Stable Monomeric Insulin Formulations Enabled by Supramolecular PEGylation of Insulin Analogues [0.03%]
超分子PEG化胰岛素类似物实现稳定的单体胰岛素配方
Caitlin L Maikawa,Anton A A Smith,Lei Zou et al.
Caitlin L Maikawa et al.
Current "fast-acting" insulin analogues contain amino acid modifications meant to inhibit dimer formation and shift the equilibrium of association states toward the monomeric state. However, the insulin monomer is highly unstable and curren...
Genetic Hallmarks and Heterogeneity of Glioblastoma in the Single-Cell Omics Era [0.03%]
单细胞组学时代胶质母细胞瘤的遗传特征和异质性
Andrea Degl&#x;Innocenti,Nicoletta di Leo,Gianni Ciofani
Andrea Degl&#x;Innocenti
Glioblastoma multiforme is the most common and aggressive malignant primary brain tumor. As implied by its name, the disease displays impressive intrinsic heterogeneity. Among other complications, inter- and intratumoral diversity hamper gl...
Decellularized Extracellular Matrix Hydrogels as a Delivery Platform for MicroRNA and Extracellular Vesicle Therapeutics [0.03%]
脱细胞基质水凝胶作为递送微小核糖核酸和外泌体的药物输送平台
Melissa J Hernandez,Roberto Gaetani,Vera M Pieters et al.
Melissa J Hernandez et al.
In the last decade, the use of microRNA (miRNA) and extracellular vesicle (EV) therapies has emerged as an alternative approach to mitigate the negative effects of several disease pathologies ranging from cancer to tissue and organ regenera...
Crosslinked Chitosan-PEG Hydrogel for Culture of Human Glioblastoma Cell Spheroids and Drug Screening [0.03%]
用于人类胶质母细胞瘤细胞球培养和药物筛选的交联壳聚糖-Peg水凝胶
Fei-Chien Chang,Sheeny Lan Levengood,Nick Cho et al.
Fei-Chien Chang et al.
Two-dimensional monolayer cell cultures are routinely utilized for preclinical cancer drug screening, but the results often do not translate well when drugs are tested in vivo. To address this limitation, a biocompatible chitosan-PEG hydrog...
Coming in and Finding Out: Blending Receptor-Targeted Delivery and Efficient Endosomal Escape in a Novel Bio-Responsive siRNA Delivery System for Gene Knockdown in Pulmonary T Cells [0.03%]
一种用于肺T细胞基因敲除的新型生物响应siRNA递送系统中受体靶向递送和高效溶酶体逃逸相结合的研究
Rima Kandil,Yuran Xie,Ralf Heermann et al.
Rima Kandil et al.
RNA interference (RNAi) offers the potential to selectively silence disease-related genes in defined cell subsets. Translation into the clinical routine is, however, still hampered by the lack of efficient carrier systems for therapeutic si...
R S Oakes,E Froimchuk,C M Jewell
R S Oakes
Small alterations during early stages of innate immune response can drive large changes in how adaptive immune cells develop and function during protective immunity or disease. Controlling these events creates exciting potential in developm...
Coating nanoparticles with gastric epithelial cell membrane for targeted antibiotic delivery against Helicobacter pylori infection [0.03%]
胃上皮细胞膜包被的纳米粒子用于根除幽门螺旋杆菌的定向给药抗生素疗法
Pavimol Angsantikul,Soracha Thamphiwatana,Qiangzhe Zhang et al.
Pavimol Angsantikul et al.
Inspired by the natural pathogen-host interactions and adhesion, this study reports on the development of a novel targeted nanotherapeutics for the treatment of Helicobacter pylori (H. pylori) infection. Specifically, plasma membranes of ga...