Olivia P Dotson,Sherina Malkani,Inkyung Kang et al.
Olivia P Dotson et al.
Purpose: 3D printing has accelerated tissue engineering by enabling rapid fabrication of bioprinted tissues from a variety of soft biomaterials. Yet, an ongoing challenge is that for many bioprinting technologies, the mat...
Multiple Drug Delivery Ability of Calcium Phosphate Scaffolds promotes Osteogenic Gene Expression in In Vitro Co‑culture Model [0.03%]
基于体外共培养体系的钙磷陶瓷多药缓释能力促进成骨分化及基因表达
Naboneeta Sarkar,Yongdeok Jo,Priya Kushram et al.
Naboneeta Sarkar et al.
Purpose: This study investigates the incorporation of curcumin, resveratrol, and vitamin D3 into polymer-integrated calcium phosphate (CaP) scaffolds to assess their effects on osteogenic gene expression and osteosarcoma ...
Irina Kopyeva,Cole A DeForest
Irina Kopyeva
Purpose: Enzymatic reactions offer many advantages for hydrogel synthesis and modification, due to their gentle reaction conditions, biocompatibility, and diversity of substrates. ...
Epitope Imprinted Nanoparticles as Customized Synthetic Antibodies for Biorecognition in Theranostics [0.03%]
用于诊疗中生物识别的表位印迹纳米粒子定制型合成抗体
Simão P B Teixeira,Rui L Reis,Rui M A Domingues
Simão P B Teixeira
As medicine advances towards an era of personalized and targeted therapies, the need for precise and reliable molecular recognition elements becomes increasingly critical. These elements are essential for directing therapeutic agents to spe...
A Pressure Regulator Platform for Applying Biomechanical Stimuli on Organ-on-A-Chip Systems with Physiological and Pathological Relevancy [0.03%]
一种压力调节平台 可在器官芯片系统中施加生理和病理相关的生物力学刺激
Carlos Ezio Garciamendez-Mijares,Francisco Aguilar Rojas,David S Rendon Ruiz et al.
Carlos Ezio Garciamendez-Mijares et al.
Purpose: The organ-on-a-chip (OOC) technology has transformed in vitro modeling by replicating human organ microenvironments with high fidelity, offering improved platforms for drug discovery and disease modeling. However...
Silk Fibroin Particle-Laden Sponges as a Multiphase Controlled Release Platform [0.03%]
丝素蛋白颗粒负载海绵作为多相控制释放平台
Marisa O Pacheco,Cathrine A Beshay,Whitney L Stoppel
Marisa O Pacheco
Purpose: Silk fibroin-based biomaterials have shown utility across regenerative medicine applications due to their ability to provide robust mechanical support and deliver bioactive cargo. To achieve diverse functions, fi...
Niclosamide-Loaded Polyanhydride Nanoparticles to Combat Gemcitabine Resistance in Pancreatic Cancer [0.03%]
用于对抗胰腺癌吉西他滨耐药的 niclosamide 载聚阴离子聚合物纳米颗粒疗法
Brianna M White,Venugopal Gunda,Susheel Kumar Nethi et al.
Brianna M White et al.
Purpose: Pancreatic cancer (PC) is a highly lethal malignancy and lacks effective treatments. Current chemotherapies, including gemcitabine (Gem) in combination treatment regimens, produce dose-limiting toxicity, drug res...
Regenerative Glycopeptide Scaffolds Enhance BMP-4 Activity To Treat Pediatric Glioma [0.03%]
再生糖肽支架增强BMP-4活性以治疗儿童胶质瘤
Cara S Smith,Timmy Fyrner,Nicholas A Sather et al.
Cara S Smith et al.
Abstract: Pediatric high-grade gliomas (pHGGs) are among the most devastating cancers in children. These tumors have remained largely incurable, despite the many approaches that have been applied for their treatment. Here...
Safety and Biocompatibility of a Spray-Dried Influenza Microparticle Vaccine in Mice [0.03%]
喷雾干燥的流感微粒疫苗的小鼠安全性和生物相容性研究
A C Siddoway,D Verhoeven,T A Harm et al.
A C Siddoway et al.
Abstract: Influenza virus is a persistent source of morbidity and moribundity, and effective disease control requires ever-evolving effective vaccines. In this work, we evaluate the safety and biocompatibility of two nove...
Evaluation of an Antioxidative Thermoresponsive Polydiolcitrate Hydrogel in a Novel Diabetic Pig Impaired Wound Healing Model [0.03%]
评估抗氧化热响应性聚二醇基丙交酯凝胶在新的糖尿病猪伤口愈合受损模型中的应用
Maria Mendez-Santos,Yunxiao Zhu,Mouhamad Alloosh et al.
Maria Mendez-Santos et al.
Purpose: Non-healing chronic wounds in diabetic patients pose a significant health and economic burden. We have previously shown that the citrate-based thermoresponsive macromolecule poly(polyethylene glycol citrate-co-N-...