Lung perfusion imaging in nuclear medicine with 99mTc: a comprehensive survey of radiopharmaceuticals [0.03%]
核医学中用于肺灌注显像的99mTc放射性药物的全面综述
Hassan Zareian,Mehrnaz Mardazad,Mahshid Kiani et al.
Hassan Zareian et al.
Background: Technetium-99 m-labeled macroaggregated albumin ([⁹⁹ᵐTc]Tc-MAA) is the standard agent for lung perfusion imaging in pulmonary embolism (PE). Limitations related to particle consistency, preparation procedur...
Preliminary biological evaluation of a [177Lu]Lu-labeled peptide targeting Nectin-4 [0.03%]
一种针对Nectin-4的[177Lu]Lu标记肽的初步生物评价
Dengke Li,Yu Zhang,Chao Mu et al.
Dengke Li et al.
Background: Despite the clinical implementation of Nectin-4-targeted antibody-drug conjugates (ADCs) and radioligand therapies (RLTs), their therapeutic window is often restricted by systemic toxicities and the emergence ...
Highlight selection of radiochemistry and radiopharmacy developments by editorial board [0.03%]
编辑部精选的放射化学和放射药学进展摘要
Oliver C Kiss,Ivan Penuelas,Ana Rey et al.
Oliver C Kiss et al.
Background: The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field of radiopharmaceutical development and application of radiopha...
An improved fully-automated GMP radiosynthesis of [18F]fluoro-pivalic acid with solid-phase extraction purification [0.03%]
一种改进的用于制备[18F]氟代戊酸的全自动化GMP放射合成法及固相萃取纯化法
Chris Barnes,Frazer Twyman,Ramla O Awais et al.
Chris Barnes et al.
Background: We previously reported the first-in-human evaluation of 3-[18F]-fluoro-2,2-dimethylpropionic acid ([18F]FPIA) for imaging aberrant lipid metabolism and cancer detection. The first-generation semi-automated rad...
Increased affinity by dimerization of radiolabeled Affibody molecule ATH001 targeting PDGFRβ [0.03%]
通过二聚体化提高放射性标记的ATH001（Affibody分子）与PDGFRβ结合的亲和力
Ayman Abouzayed,Hugo Olsson,Natalia Papadopoulos et al.
Ayman Abouzayed et al.
Background: Platelet-derived growth factor receptor-β (PDGFRβ) is a canonical marker of pericytes and stromal cells in most tissues. It is present on cancer associated fibroblasts (CAFs) in the tumor microenvironment an...
The 68Ge/68Ga generator for enhancing productivity and reducing costs in nuclear medicine: experience from a university hospital [0.03%]
用于提高核医学生产力和降低成本的锗-68/镓-68发生器：一家大学医院的经验
Alessandra Guercio,Tess Martin,Silvia Migliari et al.
Alessandra Guercio et al.
Background: Sustainability in healthcare, particularly Nuclear Medicine, is essential, especially in managing radioactive materials. Traditional centralized production of Fluorine-18 tracers for PET imaging faces challeng...
Automated radiosynthesis of 2-[18F]BPA for PET-based planning of boron neutron capture therapy (BNCT): rational precursor design, radiofluorination, and characterization of methodology [0.03%]
自动化合成放射性氟-18标记的2-[18F]BPA用于基于正电子发射断层成像的硼中子俘获治疗计划：合理的前体设计，放射性氟化和方法学表征
Vincenzo Paolillo,Cong-Dat Pham,Robert Ta et al.
Vincenzo Paolillo et al.
Background: Boron neutron capture therapy relies on the selective accumulation of boron-containing compounds in tumor tissue, making accurate quantification of boron distribution essential for effective treatment planning...
Co-57-based intercomparison of TLC scanners and dose calibrators for low-activity radiochemical purity assessment in radiopharmaceutical quality control [0.03%]
基于Co-57的薄层色谱仪和放射性活度计的比对研究在放射性药物质量控制中的低水平放化纯评价中的应用研究
Marietta Straub,Michel Leresche,Claude Pilloud et al.
Marietta Straub et al.
Background: Thin layer chromatography scanners and dose calibrators are commonly used to assess radiochemical purity of radiopharmaceutical preparations. Strict quality assurance programs surveyed by regulatory bodies exi...
Long-term performance evaluation of a novel 3.26 GBq 68Ge/68Ga generator [0.03%]
一种新型3.26 GBq 68Ge/68Ga发生器的长期性能评估
Xiaoyang Hu,Renxin Hu,Yao Yang et al.
Xiaoyang Hu et al.
Background: 68Ga is a key radionuclide in PET due to its favorable decay properties, generator availability, and growing preclinical and clinical use of 68Ga-labeled radiopharmaceuticals. The performance of the 68Ge/68Ga ...
Ensuring enantiomeric consistency in FAPI radiopharmaceuticals: comparative analysis of (S)- and (S/R)-FAPI-46/-74 confirms pharmacological equivalence [0.03%]
确保FAPI放射性药物的对映面一致性：(S)-和(S/R)-FAPI-46/-74的比较分析证实了其药理等效性
Magdalena Staniszewska,Ralph Hübner,Camilla Locatelli et al.
Magdalena Staniszewska et al.
Background: Enantiomeric composition may impact binding and potentially performance of a drug product but is not routinely tested and minimum acceptance criteria are not always established. Some batches of the precursors ...