Paving the way for future PSMA inhibitors: insights from comparative preclinical evaluations of structure modifications [0.03%]
构建未来PSMA抑制剂的途径：结构修饰比较药理研究的新见解
Katarína Hajduová,Kateřina Dvořáková Bendová,Miloš Petřík et al.
Katarína Hajduová et al.
Background: Prostate-specific membrane antigen (PSMA) is an established target for the imaging and treatment of prostate cancer. This study focused on the preclinical evaluation of three novel PSMA inhibitors-P15, P16, an...
[11C]HSP990 PET as a translational tool to investigate the role of Hsp90 in tumours and support the development of Hsp90 therapeutics [0.03%]
[pos-11C-HSP990]PET在肿瘤中的翻译研究工具及其支持Hsp90药物开发的作用
Romy Cools,Valeria Narykina,Koen Vermeulen et al.
Romy Cools et al.
Background: Hsp90 is a molecular chaperone that is often overexpressed across multiple cancer types and has a potential value as a prognostic marker as well as a therapeutic target. Given the high interest in Hsp90 therap...
Design and characterization of a novel prostate-specific membrane antigen-targeted radioligand modified with a fatty acid albumin binder for optimized circulation half-life [0.03%]
一种新型前列腺特异性膜抗原靶向放射配体的 design 与 characterization：采用脂肪酸白蛋白结合剂优化循环半衰期
Shaomei Zeng,Xiang Gao,Jiang Meng et al.
Shaomei Zeng et al.
Background: The March 2022 approval of [¹⁷⁷Lu]Lu-PSMA-617-the first targeted radioligand therapy (TRT) for metastatic castration-resistant prostate cancer (mCRPC)-addressed a critical need in therapeutic diagnostics. H...
Brain-penetrating peptide and antibody radioligands for proof-of-concept PET imaging of fibrin in Alzheimer's disease [0.03%]
用于阿尔茨海默病中证明概念的纤维蛋白正电子发射断层显像(PET)造影肽和抗体放射配体
Dag Sehlin,Ximena Aguilar,Marta Cortés-Canteli et al.
Dag Sehlin et al.
Background: Alzheimer's disease (AD) is increasingly recognized as a multifactorial disorder with vascular contributions, including a pro-coagulant state marked by fibrin deposition in the brain. Fibrin accumulation may e...
Sarandeep Kaur,Barbara Wenzel,Ramona Oehme et al.
Sarandeep Kaur et al.
Background: Copper-mediated radiofluorination (CMRF) is a breakthrough in 18F-radiochemistry, enabling 18F incorporation into molecules even at electron-rich aromatic positions. In recent years, several improved protocols...
Cytotoxicity of 212Pb-labeled anti-PTK7 antibody in 2D adherent and 3D multicellular bladder cancer models [0.03%]
标记抗PTK7抗体的212Pb的二维粘附和三维多细胞膀胱癌模型的细胞毒性作用
Kim Lindland,Asta Juzeniene
Kim Lindland
Background: Bladder cancer remains a significant global health challenge, with approximately 75% of cases presenting as non-muscle-invasive bladder cancer. Despite standard treatment with transurethral resection and intr...
Fibroblast activation protein expression in the tumor microenvironment is crucial in survival prediction and differentiation of recurrent gliomas: a head-to-head comparison of 68Ga-FAPI-04 and 18F-FET in PET/CT imaging [0.03%]
肿瘤微环境中的成纤维细胞活化蛋白表达在生存预测和复发胶质瘤分类中至关重要：68Ga-FAPI-04和18F-FET在PET/CT成像中的头对头比较
Tao Hua,Qi Huang,Zhirui Zhou et al.
Tao Hua et al.
Background: The precise differentiation of recurrent glioma from treatment-related changes, such as pseudoprogression or radiation necrosis, is essential for treatment planning and remains a significant challenge. Fibrobl...
Compact accelerator-based production of carrier-free 177Lu from 18 MeV [Formula: see text] on [176Yb] [Formula: see text] [0.03%]
基于紧凑型加速器的[Formula: see text][Formula: see text]轰击[176Yb]生产无载体镥-177的研究
Austin A Morris,Tianhao Wei,Zhi Wang et al.
Austin A Morris et al.
Background: Recent EMA and FDA approvals of Lu-DOTATATE and Lu-PSMA-617 have led to increased demand for radiotherapeutic 177 Lu, due to its promising potential to treat castration-resistant neuroendocrine cancers. Con...
Enhanced contrast in FAP-targeting PET imaging with 61Cu-labeled FAP inhibitors: development and preclinical evaluation of novel [61Cu]Cu-Kalios PET radioligands [0.03%]
新型[61Cu]Cu-Kalios PET放射配体的发展和临床前评估：开发用于FAP靶向PET成像的61Cu标记FAP抑制剂，以提高对比度
Jacopo Millul,Tais Basaco Bernabeu,Raghuvir H Gaonkar et al.
Jacopo Millul et al.
Background: Fibroblast activation protein (FAP)-targeting radioligands have gained attention for the ability to image multiple tumor types. Current FAP-targeting radioligands are labeled with 68Ga and 18F, but their short...
Side by side comparison of NOTA and DOTA for conjugation efficiency, gallium-68 labeling, and in vivo biodistribution of anti-mesothelin sdAb A1-His [0.03%]
一种抗间皮素sdAb A1-His的连接效率、68Ga标记及体内分布的NOTA与DOTA配体对比研究
Émilien N&#x;Guessan,Sandrine Bacot,Florian Raes et al.
Émilien N&#x;Guessan et al.
Background: Mesothelin is a glycoprotein overexpressed in various cancers, with limited expression in healthy tissues. The single-domain antibody (sdAb, or nanobody) A1-His has previously successfully been validated in mi...