Investigating the impact of charge and hydrophilicity on peptide-mucin interactions using a simple mucin model [0.03%]
利用简单的粘蛋白模型研究电荷和亲水性对肽-粘蛋白相互作用的影响
Waleed M Elballa,Aiden Gregory,Teruna J Siahaan et al.
Waleed M Elballa et al.
In vitro models used to investigate drug diffusion face certain limitations and challenges because they omit for mucus interactions that could influence diffusional transport. This study developed a simple mono-component mucin model using M...
Bardoxolone methyl improves survival and reduces clinical measures of kidney injury in tumor-bearing mice treated with cisplatin [0.03%]
巴多索隆甲基改善顺铂治疗带瘤小鼠的生存率并减少肾脏损伤的临床指标
Lauren E Thompson,Stacey M Tuey,Paola Garcia Gonzalez et al.
Lauren E Thompson et al.
Objective: Acute kidney injury (AKI) occurs in approximately one-third of patients treated with cisplatin and there is an outstanding need for mitigation strategies to decrease the frequency and severity of cisplatin-indu...
Oral delivery of the non-β-blocking R-carvedilol enantiomer for skin cancer chemoprevention in SKH-1 mice [0.03%]
R-卡维地洛光学异构体的口服给药在小鼠皮肤癌化学预防中的作用研究
Pabitra K Sardar,Steven Yeung,Ruby Tow et al.
Pabitra K Sardar et al.
Purpose: Skin cancer remains the most prevalent cancer worldwide with its incidence continuously rising. Previous studies have demonstrated the efficacy of the β-blocker carvedilol and its non-β-blocking enantiomer R-ca...
Structured content and data management-enhancing acceleration in drug development through efficiency in data exchange [0.03%]
结构化内容与数据管理——通过高效的数据交换加速药物研发
Jill Beierle,Marquerita Algorri,Marisol Cortés et al.
Jill Beierle et al.
Innovation in pharmaceutical therapeutics is critical for the treatment of serious diseases with unmet medical need. To accelerate the approval of these innovative treatments, regulatory agencies throughout the world are increasingly adopti...
Extraction of niclosamide from commercial approved tablets into aqueous buffered solution creates potentially approvable oral and nasal sprays against COVID-19 and other respiratory infections [0.03%]
从市售批准的尼卡洛酰胺药片中提取到缓冲水溶液中，可创建可能被批准的用于治疗COVID-19和其他呼吸道感染的口服和鼻喷剂
David Needham
David Needham
Motivation: The low solubility, weak acid drug, niclosamide is a host cell modulator with broad-spectrum anti-viral cell-activity against many viruses, including stopping the SARS-CoV-2 virus from infecting cells in cell ...
Beate Bittner
Beate Bittner
Delivering customer-centric product presentations for biotherapeutics, such as monoclonal antibodies (mAbs), represents a long-standing and paramount area of engagement for pharmaceutical scientists. Activities include improving experience ...
Meeting report: Advancing accelerated regulatory review with Real-Time Oncology Review (RTOR), Project Orbis, and the Product Quality Assessment Aid [0.03%]
会议报告：利用实时肿瘤学审查（RTOR）、Project Orbis 和产品质控辅助工具促进加速监管审查的进展
Marquerita Algorri,Ajay Acharya,James Bernstein et al.
Marquerita Algorri et al.
The American Association of Pharmaceutical Scientists (AAPS) Chemistry, Manufacturing, and Controls (CMC) Community hosted two virtual panel discussions focusing on several novel regulatory review pathways for innovative oncology products: ...
Sardar M Jakaria,David E Budil,James Murtagh
Sardar M Jakaria
Glycopeptide antimicrobials are a class of naturally occurring or semi-synthetic glycosylated products that have shown antibacterial activity against gram-positive organisms by inhibiting cell-wall synthesis. In most cases, these drugs are ...
Safety and pharmacokinetics of a highly bioavailable resveratrol preparation (JOTROL TM) [0.03%]
一种高度生物利用度的白藜芦醇制剂(JOTROLTM)的安全性和药代动力学研究
Christopher Kemper,Dariush Benham,Shaun Brothers et al.
Christopher Kemper et al.
Resveratrol exhibits a wide range of biological properties, including anti-glycation, antioxidant, anti-inflammation, neuroprotective (including against advanced dementia and Alzheimer's disease), anti-cancer, and anti-aging activity in exp...
Molecular docking assisted exploration on solubilization of poorly soluble drug remdesivir in sulfobutyl ether-tycyclodextrin [0.03%]
基于分子对接的富马酸瑞德西韦在磺丁醚-α-环糊精中的溶解度增强研究
Yumeng Zhang,Zhouming Zhao,Kai Wang et al.
Yumeng Zhang et al.
Objective: To study structure-specific solubilization effect of Sulfobutyl ether-β-cyclodextrin (SBE-β-CD) on Remdesivir (RDV) and to understand the experimental clathration with the aid of quantum mechanics (QM), molec...