Fluorine-18-labeled PET radiotracers for imaging the macrophage colony-stimulating factor 1 receptor (CSF1R) [0.03%]
用于正电子发射断层显影剂成像的氟-18标记放射示踪剂(macrophage colony刺激因子1受体(CSF1R))
Deepankar Das,Hyojin Cha,Ravi Naik et al.
Deepankar Das et al.
Background: Positron emission tomography is a useful tool for quantitative imaging of neuroinflammation in human subjects; however, more suitable radiotracers are sought. One of the promising targets for imaging neuroinfl...
191Pt-labeled trithiol-Hoechst-PSMA: preliminary evaluation of conjugates designed for delivery to genomic DNA of PSMA-positive cancers [0.03%]
191铂标记的三硫醇- Hoechst - PSA：设计用于向PSMA阳性癌症的基因组DNA传递的缀合物的初步评估
Honoka Obata,Atsushi B Tsuji,Yutian Feng et al.
Honoka Obata et al.
Background: Several platinum radionuclides, including 191Pt, are promising candidates for DNA-targeted Auger electron radiotherapy; however, effective compound designs are needed for this application. In this study, we de...
Liquid chromatographic determination of enantiomeric purity of [11C]methyl-L-methionine and O-(2-[18F]fluoroethyl)-L-tyrosine by pre-column derivatization with o-phthaldialdehyde and N-isobutyryl-L-cysteine [0.03%]
柱前衍生化法测定[11C]甲基-l-蛋氨酸和O-(2-[18F]氟乙基)-L-酪氨酸旋光异构体纯度的液相色谱法
Viktória Forgács,Viktória Balla,Viktória Csonka et al.
Viktória Forgács et al.
Background: [11C]methyl-L-methionine ([11C]MET) and O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) are commonly used radiopharmaceuticals in positron emission tomography (PET) for diagnosis of brain tumors. The preparations...
Assessment of quality control and effect of radiolysis on the in vivo biodistribution of [177Lu]Lu-PSMA-I&T [0.03%]
质量控制评估及辐射分解对[177Lu]Lu-PSMA-I&T体内分布的影响研究
Eline L Hooijman,Carolline M Ntihabose,Stijn L W Koolen et al.
Eline L Hooijman et al.
Background: One of the challenges in optimizing PSMA-based therapies for the treatment of prostate cancer is the stability of the radiopharmaceutical, defined by the degradation of radiolabeled compounds due to exposure t...
Feasibility of albumin binding modulation in FAP-targeting radiopharmaceuticals: insights from molecular docking and experimental analysis [0.03%]
基于分子对接和实验分析的FAP靶向放射性药物的白蛋白结合调节可行性研究
Sudabeh Shokrollahi,Ahmad Amiri
Sudabeh Shokrollahi
Background: Understanding the interaction between radiopharmaceuticals and human serum albumin (HSA) is essential for optimizing pharmacokinetics and therapeutic efficacy. This study evaluated the binding properties of na...
Developing a theranostic nanobody targeting FAP for cancer imaging and therapy [0.03%]
一种用于癌症成像和治疗的靶向FAP的诊疗纳米抗体的研发
Lital Ben-Naim,Suma Prabhu,Miguel Ferreira et al.
Lital Ben-Naim et al.
Background: Fibroblast activation protein (FAP) is a pan-cancer target. Its selective expression on the majority of solid tumors with minimal to absent expression in healthy tissues positions FAP as a promising target for...
Scale-up production of [211At]PSMA-5 using automated synthesizer for Investigator-Initiated clinical trial [0.03%]
使用自动化合成器进行[211At]PSMA-5大规模生产以开展探究者发起的临床试验
Sadahiro Naka,Tadashi Watabe,Yoshifumi Shirakami et al.
Sadahiro Naka et al.
Background: [211At]PSMA-5 is a novel α-emitting therapeutic agent designed to target prostate-specific membrane antigen (PSMA), which is overexpressed in metastatic castration-resistant prostate cancer (mCRPC). Unlike β...
Unambiguous analytical separation and improved syntheses of [11C]acetate and [11C]acetoacetate [0.03%]
明确的分析分离及[11C]乙酸和[11C]乙酰乙酸改进合成法
Karsten Bamminger,Lukas Nics,Marcus Hacker et al.
Karsten Bamminger et al.
Background: [11C]Acetate and [11C]acetoacetate are PET radiotracers widely used to assess oxidative metabolism and ketone body utilization, respectively. This study aimed to establish robust, high-yield syntheses of both ...
Preclinical characterization of 3p-C-DEPA-NCS and 3p-C-DEPA-TFP-PEG4 as potential Actinium-225 bifunctional chelators using DOTA-NCS and macropa-NCS as benchmarks [0.03%]
以DOTA-NCS和macropa-NCS为基准的潜在的用于Actinium-225的双功能螯合剂3p-C-DEPA-NCS和3p-C-DEPA-TFP-PEG4的药物非临床特征化研究
Jessica Pougoue Ketchemen,Stephen Ahenkorah,Emmanuel Nwangele et al.
Jessica Pougoue Ketchemen et al.
Background: Actinium-225 (225Ac) based targeted alpha therapies (TAT) have emerged as a promising strategy for the treatment of several cancer types due to its favourable decay properties, including high linear energy tra...
Development of a radio thin-layer chromatography scanner: Design and qualification [0.03%]
无线电薄层色谱扫描仪的开发：设计与定型
Tomás Chivato Martín-Falquina,Elena Miñana Olmo,Ángela Alonso García et al.
Tomás Chivato Martín-Falquina et al.
Background: Radiochemical Purity (RCP) assessment is a fundamental quality control parameter in radiopharmaceutical production. Thin-Layer Chromatography (TLC) using a radio-TLC scanner is the most common method employed ...