Rim Malek,Madeleine Landry,Pierre Cheung et al.
Rim Malek et al.
Background: Mucin 1 (MUC1) is a transmembrane glycoprotein overexpressed and underglycosylated in numerous epithelial cancers, including breast cancer. Reduced glycosylation leads to the exposure of the variable number ta...
Radiation stability and performance of TEHDGA resin for theranostic scandium radionuclide purification [0.03%]
用于诊疗同位素纯化的TEHDGA树脂的辐照稳定性和性能
Rudolfs Janis Zabolockis,Edgars Mamis,Laura Dace Pakalniete et al.
Rudolfs Janis Zabolockis et al.
Background: Scandium radionuclides are emerging theranostic radionuclides that offer matched diagnostic and therapeutic emissions for targeted applications in nuclear medicine. For their safe and effective clinical use, i...
Radionuclide-based pharmaceuticals for breast cancer imaging: state of the art [0.03%]
乳腺癌放射性药物影像剂的现状
P Paraïso,C H M van Deurzen,Y Seimbille
P Paraïso
Background: Breast cancer (BC) is a biologically heterogeneous disease, and no single imaging modality captures the full spectrum of phenotypes across all stages of the disease. This review summarizes advances in receptor...
Optimization of automated radiosynthesis method for [18F]AlF-NOTA-Octreotide and PET/CT imaging in neuroendocrine neoplasms [0.03%]
优化自动化的[18F]AlF-NOTA-Octreotide放射合成方法及神经内分泌肿瘤的PET/CT显影研究
Xiaoting Wan,Jiangyue Yan,Jieting Hu et al.
Xiaoting Wan et al.
Background: Neuroendocrine neoplasms (NENs) represent heterogeneous tumors with increasing occurrence rate. Somatostatin receptor (SSTR) imaging using 68Ga-labeled analogs is crucial but limited by the relatively short ha...
Clinical nuclear medicine applications of zirconium-89 immuno-PET: a comprehensive review from a radiopharmaceutical perspective [0.03%]
放射药学视角下的89Zr免疫PET临床应用：全面综述
Julien Dubois,Emmanuel Deshayes,Florentin Kucharczak et al.
Julien Dubois et al.
Background: Immuno-positron emission tomography (immuno-PET) imaging is emerging as a highly promising technique for the non-invasive diagnosis of a wide range of pathological conditions, particularly in oncology and immu...
A 3D co-culture model with fibroblast-restricted FAP expression for cancer therapy using [212Pb]Pb-FAPI-46 [0.03%]
一种用于癌症治疗的三维共培养模型，使用[212Pb]Pb-FAPI-46和成纤维细胞限制性FAP表达
Sandra K Kristiansen,Nurtene Dernjani,Øyvind S Bruland et al.
Sandra K Kristiansen et al.
Radiolabeling efficiency of FENTA chelators and stability of their terbium-161, lutetium-177 and bismuth-213 complexes [0.03%]
FENTA螯合物的放射标记效率及其镝-161、镥-177和铋-213复合物的稳定性
Cédric Bonneux,Sunay Rodríguez Pérez,Stephan Heinitz et al.
Cédric Bonneux et al.
Background: Phenanthroline derivatives are well-known chelators in coordination chemistry, but their potential in the rapidly evolving field of targeted radionuclide therapy (TRT) has not yet been explored. In TRT, DOTA r...
Comparison of two 18F-fluorinated glycopeptides for PET imaging of the functional liver mass [0.03%]
两种以18F标记的糖肽甘露醇化合物用于正电子发射断层扫描技术进行肝功能成像的比较研究
Maximilian A Zierke,Katharina Hofer,Kimia Samadikhah et al.
Maximilian A Zierke et al.
Background: The non-invasive determination of the asialoglycoprotein receptor (ASGR) expression on liver tissue might be a predictive parameter helping to prevent severe liver diseases as well as liver failure after surge...
The use of mass cytometry (CyTOF) to evaluate the cellular uptake of stable radiopharmaceutical surrogates in single cells: a proof-of-concept study [0.03%]
应用高参数质谱流式细胞术评价稳定型放射性药物类似物在单个细胞水平摄取的原理证实研究
Miguel Gómez-Sánchez,Elisa Blanco-González,María Montes-Bayón et al.
Miguel Gómez-Sánchez et al.
Background: Current methods for assessing radiopharmaceutical uptake are based on scintillation counting (e.g., γ-counting) or imaging techniques, such as positron emission tomography (PET) and single photon emission com...
Redox-driven speciation and colloid formation contribute the in vivo chemistry and organ deposition of Astatine-211 [0.03%]
红氧化学转化、物种形成及胶体作用对砹-211在 vivo 化学性质及器官分布的影响
Xiaoxu Dong,Jiaojiao Li,Mumei Chen et al.
Xiaoxu Dong et al.
Background: Astatine-211 (211At) is a promising radionuclide for targeted alpha therapy (TAT), yet its clinical translation is hindered by poor in vivo stability and pronounced non-target organ accumulation. The fundament...