Structure-activity relationship of 18F-labeled PD-L1-targeting small molecule ligands: impact of radiolabeling strategy on affinity and in vivo performance [0.03%]
18F标记PD-L1靶向的小分子配体的构效关系：放射性标记策略对亲和力及体内性能的影响
Fabian Krutzek,Cornelius K Donat,Sven Stadlbauer
Fabian Krutzek
Background: Immune checkpoint inhibitor therapy addressing the PD-1/PD-L1 axis is a promising approach in cancer treatment. A clinically suitable radiotracer would allow molecular imaging of the temporospatial changes in ...
Protein-based Radiopharmaceuticals that target fibroblast activation protein alpha: a review of current progress [0.03%]
基于蛋白质的放射性药物靶向成纤维细胞活化蛋白α的研究进展综述
Abdelrahman Homedan,Darpan N Pandya,Nicholas J Schnicker et al.
Abdelrahman Homedan et al.
Background: Fibroblast activation protein alpha (FAP) is a serine protease that is expressed at basal levels in benign tissues but is overexpressed in a variety of pathologies, including cancer. Consequently, significant ...
It's a match: use of the radionuclide theranostic pair 133La/225Ac for the radiopharmacological characterization of EGFR-targeted single-domain antibodies [0.03%]
配体匹配：放射示踪药对133La/225Ac用于表皮生长因子受体靶向单域抗体的放射药理学性质研究
Johanna Trommer,Martin Ullrich,Falco Reissig et al.
Johanna Trommer et al.
Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET [0.03%]
一种用于体内检测难辨梭菌感染的毒株特异性免疫示踪剂的开发免疫PET）
Mario González-Arjona,Lorena Cussó,Luis Alcalá et al.
Mario González-Arjona et al.
Background: Clostridioides difficile infection (CDI) is a major healthcare challenge that is associated with high morbidity and mortality. Current diagnostic methods are limited in terms of specificity and invasiveness, n...
[90Y]Y-L4-Lipo/ ethyl esters of Iodized fatty acids of poppy seed oil (lipiodol® ultra-fluid), a new TARE formulation, designed from a lipophilic ligand for stability and safety [0.03%]
[90Y]Y-L4-脂洛特油（碘化罂粟籽油乙酯，Lipiodol Ultra Fluid）一种新型靶向放射性核素治疗偶联物的设计及稳定性研究
Olivier Fougère,Anne Dencausse,Nicolas Lepareur et al.
Olivier Fougère et al.
Background: Despite recent therapeutic advances, managing liver cancer remains a significant medical and economic priority for many countries. Patients often present at an advanced stage, preventing them from benefiting f...
Correction: Highlight selection of radiochemistry and radiopharmacy developments by editorial board [0.03%]
更正：编辑部选择放射化学和放射药学发展要点
S Spreckelmeyer,J Dasilva,C Decristoforo et al.
S Spreckelmeyer et al.
Published Erratum
EJNMMI radiopharmacy and chemistry. 2025 Jun 2;10(1):28. DOI:10.1186/s41181-025-00351-w 2025
Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression [0.03%]
选择最佳配体标记DARPin Ec1以进行68Ga-PET成像检测EpCAM表达水平
Anzhelika Vorobyeva,Moeen-Ud Din,Alexey Schulga et al.
Anzhelika Vorobyeva et al.
Background: Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein, which is overexpressed in several types of malignancies. Designed ankyrin repeat protein (DARPin) Ec1 is a 19 kDa engineered scaffold ...
D-Glucose and its derivatives labeled with radioactive carbon and hydrogen: key tools for investigating biological processes and molecular mechanisms [0.03%]
放射性碳氢标记的D-葡萄糖及其衍生物——探究生命过程和分子机制的重要工具
Fahimeh Bayat
Fahimeh Bayat
Background: Radiolabeling is a technique that involves attaching radioactive isotopes to molecules, allowing for their tracking and analysis in biological systems. Radiolabeled D-glucose and its derivatives have a very pr...
Preparation and preclinical evaluation of 18F-labeled folate-RGD peptide conjugate for PET imaging of triple-negative breast carcinoma [0.03%]
用于三阴性乳腺癌PET影像的18F标记叶酸-RGD肽偶联物的制备及临床前评价研究
Subhani M Okarvi,Yousef Maliki
Subhani M Okarvi
Background: Simultaneous targeting of RGD and FA receptors on breast carcinoma could improve the diagnostic outcome of breast cancer patients. In this study, we have designed and synthesized an FA-RGD heteromeric targetin...
Toxicity study of TEoS-DAZA, a chemical precursor for functional liver imaging with PET/CT [0.03%]
用于PET/CT功能肝影像的前体化合物TEoS-DAZA的毒性研究
Julia Greiser,Beatrice Engert,Roman Föll et al.
Julia Greiser et al.
Background: N,1,4-Tri(4-ethoxy-2-hydroxybenzyl)-1,4-diazepan-6-amine (TEoS-DAZA), a novel radiopharmaceutical precursor for a liver-specific 68Ga-based diagnostic radiopharmaceutical, was tested for toxicity in rats to en...