Regulation of Stem Cell Function in an Engineered Vocal Fold-Mimetic Environment [0.03%]
声带仿生微环境调控干细胞功能
Aidan B Zerdoum,Pooya Saberi,Alexander J Stuffer et al.
Aidan B Zerdoum et al.
Human mesenchymal stem cells (hMSCs) have been proposed as therapeutic cells for the treatment of vocal fold (VF) scarring. Although functional recovery was observed in animal models after stem cell injection, it is not clear how injected s...
Culture of Mesenchymal Stem Cells in a Hydrogel Model of Vocal Fold Lamina Propria [0.03%]
声带固有层水凝胶模型中的间充质干细胞培养
Aidan B Zerdoum,Alexander J Stuffer,Hossein K Heris et al.
Aidan B Zerdoum et al.
Stem cell injection has been proposed as an alternative approach for the restoration of vocal fold (VF) function in patients with VF scarring. To assess the therapeutic efficacy of this treatment strategy, we evaluated the behaviors of huma...
Localized Induction of Gene Expression in Embryonic Stem Cell Aggregates Using Holographic Optical Tweezers to Create Biochemical Gradients [0.03%]
使用全息光学镊子创建生化梯度以在胚胎干细胞聚集体中进行局部基因表达诱导
Glen R Kirkham,James Ware,Thomas Upton et al.
Glen R Kirkham et al.
Three-dimensional (3D) cell models that mimic the structure and function of native tissues are enabling more detailed study of physiological and pathological mechanisms in vitro. We have previously demonstrated the ability to build and mani...
Increased NF-kB activity in osteoprogenitor-lineage cells impairs the balance of bone versus fat in the marrow of skeletally mature mice [0.03%]
骨龄成熟小鼠骨髓中成软骨细胞系细胞的NF-κB活性增强会破坏骨与脂肪之间的平衡
Tzuhua Lin,Jukka Pajarinen,Yusuke Kohno et al.
Tzuhua Lin et al.
"Senile osteoporosis" is defined as significant aging-associated bone loss, and is accompanied by increased fat in the bone marrow. The proportion of adipocytes in bone marrow is inversely correlated with bone formation, and is associated w...
A 30% Volumetric Muscle Loss Does Not Result in Sustained Functional Deficits after a 90-Day Recovery in Rats [0.03%]
30%体积肌肉损失后90天大鼠功能恢复良好
Emmanuel E Vega-Soto,Brittany L Rodriguez,Rachel E Armstrong et al.
Emmanuel E Vega-Soto et al.
Volumetric muscle loss (VML) is defined as the loss of skeletal muscle tissue which exceeds the body's repair capabilities leading to sustained functional deficits over time. Some etiologies leading to VML include traumatic injuries, congen...
POLYMERIC BIOMATERIALS FOR SCAFFOLD-BASED BONE REGENERATIVE ENGINEERING [0.03%]
用于骨组织再生的支架材料聚乙烯亚胺类生物材料
Kenneth S Ogueri,Tahereh Jafari,Jorge L Escobar Ivirico et al.
Kenneth S Ogueri et al.
Reconstruction of large bone defects resulting from trauma, neoplasm, or infection is a challenging problem in reconstructive surgery. The need for bone grafting has been increasing steadily partly because of our enhanced capability to salv...
The Maturation of Tissue-Engineered Skeletal Muscle Units following 28-Day Ectopic Implantation in a Rat [0.03%]
体外构建的骨骼肌组织单元异位植入28天后的成熟度变化分析
Brittany L Rodriguez,Shelby E Florida,Keith W VanDusen et al.
Brittany L Rodriguez et al.
Volumetric muscle loss (VML) is a loss of skeletal muscle that results in a sustained impairment of function and is often accompanied by physical deformity. To address the need for more innovative repair options, our laboratory has develope...
Nanofibers as Bioinstructive Scaffolds Capable of Modulating Differentiation through Mechanosensitive Pathways for Regenerative Engineering [0.03%]
纳米纤维作为能够通过机械敏感途径调节分化以用于再生工程的生物指导支架
Daniel T Bowers,Justin L Brown
Daniel T Bowers
Bioinstructive scaffolds encode information in the physical shape and size of materials to direct cell responses. Electrospinning nanofibers is a process that offers control over scaffold architecture and fiber diameter, while providing ext...
Deborah D Chin,Sampreeti Chowdhuri,Eun Ji Chung
Deborah D Chin
Cardiovascular disease (CVD) including atherosclerosis is the leading cause of death worldwide. As CVDs and atherosclerosis develop, plaques begin to form in the blood vessels and become calcified. Calcification within the vasculature and a...
Evaluating Angiogenic Potential of Small Molecules Using Genetic Network Approaches [0.03%]
利用基因网络方法评估小分子的血管生成潜力
Anusuya Das,Parker Merrill,Jennifer Wilson et al.
Anusuya Das et al.
Control of microvascular network growth is critical to treatment of ischemic tissue diseases and enhancing regenerative capacity of tissue engineering implants. Conventional therapeutic strategies for inducing angiogenesis aim to deliver on...