Timothy Chen,Gordana Vunjak-Novakovic
Timothy Chen
Timely reperfusion after a myocardial infarction is necessary to salvage the ischemic region; however, reperfusion itself is also a major contributor to the final tissue damage. Currently, there is no clinically relevant therapy available t...
Localized SDF-1α Delivery Increases Pro-Healing Bone Marrow-Derived Cells in the Supraspinatus Muscle Following Severe Rotator Cuff Injury [0.03%]
局部递送SDF-1α可增加严重肩袖损伤后有利于愈合的骨髓源细胞数量
L E Tellier,J R Krieger,A L Brimeyer et al.
L E Tellier et al.
To examine how the chemotactic agent stromal cell-derived factor-1alpha (SDF-1α) modulates the unique cellular milieu within rotator cuff muscle following tendon injury, we developed an injectable, heparin-based microparticle platform to l...
Enhanced differentiation of dental pulp cells cultured on microtubular polymer scaffolds in vitro [0.03%]
微管型高分子材料作为载体离体诱导牙髓干细胞分化增强的研究
Morteza Haeri,Karen Sagomonyants,Mina Mina et al.
Morteza Haeri et al.
Dental caries (tooth decay) is the most common chronic disease. Dental tissue engineering is a promising alternative approach to alleviate the shortcomings of the currently available restorative materials. Mimicking the natural extracellula...
Regulation of regeneration by Heparan Sulfate Proteoglycans in the Extracellular Matrix [0.03%]
细胞外基质中肝素硫酸蛋白聚糖介导的再生调控机制研究
David M Gardiner
David M Gardiner
Just as the building of a house requires a blueprint, the rebuilding of lost or damaged body parts through regeneration requires a set of instructions for the assembly of the various tissues into the right places. Much progress has been mad...
Quantitative analysis of immune cell subset infiltration of supraspinatus muscle after severe rotator cuff injury [0.03%]
严重肩袖损伤后冈上肌免疫细胞亚群浸润的量化分析
J R Krieger,L E Tellier,M T Ollukaren et al.
J R Krieger et al.
Rotator cuff tears cause muscle degeneration that is characterized by myofiber atrophy, fatty infiltration, and fibrosis and is minimally responsive to current treatment options. The underlying pathogenesis of rotator cuff muscle degenerati...
Kenneth S Ogueri,Jorge L Escobar Ivirico,Lakshmi S Nair et al.
Kenneth S Ogueri et al.
The occurrence of musculoskeletal tissue injury or disease and the subsequent functional impairment is at an alarming rate. It continues to be one of the most challenging problems in the human health care. Regenerative engineering offers a ...
Aging Affects Bone Marrow Macrophage Polarization: Relevance to Bone Healing [0.03%]
衰老影响骨髓巨噬细胞极化：与骨折愈合的关系
E Gibon,F Loi,Luis A Córdova et al.
E Gibon et al.
Macrophages are an important component of the inflammatory cascade by initiating and modulating the processes leading to tissue regeneration and bone healing. Depending on the local environment, macrophages can be polarized into M1 (pro-inf...
Multiscale Poly-(ϵ-caprolactone) Scaffold Mimicking Nonlinearity in Tendon Tissue Mechanics [0.03%]
仿生肌腱非线性力学性能的聚-（ε-己内酯）多尺度支架结构设计与制备
Brittany L Banik,Gregory S Lewis,Justin L Brown
Brittany L Banik
Regenerative medicine plays a critical role in the future of medicine. However, challenges remain to balance stem cells, biomaterial scaffolds, and biochemical factors to create successful and effective scaffold designs. This project analyz...
Engineering nanomaterials to address cell-mediated inflammation in atherosclerosis [0.03%]
工程化纳米材料以解决动脉粥样硬化中的细胞介导炎症问题
Sean Allen,Yu-Gang Liu,Evan Scott
Sean Allen
Atherosclerosis is an inflammatory disorder with a pathophysiology driven by both innate and adaptive immunity and a primary cause of cardiovascular disease (CVD) worldwide. Vascular inflammation and accumulation of foam cells and their pro...
Rafid Kasir,Varadraj N Vernekar,Cato T Laurencin
Rafid Kasir
Injury to the articular cartilage occurs commonly in the general population and undergoes minimal spontaneous healing. Traditional methods of cartilage repair provide no long-term cure and are significant causes of morbidity. For this reaso...