The Effects of Engineered Skeletal Muscle on Volumetric Muscle Loss in The Tibialis Anterior Of Rat After Three Months In Vivo [0.03%]
植入工程化骨骼肌修复体积性肌肉缺损三个月后的组织学评价研究
Genevieve P Nutter,Keith W VanDusen,Shelby E Florida et al.
Genevieve P Nutter et al.
Volumetric muscle loss (VML) is traumatic, degenerative, or surgical loss of skeletal muscle that exceeds the regenerative capacity of the remaining muscle, thus resulting in impaired muscle function. In humans, the loss of 30% or more mass...
Xiaoyan Tang,Leila Daneshmandi,Guleid Awale et al.
Xiaoyan Tang et al.
Skeletal muscles have the intrinsic ability to regenerate after minor injury, but under certain circumstances such as severe trauma from accidents, chronic diseases or battlefield injuries the regeneration process is limited. Skeletal muscl...
Identification of Heparan-Sulfate Rich Cells in the Loose Connective Tissues of the Axolotl (Ambystoma mexicanum) with the Potential to Mediate Growth Factor Signaling during Regeneration [0.03%]
墨西哥钝头螈（Ambystoma mexicanum）疏松结缔组织中富含硫酸肝素的细胞鉴定其具有介导再生过程中生长因子信号传导的潜能
T Otsuka,A Q Phan,C T Laurencin et al.
T Otsuka et al.
Limb regeneration is the outcome of a complex sequence of events that are mediated by interactions between cells derived from the tissues of the amputated stump. Early in regeneration, these interactions are mediated by growth factor/morpho...
A combinatorial library of biodegradable polyesters enables non-viral gene delivery to post-mitotic human stem cell-derived polarized RPE monolayers [0.03%]
可生物降解的组合聚酯库能够实现非病毒基因向分化的传递
Bibhudatta Mishra,David R Wilson,Srinivas R Sripathi et al.
Bibhudatta Mishra et al.
Safe and effective delivery of DNA to post-mitotic cells, especially highly differentiated cells, remains a challenge despite significant progress in the development of gene delivery tools. Biodegradable polymeric nanoparticles (NPs) offer ...
Potency of Mesenchymal Stem Cell and Its Secretome in Treating COVID-19 [0.03%]
间充质干细胞及其分泌组治疗COVID-19的潜力
Angliana Chouw,Tiana Milanda,Cynthia Retna Sartika et al.
Angliana Chouw et al.
Abstract: The COVID-19 disease, which is caused by the novel coronavirus, SARS-CoV-2, has affected the world by increasing the mortality rate in 2020. Currently, there is no definite treatment for COVID-19 patients. Sever...
Biomimetic electroconductive nanofibrous matrices for skeletal muscle regenerative engineering [0.03%]
仿生电导纳米纤丝基质在骨骼肌组织再生工程中的应用
Xiaoyan Tang,Nikoo Saveh-Shemshaki,Ho-Man Kan et al.
Xiaoyan Tang et al.
The regeneration of the muscles of the rotator cuff represents a grand challenge in musculoskeletal regenerative engineering. Several types of matrices have been proposed for skeletal muscle regeneration. However, biomimetic matrices to pro...
Bioinspired Scaffold Designs for Regenerating Musculoskeletal Tissue Interfaces [0.03%]
仿生支架设计在肌肉骨骼组织界面再生中的应用
Mohammed A Barajaa,Lakshmi S Nair,Cato T Laurencin
Mohammed A Barajaa
The musculoskeletal system works at a very advanced level of synchrony, where all the physiological movements of the body are systematically performed through well-organized actions of bone in conjunction with all the other musculoskeletal ...
Differentiation of Adipose Tissue-Derived CD34+/CD31- Cells into Endothelial Cells In Vitro [0.03%]
体外脂肪来源CD34+/CD31-细胞向内皮细胞分化
Anoosha Forghani,Srinivas V Koduru,Cong Chen et al.
Anoosha Forghani et al.
In this study, CD34+/CD31- progenitor cells were isolated from the stromal vascular fraction (SVF) of adipose tissue using magnetic activated cell sorting. The endothelial differentiation capability of these cells in vitro was evaluated by ...
Regenerative Cell-Based Therapies: Cutting Edge, Bleeding Edge, and Off the Edge [0.03%]
再生细胞疗法：前沿、前缘和越界疗法
Cato T Laurencin,Aneesah McClinton
Cato T Laurencin
With the emergence of cell-based therapies as viable treatment options readily accessible to patients, the scientific community and public have raised concerns regarding consumer accessibility and regulation enforcement. Opposing viewpoints...
The Challenge of Variability in Chimeric Antigen Receptor T cell Manufacturing [0.03%]
嵌合抗原受体T细胞制造中的变异性挑战
Andrew D Fesnak
Andrew D Fesnak
Autologous Chimeric Antigen Receptor (CAR) T cell manufacturing involves the modification and expansion of T cells obtained by apheresis collection from a patient. The mechanism of apheresis collection and the specific clinical features see...