Silk Fibroin Particle-Laden Sponges as a Multiphase Controlled Release Platform [0.03%]
丝素蛋白颗粒负载海绵作为多相控制释放平台
Marisa O Pacheco,Cathrine A Beshay,Whitney L Stoppel
Marisa O Pacheco
Purpose: Silk fibroin-based biomaterials have shown utility across regenerative medicine applications due to their ability to provide robust mechanical support and deliver bioactive cargo. To achieve diverse functions, fi...
Niclosamide-Loaded Polyanhydride Nanoparticles to Combat Gemcitabine Resistance in Pancreatic Cancer [0.03%]
用于对抗胰腺癌吉西他滨耐药的 niclosamide 载聚阴离子聚合物纳米颗粒疗法
Brianna M White,Venugopal Gunda,Susheel Kumar Nethi et al.
Brianna M White et al.
Purpose: Pancreatic cancer (PC) is a highly lethal malignancy and lacks effective treatments. Current chemotherapies, including gemcitabine (Gem) in combination treatment regimens, produce dose-limiting toxicity, drug res...
Regenerative Glycopeptide Scaffolds Enhance BMP-4 Activity To Treat Pediatric Glioma [0.03%]
再生糖肽支架增强BMP-4活性以治疗儿童胶质瘤
Cara S Smith,Timmy Fyrner,Nicholas A Sather et al.
Cara S Smith et al.
Abstract: Pediatric high-grade gliomas (pHGGs) are among the most devastating cancers in children. These tumors have remained largely incurable, despite the many approaches that have been applied for their treatment. Here...
Safety and Biocompatibility of a Spray-Dried Influenza Microparticle Vaccine in Mice [0.03%]
喷雾干燥的流感微粒疫苗的小鼠安全性和生物相容性研究
A C Siddoway,D Verhoeven,T A Harm et al.
A C Siddoway et al.
Abstract: Influenza virus is a persistent source of morbidity and moribundity, and effective disease control requires ever-evolving effective vaccines. In this work, we evaluate the safety and biocompatibility of two nove...
Evaluation of an Antioxidative Thermoresponsive Polydiolcitrate Hydrogel in a Novel Diabetic Pig Impaired Wound Healing Model [0.03%]
评估抗氧化热响应性聚二醇基丙交酯凝胶在新的糖尿病猪伤口愈合受损模型中的应用
Maria Mendez-Santos,Yunxiao Zhu,Mouhamad Alloosh et al.
Maria Mendez-Santos et al.
Purpose: Non-healing chronic wounds in diabetic patients pose a significant health and economic burden. We have previously shown that the citrate-based thermoresponsive macromolecule poly(polyethylene glycol citrate-co-N-...
Sustained Delivery of Chondrogenic Molecules Using Sugar Glass Nanoparticle-Integrated Fibrous Scaffolds for Cartilage Tissue Engineering [0.03%]
基于糖玻璃纳米颗粒的纤维支架持续递送软骨分化分子用于软骨组织工程
To Wang,Yiwei Dong,Marcus T Cicerone et al.
To Wang et al.
Purpose: Biomaterial scaffolds capable of controlled release of bioactive molecules hold significant potential in tissue engineering, offering a promising avenue to enhance tissue regeneration. They provide localized and ...
Karen L Xu,Robert L Mauck,Jason A Burdick
Karen L Xu
Purpose: The extracellular environment is critical for cell migration in three-dimensions (3D), which has been understudied when compared to cell migration on two-dimensional (2D) substrates. In 3D, cells must degrade or ...
Role of FGF2 in promoting osteogenic differentiation for craniofacial bone regeneration [0.03%]
FGF2在颅面骨再生中促进成骨分化的机制研究
Xianrui Yang,Peter X Ma
Xianrui Yang
Fibroblast growth factor II (FGF2), or basic fibroblast growth factor (bFGF), is an important regulator in bone and craniofacial development. FGF2 regulates cell survival, proliferation, migration, multilineage differentiation, and stemness...
Localized gene delivery and enhanced cell-cell communication via bio-orthogonal polymer coatings [0.03%]
用于局部基因传递和增强细胞间通信的生物正交聚合物涂层
Merjem Mededovic,Xiaoyang Zhong,David H Kohn et al.
Merjem Mededovic et al.
Surface modification of biomaterials, particularly by adding bioactive coatings, enhances cell-material interactions at the nanoscale, improving implant performance at the macroscale. One approach involves gene delivery via surface-bound co...
Jordyn M Wyse,Priscilla Lopez,Dimitrios Miserlis et al.
Jordyn M Wyse et al.
The biomedical research of nucleic acids as therapeutics and their medical applications has been steadily progressing. Identifying the fundamental regulatory roles of nucleic acids and their potential use in the medical field is of major pu...