Development of a halofluorocarbon, chromatography-free radiosynthesis of fluorine-18 difluorocarbene [0.03%]
一种不含色谱的氟-18二氟卡宾放射性合成卤代氟烃的开发
Catherine G F Dickmann,Andrew D Bond,Selena Milicevic Sephton et al.
Catherine G F Dickmann et al.
Background: In recent years, the development of the [18F]difluoromethyl radical ([18F]2-((difluoromethyl)sulfonyl)benzo[d]thiazole, [18F]4), and [18F]difluorocarbene ([18F]1-chloro-4-((difluoromethyl)sulfonyl)benzene, [18...
Clemens Decristoforo,Renata Mikolajczak,Clive Naidoo et al.
Clemens Decristoforo et al.
Background: Radionuclides are the essential component of radiopharmaceuticals, their production needs to consider pharmaceutical regulations and guidelines, also for clinical research applications. ...
68Ga-radiolabeled fluorescent dye for potential non-invasive multimodal imaging of subarachnoid hemorrhage [0.03%]
一种潜在的非侵入性多模影像技术以68Ga放射标记荧光染料检测蛛网膜下腔出血
Jona Wilhelm Gerhards,Laura Schäfer,Daniel Kang et al.
Jona Wilhelm Gerhards et al.
Background: Aneurysmal subarachnoid hemorrhage (aSAH) is a distinct type of stroke, primarily caused by the rupture of a brain aneurysm. The underlying mechanisms of aSAH remain incompletely understood, prompting ongoing ...
Rapid cleavage of 6-[18F]fluoronicotinic acid prosthetic group governs BT12 glioblastoma xenograft uptake: implications for radiolabeling design of biomolecules [0.03%]
6-[(18)F]氟烟酸连接臂快速裂解主导BT12胶质母细胞瘤异种移植模型中的分布：分子影像剂标记设计的启示
Pyry Dillemuth,Abiodun Ayo,Xiaoqing Zhuang et al.
Pyry Dillemuth et al.
Background: Peptides radiolabeled with fluorine-18 are frequently synthesized using prosthetic groups. Among them, activated esters of 6-[18F]fluoronicotinic acid ([18F]FNA) have been prepared and successfully employed fo...
Development of new albumin-binding radiotracers for PET imaging of cerebrospinal fluid flow in the glymphatic system [0.03%]
用于甘马赫氏系统脑脊液流动的正电子发射断层扫描成像的新白蛋白结合放射性示踪剂的研发
Martta Peltoniemi,Surachet Imlimthan,Sonja C Jalonen et al.
Martta Peltoniemi et al.
Background: The glymphatic system is a recently discovered brain-wide clearance system that allows the cerebrospinal fluid (CSF) flow to clear metabolic waste, but the tools for the quantitative and non-invasive investiga...
Development of a CYP11B2 imaging tracer for primary aldosteronism: basic evaluation of iodine- and fluorine-incorporated pyridinyldihydroquinolinone derivatives [0.03%]
用于原发性醛固酮增多症的CYP11B2成像示踪剂的开发：碘和氟化的吡啶二氢异喹啉衍生物的基础评价
Yusuke Yagi,Hiroyuki Kimura,Riko Fuseda et al.
Yusuke Yagi et al.
Background: Current methods for diagnosing primary aldosteronism (PA) are limited by their invasiveness and diagnostic accuracy. This study aimed to develop nuclear medicine imaging tracers targeting CYP11B2, which is ove...
Exploring the radiochemistry of PARP inhibitors: a new era in therapy and imaging [0.03%]
PARP抑制剂的放射化学研究：治疗和影像的新时代
Gianluca Destro,Rebecca Rizzo,Chiara Rua et al.
Gianluca Destro et al.
Background: Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as a promising class of therapeutics, particularly in the treatment of cancers with defective DNA repair mechanisms, such as those with breast cancer...
Cancer in translation: cyanine carborane salts: a multifunctional theranostic approach to cancer treatment [0.03%]
癌症的治疗和诊断： Cyanine碳硼烷盐：癌症治疗的多功能诊疗方法
Simran Deep Kaur,Deepak N Kapoor
Simran Deep Kaur
Jarred Michael Scaffidi-Muta,Andrew David Abell
Jarred Michael Scaffidi-Muta
Background: The selective delivery of α-emitting radionuclides is emerging as a highly effective form of cancer therapy. With a short range and high cytotoxicity, α-particles can selectively kill cancerous cells whilst ...
Pyridyl-Ala in the third position of radiolabeled somatostatin antagonists: the effect of regioisomeric substitution [0.03%]
放射性标记生长抑素拮抗剂中第三位哌啶基-丙氨酸的异构体置换对其活性的影响研究
Rosalba Mansi,Natalie Bertarelli,Luigi Del Pozzo et al.
Rosalba Mansi et al.
Background: The radiolabeled somatostatin receptor subtype 2 (SST2) antagonists LM3 (Phe(4-Cl)1-c(DCys2-Tyr3-DAph(Cbm)4-Lys5-Thr6-Cys7)-DTyr8-NH2) and JR11 (Phe(4-Cl)1-c(DCys2-Aph(Hor)3-DAph(Cbm)4-Lys5-Thr6-Cys7)-DTyr8-NH...