Stability assessment of PET radiopharmaceuticals under extreme conditions: an ICH-compliant study on radiochemical and enantiomeric purity [0.03%]
符合ICH规范的极端条件下PET放射性药物稳定性评估：放射化学纯度和对映异构体纯度研究
Viktória Forgács,Lívia Vonza,Adrienn Fekete et al.
Viktória Forgács et al.
Background: The stability testing of radiopharmaceuticals is a critical aspect of drug development and regulatory approval. The International Conference on Harmonisation of Technical Requirements for Registration of Pharm...
Nonclinical investigations of a novel heart-type fatty acid-binding protein ligand, [18F]LUF: three-lot process validation, safety assessment, and radiation dosimetry [0.03%]
新型心型脂肪酸结合蛋白配体[18F]LUF非临床研究：三批次工艺验证、安全性评价及辐射剂量学研究
Jun Toyohara,Masahiko Ito,Muneyuki Sakata et al.
Jun Toyohara et al.
Background: Heart-type fatty acid-binding protein (FABP3) mediates the intracellular transport of fatty acids and is highly expressed in the myocardium. During myocardial infarction, FABP3 leaks from the myocardial cytopl...
Synthesis and in vitro characterization of [198Au]Auranofin [0.03%]
用于体外实验的[198Au]Auranofin合成及性质表征研究论文
Punita Bhardwaj,Caroline Frohner,Christopher Geppert et al.
Punita Bhardwaj et al.
Background: Radiopharmaceuticals offer targeted treatment by combining diagnostic or therapeutic radionuclides with biologically active molecules. Auranofin is the only Food and Drug Administration (FDA) approved gold(I) ...
Automated radiosynthesis of [18F]fluoromannitol for clinical research on a commercially available trasis allinone radiosynthesizer [0.03%]
在商用放射合成模块中全自动合成氟标记甘露醇（[18F]氟代甘露醇）用于临床研究
Amy L Vāvere,Allison J Clay,Arijit Ghosh et al.
Amy L Vāvere et al.
Background: Infections pose a significant risk to immunocompromised individuals, and accurate, efficient diagnosis remain challenging. Current imaging methods like MRI and FDG PET lack pathogen specificity which complicat...
[11C]Fentanyl: radiosynthesis and preclinical pet imaging for its pharmacokinetics [0.03%]
[11C]肤宁诺啡的放射合成及其药代动力学的PET显影研究
Woochan Kim,Aaron K Wozniak,Nathaniel J Burkard et al.
Woochan Kim et al.
Background: Fentanyl is a potent synthetic opioid widely used for pain management and anesthesia, but the high prevalence of its misuse and its key contribution to overdose fatalities in the United States have made it a m...
Establishment and validation of an alternative automated synthesis of [68Ga]Ga-DOTA-Siglec-9 in an independent laboratory for clinical use [0.03%]
在独立实验室中建立并验证[⁶⁸Ga]Ga-DOTA-Siglec-9自动化合成方法以供临床使用
Silvia Migliari,Alessandra Guercio,Anna Gagliardi et al.
Silvia Migliari et al.
Background: Siglec-9, a member of the Siglec family of receptors, plays a crucial role in modulating immune cell trafficking and inflammation, with significant clinical implications. It is predominantly expressed on immun...
Quantitative dual-isotope preclinical SPECT/CT imaging and biodistribution of the mercury-197m/g theranostic pair with [197m/gHg]HgCl2 and a [197m/gHg]Hg-tetrathiol complex as a platform for radiopharmaceutical development [0.03%]
一种新的放射性配体[197m,gHg]HgCl2和[197m,gHg]Hg-四硫醇复合物的体内成像及生物分布研究：用于放射药物开发的靶向诊断与治疗对（197m/gHg）
Parmissa Randhawa,Cristina Rodríguez-Rodríguez,Helena Koniar et al.
Parmissa Randhawa et al.
Background: Mercury-197m (197mHg, t1/2 = 23.8 h) and mercury-197g (197gHg, t1/2 = 64.14 h) possess favorable nuclear properties for imaging and targeted therapy, but the development of suitable chelators for mercury-based...
PET imaging of mitochondrial complex-I in the adenine-induced tubulointerstitial nephropathy mouse model using [18F]BCPP-BF [0.03%]
采用[18F]BCPP-BF正电子发射断层成像法研究腺嘌呤诱导的肾小管间质性肾病小鼠模型中线粒体复合物I的功能
Kenneth Dahl,Peter Johnström,Miklós Toth et al.
Kenneth Dahl et al.
Background: Chronic kidney disease (CKD) poses a significant global health burden with limited effective treatments for its prevention, progression, and associated complications. Mitochondrial dysfunction is recognized as...
Highlight selection of radiochemistry and radiopharmacy developments by editorial board [0.03%]
编辑部精选的放射化学和放射药学进展 highlights
Jun Toyohara,Philipp H Elsinga,Sergio Todde et al.
Jun Toyohara et al.
Background: The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field of radiopharmaceutical development and application of radiopha...
Potentials and practical challenges of terbium-161 labeled radiopharmaceuticals [0.03%]
161铥标记放射性药物的潜力及实际挑战
Carolline M Ntihabose,Maryana Handula,Amber Piet et al.
Carolline M Ntihabose et al.
Background: Due to promising preclinical studies and clinical case reports, Tb-161 labeled radiopharmaceuticals for targeted radionuclide therapy (TRT) have gained interest. Unlike Lu-177, Tb-161 not only emits β- partic...