Fully GMP-complient radiosynthesis of [161Tb]Tb-PSMA-1 using the miniAiO synthesizer for clinical translation [0.03%]
使用微型集成发生器进行[161Tb]Tb-PSMA-1符合GMP的全合成以实现临床转化
David Kryza,Pierre Le Fur,Jean Noël Badel et al.
David Kryza et al.
Background: Terbium‑161 (161Tb) is an emerging radionuclide for targeted radionuclide therapy that combines β⁻ emissions with short‑range conversion and Auger electrons, increasing its efficacy against micrometastatic...
Automated and manual synthesis of [68Ga]Ga-DOTA-4AH29 intended for PET-imaging of FAP-expression [0.03%]
自动化和手动合成[68Ga]Ga-DOTA-4AH29用于FAP表达的PET成像
Marion Berdal,Surasa Nagachinta,Ximena Langsberg et al.
Marion Berdal et al.
Background: Fibroblast activation protein is a well-established target for tumour imaging, and single-domain antibodies (sdAb) offer favourable pharmacokinetic properties for PET applications. However, the translation of ...
Preclinical evaluation of a fluorine-18-labeled indocyanine green analog for PET imaging of hepatic function [0.03%]
氟-18标记的类似物吲哚青绿用于肝功能正电子发射断层扫描成像的临床前评估
Khashayar Vakili,Alan Packard
Khashayar Vakili
Background: Accurate assessment of liver function and biliary excretion is a key aspect in the medical and surgical management of various liver conditions. Dynamic nuclear imaging techniques such as PET (positron emission...
Panitumumab labeled with Auger electron-emitting 197gHg/197mHg: cytotoxicity on human breast cancer cells and tumour and normal tissue uptake in mice with EGFR-overexpressing breast cancer xenografts [0.03%]
用Auger电子发射体197gHg/197mHg标记的帕尼单抗对人乳腺癌细胞和EGFR过度表达的移植性乳腺肿瘤及正常组织摄取的影响
Arthur C K Chu,Felix Ho,Conrad Chan et al.
Arthur C K Chu et al.
Background: 197gHg and 197mHg are attractive radionuclides for radioimmunotherapy of cancer due to their abundant Auger electron emissions (23.2 and 19.4 electrons/decay, respectively). Our aim was to study the cytotoxici...
Development and evaluation of improved in-house procedure for radiolabelling of theranostic agent [177Lu]Lu-PSMA-617 [0.03%]
一种用于[177Lu]Lu-PSMA-617的新型简便制备和评价方法及效果评估
Nino Jukić,Dražen Huić,Marijan Žuvić et al.
Nino Jukić et al.
Background: Recent focus in the treatment of prostate cancer is directed towards the development and application of theranostic agents such as [177Lu]Lu-PSMA-617. It combines a PSMA-specific peptidomimetic with a therapeu...
A comparative evaluation of chemical processes in anion exchange-based 62Zn/62Cu generator systems [0.03%]
基于阴离子交换的铜-锌同位素发生器体系的化学过程比较研究
Ferris L Bissen,Jose R Blanco,Elizabeth M Heidarisafa et al.
Ferris L Bissen et al.
Background: The interest in 62Cu as a tracer for positron emission tomography (PET) has motivated several designs of a 62Zn/62Cu radionuclide generator, the most common of which is based on anion exchange resin and a mixe...
Development of NOTA-based antibody-fragment labeling agent that reduces early renal radioactivity levels [0.03%]
一种基于NOTA的抗体片段标记剂的发展，可降低早期肾脏放射性水平
Shunsuke Katamoto,Hiroyuki Suzuki,Madoka Kobayashi et al.
Shunsuke Katamoto et al.
Background: Gallium-68 (68Ga) and copper-64 (64Cu) are radiometals used for nuclear medicine imaging and therapy. The compound 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) forms stable complexes with these radiomet...
Expanding 68Ga radiolabeling capacity: off-label use of PSMA-11 single vial cold kits through aliquoting and dual generator utilization [0.03%]
扩大68镓放射性标记能力：通过分装和双重发电机利用，PSMA-11单瓶非标签试剂盒的超范围使用
Olivier Perrin,Sarah Benkhoris,Johanne Vanney et al.
Olivier Perrin et al.
Background: Prostate cancer is a highly prevalent malignancy, and PET imaging targeting prostate-specific membrane antigen (PSMA) has become essential for assessing recurrence, metastatic spread and eligibility for radiol...
Design and development of a semi-automated solid target assembly for the indigenous production of medical radioisotopes in the PETrace-800 cyclotron [0.03%]
用于国产医用放射性同位素生产的PETrace-800回旋加速器半自动固体靶组装的设计与开发
Kanchan Kushwaha,Kavindra Pathak,Tejinder P Sabharwal et al.
Kanchan Kushwaha et al.
Background: Molecular imaging enables the non-invasive visualization of physiological processes at the cellular and molecular levels and is central to diagnostic nuclear medicine. Among clinically important theranostic ra...
Quality and pratical determinants in [99mTc]Tc-tetrofosmin preparation: hygrometry, syringe sorption & maximal activity per kit [0.03%]
99mTc-Tc-tetrofosmin的制备质量及其实用影响因素：湿度、注射器吸附性及每盒最大活度研究
Quentin Buon,Hugo Tep,Eli Bassi et al.
Quentin Buon et al.
Background: Tetrofosmin, labelled with technetium-99m ([99mTc]Tc-tetrofosmin), is a widely used radiopharmaceutical for myocardial perfusion imaging. Despite its routine use, several practical aspects of its preparation r...