Impact of TNF-alpha -308 G/A polymorphism on response to TNF inhibitors in Tunisian patients with inflammatory rheumatic diseases [0.03%]
肿瘤坏死因子α-308G/A多态性对突尼斯炎症风湿病患者肿瘤坏死因子抑制剂疗效的影响
Ines Mahmoud,Syrine Zanned,Leila Rouached et al.
Ines Mahmoud et al.
Objectives: To evaluate the impact of the TNF-α promoter SNP -308G/A on therapeutic response, serum drug levels, and immunogenicity of TNF inhibitors in chronic inflammatory rheumatic diseases. ...
MicroRNA sequencing reveals modulation of neurodegenerative miRNAs by Withania somnifera in human neuroblastoma SK-N-SH cells [0.03%]
微序技术揭示印度草药冬梨调节神经退行性microRNAs的作用
Shanavas Syed Mohamed Puhari,Dilip Mehta,Anand Bhaskar et al.
Shanavas Syed Mohamed Puhari et al.
Objectives: Withania somnifera (WS) is known for its adaptogenic benefits; however, its beneficial effects in neurodegenerative diseases have not been fully explored. MicroRNAs (miRNAs) are small noncoding RNAs whose role...
Maria Zofia Lisiecka,Joanna Luczak
Maria Zofia Lisiecka
Allergic diseases are common among women of reproductive age, which necessitates the use of antihistamine therapy during pregnancy while ensuring safety for both the mother and the foetus. The study aimed to determine the safety profile, ph...
MDMA-induced CYP2D6 inhibition: concentration-dependent variability using dextromethorphan as a probe [0.03%]
用右美沙芬作为探针的3,4-亚甲基二氧基甲基苯丙胺对CYP2D6抑制：浓度依赖性差异
Faezeh Ahmadi,Hoda Lavasani,Mohammadhosein Keshvadi et al.
Faezeh Ahmadi et al.
Objectives: Ecstasy is commonly abused due to entactogenic effects. Although our previous studies on isolated perfused rat model confirmed inhibition of CYP2D6 by MDMA, the time for enzyme recovery was different when mirt...
Allergic reactions to anaesthetics in surgery: current challenges and perspectives [0.03%]
手术中麻醉剂过敏反应的现状、挑战和前景展望
Maria Zofia Lisiecka,Joanna Luczak
Maria Zofia Lisiecka
Introduction: This study was conducted to assess the current state of issues related to AR to anaesthetics used in surgical procedures. Contents: ...
Superior seizure control with first-line levetiracetam in very low birth weight neonates: a 10-year comparative retrospective study [0.03%]
左乙拉西坦作为一线抗癫痫药物可更好地控制极低体重早产儿的癫痫发作：一项为期十年的回顾性比较研究
Coşkun Armağan,Begüm Nişancı Öğünçlü,Mustafa Halk et al.
Coşkun Armağan et al.
Objectives: Very low birth weight (VLBW) infants are at disproportionately high risk for neonatal seizures, yet optimal first-line antiseizure medication (ASM) strategies in this vulnerable population remain a matter of d...
Allele frequencies of pharmacogenetic biomarkers and genomic ancestry in a sample of the Cuban population [0.03%]
古巴人口样本中药物基因组生物标志物的等位基因频率和基因组血统分布
Hilda Roblejo-Balbuena,Yaima Zuñiga-Rosales,Goitybell Martínez-Téllez et al.
Hilda Roblejo-Balbuena et al.
Objectives: A growing set of drugs includes a pharmacogenetic biomarker as a requirement before prescription. This study aims to determine the frequency of allelic variants with functional repercussions in clinically rele...
The 10+2 Santorini conference: systems medicine and personalised health therapy. The odyssey from hope to practice: "patient first - keep Ithaca always in your mind" Santorini, Greece, 26-29 May 2026 [0.03%]
第10届+2圣托里尼大会：系统医学与个性化健康疗法。从希望到实践的 Odyssey：“患者第一——始终将伊塔卡岛铭记于心”希腊圣托里尼，2026年5月26-29日
Sofia Siest
Sofia Siest
Drug metabolism and personalized therapy is switching its publication model to open access [0.03%]
药物代谢与个性化治疗开放获取出版模式转换公告
Suzanne Mekking,Ingrid Fricke-Galindo,Adrián LLerena
Suzanne Mekking
Regulatory discrepancies and patient-safety risks from the continued marketing of withdrawn medicines in Ecuador, Colombia, and Peru (2014-2025) [0.03%]
厄瓜多尔、哥伦比亚和秘鲁已退市但仍在市场销售的部分药品存在监管不一致和患者安全风险（2014-2025年）
Aida Miranda,Camila Lopez,Shabnam Santos et al.
Aida Miranda et al.
Objectives: To evaluate whether international decisions to withdraw medicines for safety, efficacy, or commercial reasons were reflected in the regulatory actions of Ecuador, Colombia, and Peru. ...