Biophysical adaptations of circulating tumor cells undergoing metastasis [0.03%]
发生转移的循环肿瘤细胞的生物物理适应性变化
Lanfeng Liang,Xiao Song,Shida Wang et al.
Lanfeng Liang et al.
Circulating tumor cells (CTCs) are cancerous cells that break away from the primary tumor, enter the bloodstream, and travel to another part of the body. Research into CTCs, particularly their biological phenotypes and molecular mechanisms,...
Multiscale measurement of brain tissue and cell biomechanics using a mouse model [0.03%]
基于小鼠模型的大脑组织及细胞多重尺度力学测量研究
Runke Wang,Suo Qian,Huijing Jin et al.
Runke Wang et al.
The intricate structure of the brain at various scales is linked to its functional and biomechanical properties. Since understanding the biomechanical properties is vital for comprehending brain diseases, development, and injuries, measurem...
Identifying vascular stiffening-sensitive macrophages through integration of single-cell transcriptomics and imaging flow cytometry [0.03%]
通过单细胞转录组和成像流式细胞术整合鉴定血管硬化敏感型巨噬细胞
Jin Wang,Jiyin Wang,Yuting Zhang et al.
Jin Wang et al.
Increased extracellular matrix (ECM) stiffness, a hallmark of risk in cardiovascular disease (CVD), is closely associated with inflammation triggered by immune cell infiltration in the vessel wall. While numerous immunotherapies targeting i...
Chaoyang Song,Mengqi Zhu,Rebecca G Wells et al.
Chaoyang Song et al.
The care of patients with cholestatic liver diseases such as primary sclerosing cholangitis (PSC) is challenging, partly due to the lack of knowledge of disease pathogenesis and suitable in vitro models for disease modeling and drug screeni...
Cholesterol modulates vesicle clustering mediated by alpha-synuclein in a nonlinear fashion [0.03%]
胆固醇通过非线性方式调节α-突触核蛋白介导的囊泡聚集作用
Owen Tyoe,Chinta Aryal,Jiajie Diao
Owen Tyoe
α-Synuclein (α-Syn) is a presynaptic protein primarily associated with Parkinson's disease and other neurodegenerative diseases. The cholesterol content in SV membranes regulates α-Syn binding to synaptic vesicles, changing its function ...
Multiscale analysis of mechanical stress in muscle under static and dynamic loading [0.03%]
静动态荷载下肌肉应力的多尺度分析
Xue Ke,Yansong Lu,Linjing Peng et al.
Xue Ke et al.
Deep tissue injury (DTI) is a serious condition primarily triggered by prolonged mechanical loading rather than short-term excessive force. Cyclic force stimulation has been shown to enhance cellular protection; however, the biomechanical m...
Peipei Xing,Xinyue Wu,Mengliang Zhu
Peipei Xing
Phototheranostic, as an emerging non-invasive cancer diagnosis and treatment modality, combines optical imaging with phototherapy, showcasing advantages such as precision, high efficiency, and low toxicity. The core of phototheranostics lie...
Bacterial restriction-modification systems: mechanisms of defense against phage infection [0.03%]
细菌限制修饰系统：防御噬菌体感染的机制
Haoyang Kang,Ang Gao,Yalan Zhu
Haoyang Kang
Bacteria have evolved various defense mechanisms against bacteriophage invasion, driven by a long-term evolutionary arms race. Among them, restriction-modification (R-M) systems, which protect bacteria by DNA restriction and modification, a...
Single-cell atlas of peripheral blood mononuclear cells in pregnant women with hyperemesis gravidarum [0.03%]
妊娠剧呕孕妇外周血单个核细胞的单细胞图谱
Ke Wu,Xueqiang Yao,Jie Wen et al.
Ke Wu et al.
In early pregnancy, approximately 70% of women experience nausea and vomiting, with hyperemesis gravidarum (HG) can potentially lead to severe fluid and nutritional imbalances that require hospitalization. Although HG often resolves on its ...