George N Pairas,Petros G Tsoungas
George N Pairas
H-bonding, as a non covalent stabilizing interaction of diverse nature, has a central role in the structure, function and dynamics of chemical and biological processes, pivotal to molecular recognition and eventually to drug design. Types o...
Semisynthesis and Biological Evaluation of Platensimycin Analogues with Varying Aminobenzoic Acids [0.03%]
具有不同氨基苯甲酸的platensimycin类似物的半合成和生物评价
Kai Tian,Youchao Deng,Lin Qiu et al.
Kai Tian et al.
Platensimycin (PTM) is an excellent natural product drug lead against various gram-positive pathogens, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. In this study, twenty PTM derivatives with va...
Identification and Screening of Selective WEE2 Inhibitors to Develop Non-Hormonal Contraceptives that Specifically Target Meiosis [0.03%]
识别和筛选选择性WEE2抑制剂以开发非激素类避孕药特异性靶向减数分裂
Carol B Hanna,Shan Yao,Mat Martin et al.
Carol B Hanna et al.
We used a progressive elimination strategy to identify oocyte-specific WEE2 kinase inhibitors for potential non-hormonal contraceptives that target meiosis. Beginning with an in-house library of over 300,000 compounds, virtual high throughp...
Antibacterial Properties of Charged TiN Surfaces for Dental Implant Application [0.03%]
用于牙科植入物的带电TiN表面的抗菌性能
Patrick H Carey th,Fan Ren,Ziqi Jia et al.
Patrick H Carey th et al.
The formation and characterization of positively surface charged TiN surfaces were investigated for improving dental implant survival. Surface nitrogen atoms of a traditional TiN implant were converted to a positive charge by a quaternizati...
Role of Anomalous Water Constraints in the Efficacy of Pharmaceuticals Probed by 1H Solid-State NMR [0.03%]
通过固态氢-1核磁共振研究药物有效性的异常水环境的作用
Joshua T Damron,Kortney M Kersten,Manoj Kumar Pandey et al.
Joshua T Damron et al.
Water plays a complex and central role in determining the structural and reactive properties in numerous chemical systems. In crystalline materials with structural water, the primary focus is often to relate hydrogen bonding motifs to funct...
Squaramide-Based 5'-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A [0.03%]
基于方胺酰胺的5'-磷酸根替代物与DNA修复外切核酸酶SNM1A结合
Eva-Maria Dürr,William Doherty,Sook Y Lee et al.
Eva-Maria Dürr et al.
Phosphate groups are often crucial to biological activity and interactions of oligonucleotides, but confer poor membrane permeability. In addition, the group's lability to enzymatic hydrolysis is an obstacle to its use in therapeutics and i...
Incorporation of Sensitive Ester and Chloropurine Groups into Oligodeoxynucleotides through Solid Phase Synthesis [0.03%]
通过固相合成将敏感的酯和氯嘌呤基团嵌入到寡核苷酸中
Bhaskar Halami,Shahien Shahsavari,Zack Nelson et al.
Bhaskar Halami et al.
Nucleosides containing ester groups that are sensitive to nucleophiles were incorporated into oligodeoxynucleotides (ODNs) through solid phase chemical synthesis. The sensitive esters are located on a purine nucleobase. They are the esters ...
Microwave-Assisted Biogenic Synthesis of Metal-Decorated Reduced Graphene Oxide and their Electrochemical Properties [0.03%]
微波辅助生物合成金属修饰的还原氧化石墨烯及其电化学性质
Krishna Prasad Gannavarapu,Samar Azizighannad,Sai Muthukumar V et al.
Krishna Prasad Gannavarapu et al.
Herein we report a microwave assisted, fungal (Ganoderma lucidum) extract mediated synthesis of noble metal decorated reduced graphene oxide(r-GO). The carbon to oxygen ratio increased from 1.46 in GO to 2.72 in r-GO. The electron rate tran...
Conformational Shift of a β-Hairpin Peptide upon Complex Formation with an Oligo-proline Peptide Studied by Mass Spectrometry [0.03%]
质谱研究与多脯氨酸肽形成复合物的β-发夹肽构象变化
Knut Kölbel,Stephan Warnke,Jongcheol Seo et al.
Knut Kölbel et al.
So-called super-secondary structures such as the β-hairpin, studied here, form an intermediate hierarchy between secondary and tertiary structures of proteins. Their sequence-derived 'pure' peptide backbone conformation is combined with 'r...
Charge-Neutral, Stable, Non-Cytotoxic, Near-Infrared SnS Aqueous Quantum Dots for High Signal-to-Noise-Ratio Biomedical Imaging [0.03%]
用于高信噪比生物医学 imaging的电中性、稳定、非细胞毒性近红外SnS水溶性量子点
Song Han,Wan Y Shih,Wei-Heng Shih
Song Han
We have synthesized charge-neutral, stable, non-cytotoxic, bright, near-infrared (NIR) SnS quantum dots (QDs) by first making Cysteamine-capped SnS QDs in glycerol under acidic conditions followed by lengthening the capping molecule with pe...