Developing ether and alcohol based extraction chromatography resins for purification of antimony-119 in nuclear medicine [0.03%]
用于核医学中提取纯化119锑的醚和醇基萃取色谱树脂的开发
Aivija Grundmane,Illarion Dovhyi,Lauren Aburto-Kung et al.
Aivija Grundmane et al.
Production of 211At and automated radiosynthesis of [211At]MABG via electrophilic astatodesilylation [0.03%]
利用亲电子砹脱硅反应自动合成[211At]MABG及211At的生产
Yuto Kondo,Taiki Joho,Shigenori Sasaki et al.
Yuto Kondo et al.
Background: [211At]m-Astatobenzylguanidine ([211At]MABG) has demonstrated potent antitumor efficacy in preclinical models of malignant neuroendocrine tumours including neuroblastoma and pheochromocytoma/paraganglioma. The...
Preclinical evaluation of [68Ga]Ga-AAZTA-FAPI-46: a novel PET tracer for targeting fibroblast activation protein (FAP) [0.03%]
新型正电子发射断层扫描（PET）示踪剂[68Ga]Ga-AAZTA-FAPI-46：靶向成纤维细胞活化蛋白的临床前评估
Rebecca Rizzo,Paolo Rainone,Rachele Stefania et al.
Rebecca Rizzo et al.
Background: The aim of this work was to demonstrate the suitability of AAZTA chelator conjugated to a FAPI-46-derived FAP inhibitor and labelled with gallium-68 as a potential PET tracer. ...
RM2 and DB15 analogues bearing [177Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study [0.03%]
基于不同连接基的RM2和DB15类衍生物[177Lu]Lu-DOTAGA作为放射性治疗药物的对比研究
Panagiotis Kanellopoulos,Athanasios Bitzios,Ivan Zelepukin et al.
Panagiotis Kanellopoulos et al.
Background: Bombesin analogues are gaining popularity as GRPR-targeting theranostic agents aiming to provide molecular tools for a patient-tailored management. We previously reported on two series of DOTAGA-bearing GRPR-a...
Minimising the impact of stable 208Pb on recovery of 212Pb from a generator [0.03%]
减少稳定208Pb对从产生器回收212Pb的影响
Rachel Roberts,Tim Carthy,Jennifer Young et al.
Rachel Roberts et al.
Background: Stable 208Pb will accumulate over time in all 212Pb generators, forming an increasing proportion of the Pb atoms and potentially impacting the efficiency of chelation of 212Pb. This paper models the accumulati...
Optimization of a GMP-compliant automated one-pot synthesis of Al[18F]F-NOTA-Ubiquicidin29 - 41 for bacterial infection imaging by PET/CT [0.03%]
符合GMP的全自动一步合成Al[18F]F-NOTA-Ubiquicidin29-41优化用于细菌感染的PET/CT影像学检测
Anna Meyer,Thomas Ziegler,Jutta Moosbauer et al.
Anna Meyer et al.
Multifactorial analysis of radiochemical purity in high-activity 177Lu-labeled theranostics: impact of precursor source, 177Lu form, and production parameters [0.03%]
掺杂177Lu标记治疗诊断的影响因素分析：前体来源、177Lu形式和生产参数的影响
William Hunt,Mathew Long,Usama Kamil et al.
William Hunt et al.
Background: Lutetium-177 (177Lu) theranostics have revolutionized personalized cancer treatment, particularly with FDA-approved therapies like [177Lu]Lu-DOTA-TATE for neuroendocrine tumors and [177Lu]Lu-PSMA for prostate ...
Development and evaluation of a 99mTc-labeled olaparib analog for PARP imaging [0.03%]
一种用于PARP显像的放射性核素99mTc标记的Olaparib类似物的开发与评价
Wei Xu,Junjie Yan,Xinlin Zhong et al.
Wei Xu et al.
Background: Poly(ADP-ribose) polymerase (PARP) is an important therapeutic target in cancer treatment, and dynamic assessment of its expression level is essential for achieving precision therapy. Although 18F-labeled PARP...
Auger electron-emitting EGFR-targeted and non-targeted [197Hg]Hg-gold nanoparticles for treatment of glioblastoma multiforme (GBM) [0.03%]
用于治疗多形性胶质母细胞瘤（GBM）的奥格尔电子发射型表皮生长因子受体靶向及非靶向[197Hg]Hg-金纳米颗粒
Madeline K Brown,Zhongli Cai,Constantine J Georgiou et al.
Madeline K Brown et al.
Background: We describe here radiation nanomedicines for glioblastoma multiforme (GBM) composed of gold nanoparticles (AuNPs) that integrate the Auger electron-emitter, 197Hg. [197Hg]Hg-AuNPs were conjugated to anti-epide...
PET imaging of platelet derived growth factor receptor β in lung fibrosis [0.03%]
肺纤维化中血小板源性生长因子受体β的正电子发射断层扫描影像学研究
Olivia Wegrzyniak,Francesco Lechi,Johanna Rokka et al.
Olivia Wegrzyniak et al.
Background: Lung diseases such as idiopathic pulmonary fibrosis and acute respiratory distress syndrome (ARDS) are associated with significant morbidity and mortality, with limited treatment options. Platelet-derived grow...