microporous Annealed Particle Hydrogels for Tissue Engineering [0.03%]
生物正交位点选择性结合重组蛋白到微孔热解颗粒水凝胶中以进行组织工程研究
Faraz Jivan,Daniel L Alge
Faraz Jivan
Protein conjugation to biomaterial scaffolds is a powerful approach for tissue engineering. However, typical chemical conjugation methods lack site-selectivity and can negatively impact protein bioactivity. To overcome this problem, a site-...
Danielle E Large,Jonathan R Soucy,Jacob Hebert et al.
Danielle E Large et al.
Receptor-mediated drug delivery presents an opportunity to enhance therapeutic efficiency by accumulating drug within the tissue of interest and reducing undesired, off-target effects. In cancer, receptor overexpression is a platform for bi...
Discovery of Anti-CD47 Peptides as Innate Immune Checkpoint Inhibitors [0.03%]
抗原呈递细胞表面分子CD47的拮抗肽作为天然免疫阻断剂的研究发现
Bahaa Mustafa,John Fetse,Sashi Kandel et al.
Bahaa Mustafa et al.
Cancer immunotherapy targeting adaptive immune cells has been attracting considerable interest due to its great success in treating multiple cancers. Recently, there is also increasing interest in agents that can stimulate innate immune cel...
Antioxidant theranostic copolymer-mediated reduction in oxidative stress following traumatic brain injury improves outcome in a mouse model [0.03%]
抗氧化治疗诊断共聚物介导的创伤性脑损伤后氧化应激减少改善了小鼠模型的结果
Aria W Tarudji,Connor C Gee,Hunter A Miller et al.
Aria W Tarudji et al.
Following a traumatic brain injury (TBI), excess reactive oxygen species (ROS) and lipid peroxidation products (LPOx) are generated and lead to secondary injury beyond the primary insult. A major limitation of current treatments is poor tar...
Robust anti-tumor T cell response with efficient intratumoral infiltration by nanodisc cancer immunotherapy [0.03%]
纳米盘癌症免疫疗法引发的具有高效肿瘤内浸润的 robust 抗肿瘤T细胞反应
Rui Kuai,Priti B Singh,Xiaoqi Sun et al.
Rui Kuai et al.
Potent anti-tumor T cell response and efficient intratumoral T cell infiltration are the major challenges for therapeutic cancer vaccines. To address these issues, a nano-vaccine system has been designed to promote anti-tumor T cell respons...
Yurui Wang,Yiran Song,Yazhi He et al.
Yurui Wang et al.
The immune system plays a crucial role in recognizing and eliminating pathogenic substances and malignant cells in the body. For cancer treatment, immunotherapy is becoming the standard treatment for many types of cancer and is often combin...
Comparison of SGLT1, SGLT2, and Dual Inhibitor biological activity in treating Type 2 Diabetes Mellitus [0.03%]
SGLT1、SGLT2和双重抑制剂在治疗二型糖尿病中的生物活性比较研究
Abdul-Rahman Azizogli,Michael R Vitti,Richa Mishra et al.
Abdul-Rahman Azizogli et al.
Diabetes Mellitus Type 2 (T2D) is an emerging health burden in the USand worldwide, impacting approximately 15% of Americans. Current front-line therapeutics for T2D patients include sulfonylureas that act to reduce A1C and/or fasting blood...