Human beta cells generated from pluripotent stem cells or cellular reprogramming for curing diabetes [0.03%]
人多能干细胞或细胞重编程生成的人β细胞在治愈糖尿病中的应用
Lauren N Randolph,Agamoni Bhattacharyya,Xiaojun Lance Lian
Lauren N Randolph
Diabetes is a group of metabolic diseases characterized by aberrantly high blood glucose levels caused by defects in insulin secretion, its action, or both, which affects approximately 30.3 million people (9.4% of the population) in the Uni...
CD140b (PDGFRβ) signaling in adipose-derived stem cells mediates angiogenic behavior of retinal endothelial cells [0.03%]
脂肪来源干细胞中的CD140b（PDGFRβ）信号通过介导视网膜内皮细胞的促血管生成行为发挥作用
Ramesh Periasamy,Sally L Elshaer,Rajashekhar Gangaraju
Ramesh Periasamy
Adipose-derived stem cells (ASCs) are multipotent mesenchymal progenitor cells that have functional and phenotypic overlap with pericytes lining microvessels in adipose tissue. The role of CD140b [platelet-derived growth factor receptor- β...
Surfactant Copolymer Annealing of Chemically Permeabilized Cell Membranes [0.03%]
化学透化的细胞膜的表面活性剂共聚物退火法
Hongfeng Chen,Colin McFaul,Igor Titushkin et al.
Hongfeng Chen et al.
Structural breakdown of the cell membrane is a primary mediator in trauma induced tissue necrosis. When membrane disruption exceeds intrinsic membrane sealing processes, biocompatible multi-block amphiphilic copolymer surfactants such as Po...
Vision for Functionally Decorated and Molecularly Imprinted Polymers in Regenerative Engineering [0.03%]
功能化和分子印迹聚合物在再生工程中的应用展望
John R Clegg,Marissa E Wechsler,Nicholas A Peppas
John R Clegg
The emerging field of regenerative engineering offers a great challenge and an even greater opportunity for materials scientists and engineers. How can we develop materials that are highly porous to permit cellular infiltration, yet possess...
Xiaobin Huang,Ritopa Das,Avi Patel et al.
Xiaobin Huang et al.
A wide range of techniques and methods are actively invented by clinicians and scientists who are dedicated to the field of musculoskeletal tissue regeneration. Biological, chemical, and physiological factors, which play key roles in muscul...
Nanofiber/Microsphere Hybrid Matrices In Vivo for Bone Regenerative Engineering: A Preliminary Report [0.03%]
纳米纤维/微球骨组织工程种子材料的复合载体的初步研究
Clarke Nelson,Yusuf Khan,Cato T Laurencin
Clarke Nelson
The demand for bone grafts has led to advances in regenerative engineering, a field at the intersection of advanced biomaterials, stem cell science, physics, developmental biology, and clinical translation. In this work, the authors evaluat...
Tatsuya Osaki,Jean C Serrano,Roger D Kamm
Tatsuya Osaki
In this study, we modeled lymphangiogenesis and vascular angiogenesis in a microdevice using a tissue engineering approach. Lymphatic vessels (LV) and blood vessels (BV) were fabricated by sacrificial molding with seeding human lymphatic en...
Timothy Chen,Gordana Vunjak-Novakovic
Timothy Chen
Timely reperfusion after a myocardial infarction is necessary to salvage the ischemic region; however, reperfusion itself is also a major contributor to the final tissue damage. Currently, there is no clinically relevant therapy available t...
Localized SDF-1α Delivery Increases Pro-Healing Bone Marrow-Derived Cells in the Supraspinatus Muscle Following Severe Rotator Cuff Injury [0.03%]
局部递送SDF-1α可增加严重肩袖损伤后有利于愈合的骨髓源细胞数量
L E Tellier,J R Krieger,A L Brimeyer et al.
L E Tellier et al.
To examine how the chemotactic agent stromal cell-derived factor-1alpha (SDF-1α) modulates the unique cellular milieu within rotator cuff muscle following tendon injury, we developed an injectable, heparin-based microparticle platform to l...
Enhanced differentiation of dental pulp cells cultured on microtubular polymer scaffolds in vitro [0.03%]
微管型高分子材料作为载体离体诱导牙髓干细胞分化增强的研究
Morteza Haeri,Karen Sagomonyants,Mina Mina et al.
Morteza Haeri et al.
Dental caries (tooth decay) is the most common chronic disease. Dental tissue engineering is a promising alternative approach to alleviate the shortcomings of the currently available restorative materials. Mimicking the natural extracellula...