Synthesis of Constrained Heterocycles Employing Two Post-Ugi Cyclization Methods for Rapid Library Generation with In Cellulo Activity [0.03%]
基于两种Ugi反应后环化方法的约束杂环合成及其在细胞内的活性研究
Nicholas McConnell,Zhigang Xu,Vishnu Kumarasamy et al.
Nicholas McConnell et al.
Benzimidazoles and quinoxalinones are present in the core of many pharmacologically relevant compounds. Several combinatorial methods have been developed to attach ring systems to both scaffolds for derivatization at select positions. Herei...
A 'Plug and Play' Platform for the Production of Diverse Monoterpene Hydrocarbon Scaffolds in Escherichia coli [0.03%]
一种“即插即用”平台 在大肠杆菌中生产多种单萜烃支架
Nicole G H Leferink,Adrian J Jervis,Ziga Zebec et al.
Nicole G H Leferink et al.
The terpenoids constitute one of the largest and most diverse classes of natural compounds with applications as pharmaceuticals, flavorings and fragrances, pesticides and biofuels. Synthetic biology is ideally placed to create new routes to...
Divide and Control: Comparison of Split and Switch Hybridization Sensors [0.03%]
分而治之：分裂和切换型杂化传感器的比较
Alexandra L Smith,Dmitry M Kolpashchikov
Alexandra L Smith
Hybridization probes have been intensively used for nucleic acid analysis in medicine, forensics and fundamental research. Instantaneous hybridization probes (IHPs) enable signalling immediately after binding to a targeted DNA or RNA sequen...
Kullapa Chanawanno,Cole Holstrom,Victor N Nemykin et al.
Kullapa Chanawanno et al.
Several new 1,1'-bis(sulfonyl)ferrocenes designed for the synthesis of sulfonamide linked biological conjugates have been prepared. 1,1'-Bis(sulfonylbromide)ferrocene can be produced from the corresponding sulfonylchloride via a bis(sulfony...
Systematic optimization and modification of a DNA aptamer with 2'-O-methyl RNA analogues [0.03%]
通过2'-O-甲基RNA类似物对DNA适配体进行系统的优化和改良
George Maio,Osita Enweronye,Hasan E Zumrut et al.
George Maio et al.
Nucleic acid aptamers (NAAs) are short synthetic DNA or RNA molecules that specifically fold into distinct three-dimensional structures able to specifically recognize a target. While NAAs show unprecedented promise in a variety of applicati...
Facile Synthesis of a Next Generation Safety-Catch Acid-Labile Linker, SCAL-2, Suitable for Solid-Phase Synthesis, On-Support Display and for Post-Synthesis Tagging [0.03%]
适合固相合成、载体展示和合成后标记的下一代安全酸实验室连接物SCAL-2的简易合成法
Christophe Portal,Martin Hintersteiner,Olivier Barbeau et al.
Christophe Portal et al.
The SCAL linker, a safety catch linker, is amongst the most versatile linkers for solid phase synthesis. It was originally described in 1991 by Pátek and Lebl. Yet, its application has been hindered by the low yields of published synthetic...
Formation of Hindered Arylcarbamates using Alkyl Aryl Carbonates under Highly Reactive Conditions [0.03%]
在高反应条件下使用芳基烷基碳酸酯形成受限的芳基碳酰胺
Shahien Shahsavari,James Gooding,Travis Wigstrom et al.
Shahien Shahsavari et al.
Hindered O-tert-alkyl N-arylcarbamates were conveniently prepared by treating arylamines with aryl tert-alkyl carbonates in the presence of a strong base. The new method avoids the use of sensitive and difficult-to-access dialkyl dicarbonat...
On the Catalytic Activity of Pt Supported by Graphyne in the Oxidation of Ethanol [0.03%]
关于石墨烯负载Pt催化乙醇氧化性能的研究
Ge Tian,Zhongnan Qi,Wanyong Ma et al.
Ge Tian et al.
The adsorption of Pt clusters on β- and γ-graphyne (β-GY, γ-GY), graphdiyne (GDY), and graphene (GP) was extensively investigated with density functional theory. Ethanol adsorption and its partial oxidation on the Pt supported by the GY...
Ion Mobility Separations of Isomers based upon Long Path Length Structures for Lossless Ion Manipulations Combined with Mass Spectrometry [0.03%]
基于长路径结构的无损离子操控的离子淌度分离异构体并结合质谱分析技术
Liulin Deng,Yehia M Ibrahim,Erin S Baker et al.
Liulin Deng et al.
Mass spectrometry (MS)-based multi-omic measurements, including proteomics, metabolomics, lipidomics, and glycomics, are increasingly transforming our ability to characterize and understand biological systems. Multi-omic analyses and the de...
NMR Signal Amplification by Reversible Exchange of Sulfur-Heterocyclic Compounds Found In Petroleum [0.03%]
石油中存在的硫杂环化合物的可逆交换放大核磁共振信号
Roman V Shchepin,Danila A Barskiy,Aaron M Coffey et al.
Roman V Shchepin et al.
NMR hyperpolarization via Signal Amplification by Reversible Exchange (SABRE) was employed to investigate the feasibility of enhancing the NMR detection sensitivity of sulfur-heterocycles (specifically 2-methylthiophene and dibenzothiophene...