Spatiotemporal control of immune responses with nucleic acid cocktail vaccine [0.03%]
基于核酸鸡尾酒疫苗的免疫反应时空控制
Chunxi Wang,Andrew N Macintyre,Thomas H Oguin rd et al.
Chunxi Wang et al.
Nucleic acid vaccines play important roles in prevention and treatment of diseases. However, limited immunogenicity remains a major obstacle for DNA vaccine applications in the clinic. To address the issue, the present study investigates a ...
Targeting glioblastoma tumor hyaluronan to enhance therapeutic interventions that regulate metabolic cell properties [0.03%]
靶向胶质母细胞瘤肿瘤透明质酸以增强调节代谢细胞属性的治疗方法
Edward R Neves,Achal Anand,Joseph Mueller et al.
Edward R Neves et al.
Despite extensive advances in cancer research, glioblastoma (GBM) still remains a very locally invasive and thus challenging tumor to treat, with a poor median survival. Tumor cells remodel their microenvironment and utilize extracellular m...
Uncovering the Elusive Structures and Mechanisms of Prevalent Antidepressants [0.03%]
揭开广泛使用的抗抑郁药物的结构和机制之谜
Jieye Lin,Guanhong Bu,Johan Unge et al.
Jieye Lin et al.
Most treatments to alleviate major depression work by either inhibiting human monoamine transporters, vital for the reuptake of monoamine neurotransmitters, or by inhibiting monoamine oxidases, which are vital for their degradation. The ana...
Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration [0.03%]
关于生物材料在骨再生过程中调控破骨细胞分化和功能的线索研究
Kaavian Shariati,Meiwand Bedar,Kelly X Huang et al.
Kaavian Shariati et al.
Tissue regeneration involves dynamic dialogue between and among different cells and their surrounding matrices. Bone regeneration is specifically governed by reciprocity between osteoblasts and osteoclasts within the bone microenvironment. ...
Mitali Kini,Matthew I Bury,Arun K Sharma
Mitali Kini
Impaired bladder compliance secondary to congenital or acquired bladder dysfunction can lead to irreversible kidney damage. This is managed with surgical augmentation utilizing intestinal tissue, which can cause stone formation, infections,...
Evaluation of Bioprinted Autologous Cartilage Grafts in an Immunocompetent Rabbit Model [0.03%]
免疫健全兔模型中生物打印自体软骨移植物的评估
David Gvaramia,Philipp Fisch,Killian Flégeau et al.
David Gvaramia et al.
The gold standard of auricular reconstruction involves manual graft assembly from autologous costal cartilage. The intervention may require multiple surgical procedures and lead to donor-site morbidity, while the outcome is highly dependent...
Controlled Delivery of Paclitaxel via Stable Synthetic Protein Nanoparticles [0.03%]
基于稳定合成蛋白质纳米颗粒的紫杉醇可控释放
Ava Mauser,Isabel Waibel,Kaushik Banerjee et al.
Ava Mauser et al.
Despite decades of intense research, glioma remains a disease for which no adequate clinical treatment exists. Given the ongoing therapeutic failures of conventional treatment approaches, nanomedicine may offer alternative options because i...
Single-Administration Self-Boosting Microneedle Patch for The Treatment of Obesity [0.03%]
用于治疗肥胖的单次使用微针贴片疗法
Parbeen Singh,Tra Vinikoor,Nidhi Sharma et al.
Parbeen Singh et al.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are one of the most effective treatments for obesity. The current therapy associated with repeated subcutaneous injections to maintain the drug therapeutic effect causes patient complian...
Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor-Targeted Drug Delivery [0.03%]
他莫昔芬的重新定位：用于肿瘤微环境的预处理和增强肿瘤靶向药物递送
Ilaria Biancacci,Daniele De Santis,Elena Rama et al.
Ilaria Biancacci et al.
The dense stromal matrix in fibrotic tumors hinders tumor-targeted drug delivery. Tamoxifen (TMX), an estrogen receptor modulator that is clinically used for the treatment of breast cancer, has been shown to reprogram the tumor microenviron...
A Facile Approach to Producing Liposomal J-Aggregates of Indocyanine Green with Diagnostic and Therapeutic Potential [0.03%]
一种制备吲哚青绿J型聚合物脂质体的简易方法及其在诊断和治疗中的应用研究
Noah B Stern,Binita Shrestha,Tyrone Porter
Noah B Stern
Liposomal J-Aggregates of Indocyanine Green (L-JA) can serve as a biocompatible and biodegradable nanoparticle for photoacoustic imaging and photothermal therapy. When compared to monomeric IcG, L-JA are characterized by longer circulation,...