Single-Benzene-Based Clickable Fluorophores for In Vitro and In Vivo Bioimaging [0.03%]
用于体内外生物成像的基于苯的点击型荧光团
Raja Mohanrao,Clyde S Pinto,Andrejus Suchenko et al.
Raja Mohanrao et al.
A series of miniaturized, clickable single-benzene-based fluorophores derived from tetrafluoroterephthalonitrile is reported. Fluorophores based on a tetrahydroquinoxaline skeleton exhibited improved photophysical properties due to enhanced...
Selenium Adsorption on the (111), (100), (110) and (211) surfaces of Face-Centered-Cubic Metals: Density Functional Calculations of the Potential Energy Surfaces [0.03%]
硒在面心立方金属的(111)，(100)，(110)和(211)表面上的吸附：潜在能面的密度泛函计算
Rolando L Albarracín Rivera,Yomari L Colon-Ruiz,Adriana De La Torre-Rosa et al.
Rolando L Albarracín Rivera et al.
In this study, we expand the computational investigation of selenium, which has previously been limited to metals such as Cu, Fe, Pd, Au, and Pt. Utilizing density functional theory calculations, we explore the adsorption and diffusion of s...
Synthesis and Identification of Heterobivalent Anticancer Compounds Containing Urea and 5-Arylidene-2-Thiohydantoin Motifs [0.03%]
含脲和5-芳基亚胺二硫缩氨脲片段的异二价抗肿瘤化合物的合成与表征
Chelsi Whitely,Haley Winburn,Yangmei Li
Chelsi Whitely
Urea and thiohydantoin are among the important privileged structures for drug discovery. We have developed a synthetic approach to the high-throughput synthesis of the heterobivalent compounds containing both urea and 5-arylidene-2-thiohyda...
Synthesis of Chiral Tricyclic Pyrone Molecules via Palladium(0)-Catalyzed Displacement Reactions of Chiral Tricyclic Pyrone Acetate With Azide or Amine [0.03%]
通过钯催化的位移反应合成手性三环吡酮分子
Shunya Morita,Zhaoyang Ren,Huafang Fan et al.
Shunya Morita et al.
Tricyclic pyrone (TP) molecules have shown protection of MC65 neuroblastoma cells death induced by amyloid-β proteins through SβC gene, a decrease of amyloid-β peptide levels, and improvement of motor functions and memory in Alzheimer's ...
Synthesis of Imide and Amine Derivatives via Deoxyamination of Alcohols Using N-Haloimides and Triphenylphosphine [0.03%]
醇的去氧氨化反应：N-卤亚胺和三苯基磷催化的酰亚胺和胺衍生物的合成
Charles D Irving,Jack T Floreancig,Makafui Gasonoo et al.
Charles D Irving et al.
A deoxyamination methodology of activated and unactivated alcohols is presented. The reaction is mediated by phosphonium intermediates generated in situ from N-haloimides and triphenylphosphine. The protocol allows for the synthesis of phth...
Jay Min Lim,Rahul Tevatia,Ravi F Saraf
Jay Min Lim
Quantitative dysregulation in small nucleic acids (NA), such as microRNA (miRNA), extracted from minimally invasive biopsies, such as, blood, stool, urine, nose, throat, are promising biomarker for diseases diagnosis and management. We quan...
A Series of Adenosine Analogs as the First Efficacious Anti-SARS-CoV-2 Drugs against the B.1.1.529.4 Lineage: A Preclinical Repurposing Research Study [0.03%]
首个针对B.1.1.529.4谱系的高效抗SARS-CoV-2药物——腺苷类似物系列：一项临床再利用研究
Amgad M Rabie,Mohnad Abdalla
Amgad M Rabie
Given the rapid progression of the coronavirus disease 2019 (COVID-19) pandemic, an ultrafast response was urgently required to handle this major public crisis. To contain the pandemic, investments are required to develop diagnostic tests, ...
Synthesis and In Silico Investigation of Isatin-Based Schiff Bases as Potential Inhibitors for Promising Targets against SARS-CoV-2 [0.03%]
基于吲哚芳乙酸类希夫碱的合成及其作为SARS-CoV-2潜在抑制剂的理论研究
Zohreh Esam,Malihe Akhavan,Maryam Lotfi et al.
Zohreh Esam et al.
Despite the significant development in vaccines and therapeutics cocktails, there is no specific treatment available for coronavirus disease 2019 (COVID-19), caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ta...
Alcohol-based Hand Sanitizers amid COVID-19: Chemical Formulation, Analysis, Safety [0.03%]
新冠肺炎疫情下的免洗手消毒剂：化学配方、分析及安全性的研究进展
Monarul Islam,Khondoker Shahin Ahmed,Rezaul Karim et al.
Monarul Islam et al.
Alcohol-based hand sanitizers (ABHSs) containing ethanol (EtOH) or isopropyl alcohol (IPA) to inactivate microorganisms help prevent the spread of respiratory diseases. These products have become very popular during the COVID-19 pandemic. A...
A Short Review Comparing Carbon-Based Electrochemical Platforms With Other Materials For Biosensing SARS-Cov-2 [0.03%]
基于碳的电化学平台与其他材料用于生物传感SARS-Cov-2的比较综述
Isha Soni,Pankaj Kumar,Gururaj Kudur Jayaprakash et al.
Isha Soni et al.
Due to the 2019 SARS-CoV-2 outbreak, low-cost, fast, and user-friendly diagnostic kits for biosensing SARS-CoV-2 in real samples employing multiple working electrodes are in high demand. Choosing SARS-CoV-2 detecting electrodes is difficult...