Leveraging pre-trained AI models for robust promoter sequence design in synthetic biology [0.03%]
利用预训练AI模型进行合成生物学中的稳健启动子序列设计
Gui Yang,Yijie Chen,Qinghua Guo et al.
Gui Yang et al.
Although artificial intelligence (AI) has begun to be applied in synthetic biology, it is limited by its reliance on large amounts of high-quality data, which presents a significant challenge in synthetic biology. Pre-trained models have pr...
Xiaoxuan Zeng,Xushan Ma,Yueping Bai et al.
Xiaoxuan Zeng et al.
Ferroptosis is a new form of cell death driven by iron-dependent lipid peroxidation. Thus, it is closely related to the lipid and iron metabolism. Accumulating evidence has suggested mitochondria, the center of cell metabolism, are importan...
Increased impact of GPIb receptors on platelet adhesion under flow in severe COVID-19 [0.03%]
新冠肺炎重症患者血小板滚转中GPIb受体作用增强
Yuliya Avtaeva,Konstantin Guria,Ivan Melnikov et al.
Yuliya Avtaeva et al.
Rapid identification of antigen-specific TCRs for cancer immunotherapy [0.03%]
用于癌症免疫治疗的抗原特异性TCR的快速鉴定
Min Jiang,Wenling Wang,Shuguang Tan
Min Jiang
T cell receptors (TCRs) can recognize peptides presented by major histocompatibility complex (MHC) molecules, referred to as HLA in humans, which enables the targeted eradication of tumor cells expressing specific antigens. In recent years,...
A practical guide for characterization of novel CRISPR-Cas systems with Pro-CRISPR factors [0.03%]
带有Pro-CRISPR因子的新型CRISPR-Cas系统的鉴定与特性分析指南
Ao Sun,Shu-Lin Jin,Jun-Jie Gogo Liu
Ao Sun
The emergence of advanced genome editing technologies has revolutionized research in life sciences, offering an unprecedented way to uncover unknown biological functions and innovative therapeutic strategies. Among all genome editing tools,...
Global research trends on the relationship between RNA m5C modification and cancer progression: a comprehensive visualization and bibliometric analysis (1900-2024) [0.03%]
全球RNA m5C修饰与癌症进展关系的研究趋势：1900-2024可视化和文献计量分析
Peipei Yao,Fei Chen,Nan Zhang et al.
Peipei Yao et al.
The m5C modification is one of the widely occurring modifications on RNA. In recent years, m5C modification on RNA has increasingly become a focal point in cancer research. Nevertheless, investigating scientific and quantitative research on...
Intravital mesoscale optical imaging: challenges, techniques, and future perspectives [0.03%]
活体内介观光学成像：挑战、技术及未来展望
Mingrui Wang,Jiamin Wu,Qionghai Dai
Mingrui Wang
Intravital mesoscale imaging plays a crucial role in bridging the gap between cellular and organ-level investigations by enabling high-resolution visualization across large fields of view. Continuous advancements in optical microscopy have ...
Mohammad Zaheer Ansari
Mohammad Zaheer Ansari
We describe the statistical characteristics of optical speckle patterns formed by illuminating biological tissues, commonly called biospeckles. The predominant techniques used to gather information from the movement of speckle patterns are ...