cGMP-compliant high-yield automated production of [18F]AlF-FAPI-74: optimization of quality control and evaluation of molar dose impact [0.03%]
符合cGMP的高产自动化生产[18F]AlF-FAPI-74：优化质量控制和评估摩尔剂量影响
Ward Storms,Sofie Celen,Justine Maes et al.
Ward Storms et al.
Background: Fibroblast activation protein inhibitor (FAPI)-based positron emission tomography (PET) radiopharmaceuticals have shown promise for imaging cancer-associated fibroblasts (CAFs), a key component of the tumor mi...
PDGFRß targeted positron emission tomography as a non-invasive biomarker for activated hepatic stellate cells: lasts steps before clinical translation [0.03%]
PDGFRß靶向正电子发射断层扫描作为活化肝星状细胞无创生物标志物：临床转化前的最后步骤
Chittampalli N Yashaswini,Bogdan Mitran,Natalia Papadopoulos et al.
Chittampalli N Yashaswini et al.
Establishing Pb-203 production from electrodeposited Tl targets at Brookhaven National Laboratory [0.03%]
在布鲁克海文国家实验室用电沉积铊靶建立Pb-203生产体系
Wilson Lin,Dmitri G Medvedev,Cathy S Cutler et al.
Wilson Lin et al.
Background: Promising developments in Pb-212 radiopharmaceutical therapies have increased demand for Pb-203 diagnostic agents. Building on previous work from various isotope production facilities, this study optimized Pb-...
Aluminum-[18F]fluoride radiolabeling of triarylphosphines for cell labeling via the perfluoroaryl azide Staudinger ligation [0.03%]
通过全氟芳基叠氮化合物与亚磷酸三芳基酯的Staudinger连接反应对细胞进行[18F]氟化铝放射性标记的新方法研究
Anisa Biti,Surachet Imlimthan,Heidi Harjunpää et al.
Anisa Biti et al.
Background: The development of safer and more effective cell-based therapies requires robust methods for tracking cells in vivo. Positron emission tomography (PET) is a highly sensitive nuclear imaging technique capable o...
Evaluating methodological constraints in PET imaging of neuropeptide Y2 receptors with N-[11C]-methyl-(R)-JNJ-31020028 in brains of C57BL/6J mice [0.03%]
评价PET成像技术在小鼠脑内神经肽Y2受体显影剂N-[11C]甲基-(R)-JNJ-31020028的方法学限制
Karsten Bamminger,Eduardo Felipe Alves Fernandes,Lena Zachhuber et al.
Karsten Bamminger et al.
Background: The Neuropeptide Y (NPY) system regulates mood, stress, and feeding behavior and plays a central role in neuropsychiatric and metabolic disorders. It exerts its effects primarily through a family of G-protein-...
Synthesis and preclinical evaluation of FAP-targeting radiotracers for PET and optical imaging [0.03%]
用于PET和光学成像的FAP靶向放射性示踪剂的合成与临床前评估
Jürgen Kogler,Cornelius K Donat,Johanna Trommer et al.
Jürgen Kogler et al.
Background: Successful treatment of solid cancers relies on precise diagnosis, e.g. using noninvasive molecular imaging, followed by surgical removal and/or chemo/immunotherapy. Despite advances in pre-operative imaging, ...
Assessing the radiation-induced bystander effect in radionuclide therapy using targeted radiopharmaceuticals [0.03%]
靶向放射性药物介导的辐射诱发旁观者效应的评估
Rohit Sharma,Archana Mukherjee,Poonam Jagasia et al.
Rohit Sharma et al.
Background: Radiation-induced biologic bystander effects (RIBBEs) where non-irradiated cells display radiation like responses are well established in the context of external beam radiotherapy. However, their presence and ...
Extending the shelf life of ⁶⁸Ge/⁶⁸Ga generators via preconcentration of [⁶⁸Ga]GaCl₃ for preclinical application [0.03%]
一种用于临床前应用的68Ga/GaCl3发生器的保质期延长方法
Hemantha Mallapura,Olof Eriksson
Hemantha Mallapura
Background: ⁶⁸Ga-labeled tracers are increasingly important for PET imaging and as companion diagnostics with new therapeutic radiopharmaceuticals. The ⁶⁸Ge/⁶⁸Ga generator is a common source for clinical and preclin...
Optimization of the radiosynthesis of the PSMA-targeting drugs [177Lu]Lu-P17-087 and [177Lu]Lu-P17-088 on the MiniLu™ automated module [0.03%]
基于MiniLuTM自动模块的PSMA靶向药物[177Lu]Lu-P17-087和[177Lu]Lu-P17-088放射合成的优化
David Alexoff,Karl Ploessl,Ruiyue Zhao et al.
David Alexoff et al.
Background: There is a renewed interest in radioligand therapy for cancer treatment since the approval of Lu-177 vipivotide tetraxetan (PSMA-617) by regulators in Europe and the United States for metastatic castrate resis...
Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution [0.03%]
用于放射治疗诊断应用的GRPR靶向肽的改进：来自配体修饰和α-甲基-L色氨酸替代的见解
Karim Obeid,Ekaterina Bezverkhniaia,Vladimir Tolmachev et al.
Karim Obeid et al.
Background: Targeting the gastrin-releasing peptide receptor (GRPR) is a promising approach for radionuclide therapy in prostate and breast cancers. GRPR-targeting peptides often have limited metabolic stability, which ca...