Haodong Guo,Lili Zhou,Zhenyu Ma et al.
Haodong Guo et al.
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a severe pandemic and deeply affected the livelihood of people worldwide. In response to the pandemic, researchers have ...
Ziwen Jiang,S Thayumanavan
Ziwen Jiang
Nucleic acid delivery provides effective options to control intracellular gene expression and protein production. Efficient delivery of nucleic acid typically requires delivery vehicles to facilitate the entry of nucleic acid into cells. Am...
An Antigen-Delivery Protein Nanoparticle Combined with Anti-PD-1 Checkpoint Inhibitor Has Curative Efficacy in an Aggressive Melanoma Model [0.03%]
一种抗原递呈蛋白纳米颗粒联合抗PD-1免疫检查点抑制剂在小鼠恶性黑色素瘤模型中具有治愈效果
Medea Neek,Jo Anne Tucker,Nina Butkovich et al.
Medea Neek et al.
Immune checkpoint inhibition is a promising alternative treatment to standard chemotherapies; however, it fails to achieve long-term remission in a significant portion of patients. A previously developed protein nanoparticle-based platform ...
Synthetic platelet microgels containing fibrin knob B mimetic motifs enhance clotting responses [0.03%]
含纤溶素凸点B模体的合成血小板微凝胶增强凝血反应
Seema Nandi,Emily Mihalko,Kimberly Nellenbach et al.
Seema Nandi et al.
Native platelets are crucial players in wound healing. Key to their role is the ability of their surface receptor GPIIb/IIIa to bind fibrin at injury sites, thereby promoting clotting. When platelet activity is impaired as a result of traum...
In Vivo Editing of Macrophages through Systemic Delivery of CRISPR-Cas9-Ribonucleoprotein-Nanoparticle Nanoassemblies [0.03%]
基于CRISPR-Cas9的纳米颗粒宏组装体内编辑巨噬细胞
Yi-Wei Lee,Rubul Mout,David C Luther et al.
Yi-Wei Lee et al.
Macrophages are key effectors of host defense and metabolism, making them promising targets for transient genetic therapy. Gene editing through delivery of the Cas9-ribonucleoprotein (RNP) provides multiple advantages over gene delivery-bas...
Peter D Koch,Jeremy Quintana,Maaz Ahmed et al.
Peter D Koch et al.
Multiple potent covalent inhibitors for mutant KRAS G12C have been described and some are in clinical trials. These small molecule inhibitors potentially allow for companion imaging probe development, thereby expanding the chemical biology ...
Local Depletion of Immune Checkpoint Ligand CTLA4 Expressing Cells in Tumor Beds Enhances Antitumor Host Immunity [0.03%]
肿瘤细胞浸润区内源性耗竭CTLA4表达细胞可增强宿主抗肿瘤免疫反应
Ryuhei Okada,Takuya Kato,Aki Furusawa et al.
Ryuhei Okada et al.
Near-infrared photoimmunotherapy (NIR-PIT) is a cancer treatment that utilizes antibody-photoabsorber (IR700) conjugates to selectively kill target cells by exposing them to NIR light. Cytotoxic T-lymphocyte antigen 4 (CTLA4) is a major imm...
Bin Sun,Kenneth S Hettie,Shoujun Zhu
Bin Sun
Thrombosis is an adverse physiological event wherein the resulting thrombus and thrombus-induced diseases collectively result in high morbidity and mortality rates. Currently, nano-medicines that incorporate fluorophores emitting in the nea...
Targeting glioblastoma using a novel peptide specific to a deglycosylated isoform of brevican [0.03%]
针对breviscan的脱岩糖基异构体的新型肽治疗胶质母细胞瘤
Niklas von Spreckelsen,Colin M Fadzen,Nina Hartrampf et al.
Niklas von Spreckelsen et al.
Glioblastoma multiforme (GBM) is the most common and deadliest form of brain tumor and remains amongst the most difficult cancers to treat. Brevican (Bcan), a central nervous system (CNS)-specific extracellular matrix protein, is upregulate...
Frances C Knight,John T Wilson
Frances C Knight
In recent years, tissue-resident memory T cells (TRM) have attracted significant attention in the field of vaccine development. Distinct from central and effector memory T cells, TRM cells take up residence in home tissues such as the lung ...