Drying stability and permeability advantages of amorphous drug nanoparticles [0.03%]
无定形药物纳米粒的干燥稳定性及渗透优势研究
Akshay Narula,Ajay Lale,Paroma Chakravarty et al.
Akshay Narula et al.
The objective of this study was to develop stable amorphous drug nanoparticles with high drug loading and bioavailability advantages to overcome the drug-loading limitations of conventional amorphous solid dispersion (ASD) formulations. Amo...
Mechanistic models with experimental comparison for microwave-assisted lyophilization in a vial [0.03%]
带实验对比的用于瓶中微波辅助冷冻干燥的机理模型
Isaac S Wheeler,Ahmad Darwish,Vivek Narsimhan et al.
Isaac S Wheeler et al.
Microwave heating has been shown to accelerate pharmaceutical lyophilization but robust process models, crucial to ensuring that the process is efficient without damaging products, are still scarce. Building on both high-frequency microwave...
Machine learning guided optimization of an oral microemulsion system: a Bayesian optimization approach [0.03%]
基于贝叶斯优化的口服微乳体系的机器学习指导优化方法研究
Madeline Gunawardena,Bao Chau,Hayden Nothacker et al.
Madeline Gunawardena et al.
Oral microemulsions are one drug delivery system often implemented to improve intestinal permeability and oral bioavailability of poorly water-soluble drugs. They also present several practical advantages including high patient compliance a...
Real-time in vivo tracking of nanoparticulate vaccines in inguinal lymph nodes [0.03%]
实时监测纳米颗粒疫苗在腹股沟淋巴结内的分布和行为研究
Bishal Misra,Kaitlyn M Landreth,William H Pentz et al.
Bishal Misra et al.
Understanding the kinetics of nanoparticle vaccine drainage to the lymph nodes and their residence time in these tissues is critical in vaccine development. Evaluating these parameters using conventional techniques is expensive, time-consum...
Mastering particle size analysis: lessons, challenges, and future directions from the FDA-CRCG workshop [0.03%]
粒径分析的挑战与未来方向——FDA-CRCG研讨会经验教训杂谈
Xiaoming Xu,William C Smith,James E Polli et al.
Xiaoming Xu et al.
Particle-size distribution (PSD) measurement is a cornerstone of pharmaceutical development and regulatory assessment, influencing formulation stability, dissolution, product quality, and performance. Yet the seemingly straightforward natur...
Recent trends in pharmaceutical freeze-drying and control strategies observed in human drug applications and manufacturing inspections [0.03%]
近年来的人用药品申报与生产监管过程中观察到的冻干制剂新趋势及控制策略
Steve Y Rhieu,Maxwell Korang-Yeboah,David D Anderson et al.
Steve Y Rhieu et al.
Freeze-drying has been a workhorse for the pharmaceutical industry to enable long-term storage and long-distance transport of drug products that are unstable in liquid or frozen form. The importance of freeze-drying was particularly evident...
Investigating the impact of charge and hydrophilicity on peptide-mucin interactions using a simple mucin model [0.03%]
利用简单的粘蛋白模型研究电荷和亲水性对肽-粘蛋白相互作用的影响
Waleed M Elballa,Aiden Gregory,Teruna J Siahaan et al.
Waleed M Elballa et al.
In vitro models used to investigate drug diffusion face certain limitations and challenges because they omit for mucus interactions that could influence diffusional transport. This study developed a simple mono-component mucin model using M...
Bardoxolone methyl improves survival and reduces clinical measures of kidney injury in tumor-bearing mice treated with cisplatin [0.03%]
巴多索隆甲基改善顺铂治疗带瘤小鼠的生存率并减少肾脏损伤的临床指标
Lauren E Thompson,Stacey M Tuey,Paola Garcia Gonzalez et al.
Lauren E Thompson et al.
Objective: Acute kidney injury (AKI) occurs in approximately one-third of patients treated with cisplatin and there is an outstanding need for mitigation strategies to decrease the frequency and severity of cisplatin-indu...
Oral delivery of the non-β-blocking R-carvedilol enantiomer for skin cancer chemoprevention in SKH-1 mice [0.03%]
R-卡维地洛光学异构体的口服给药在小鼠皮肤癌化学预防中的作用研究
Pabitra K Sardar,Steven Yeung,Ruby Tow et al.
Pabitra K Sardar et al.
Purpose: Skin cancer remains the most prevalent cancer worldwide with its incidence continuously rising. Previous studies have demonstrated the efficacy of the β-blocker carvedilol and its non-β-blocking enantiomer R-ca...
Structured content and data management-enhancing acceleration in drug development through efficiency in data exchange [0.03%]
结构化内容与数据管理——通过高效的数据交换加速药物研发
Jill Beierle,Marquerita Algorri,Marisol Cortés et al.
Jill Beierle et al.
Innovation in pharmaceutical therapeutics is critical for the treatment of serious diseases with unmet medical need. To accelerate the approval of these innovative treatments, regulatory agencies throughout the world are increasingly adopti...