Down syndrome: Distribution of brain amyloid in mild cognitive impairment [0.03%]
唐氏综合征：轻度认知障碍患者脑淀粉样变性的分布规律
David B Keator,Michael J Phelan,Lisa Taylor et al.
David B Keator et al.
Introduction: Down syndrome (DS) is associated with a higher risk of dementia. We hypothesize that amyloid beta (Aβ) in specific brain regions differentiates mild cognitive impairment in DS (MCI-DS) and test these hypoth...
Response to peer commentaries: Composite cognitive and functional measures for early stage Alzheimer's disease trials [0.03%]
对同行评论的回应：阿尔茨海默病早期阶段临床试验中综合认知和功能测量指标的作用
Lon S Schneider,Terry E Goldberg
Lon S Schneider
Composite cognitive and functional measures for early stage Alzheimer's disease trials [0.03%]
用于阿尔茨海默病早期临床试验的综合认知和功能测量方法
Lon S Schneider,Terry E Goldberg
Lon S Schneider
Introduction: Composite scales have been advanced as primary outcomes in early stage Alzheimer's disease trials, and endorsed by the U.S. Food and Drug Administration (FDA) for pivotal trials. They are generally composed ...
Associations between NIH Toolbox Cognition Battery and in vivo brain amyloid and tau pathology in non-demented older adults [0.03%]
NIH认知工具箱与非痴呆老年人脑内淀粉样蛋白和tau病理之间的关系
Beth E Snitz,Dana L Tudorascu,Zheming Yu et al.
Beth E Snitz et al.
Introduction: The National Institutes of Health (NIH) Toolbox Cognition Battery (NIHTB-CB) was developed to be a common assessment metric across a broad array of research studies. We investigated associations between NIHT...
The influence of diversity on the measurement of functional impairment: An international validation of the Amsterdam IADL Questionnaire in eight countries [0.03%]
多样性对功能障碍测量的影响：八个国家中阿姆斯特丹iadl问卷的国际验证研究
Mark A Dubbelman,Merike Verrijp,David Facal et al.
Mark A Dubbelman et al.
Introduction: To understand the potential influence of diversity on the measurement of functional impairment in dementia, we aimed to investigate possible bias caused by age, gender, education, and cultural differences. ...
Plasma pyroglutamate-modified amyloid beta differentiates amyloid pathology [0.03%]
等离子pyroglutamate修饰的淀粉样蛋白β区分淀粉样病理学
Pei-Ning Wang,Kun-Ju Lin,Huei-Chun Liu et al.
Pei-Ning Wang et al.
Introduction: Pyroglutamate-modified amyloid β (AβpE3) could be a biomarker for Aβ plaque pathology in the brain. An ultra-high-sensitive assay is needed for detecting AβpE3-40. ...
Intrathecal 99mTc-DTPA imaging of molecular passage from lumbar cerebrospinal fluid to brain and periphery in humans [0.03%]
人脑和外周组织从腰池脑脊液分子转运的99mTc-DTPA影像学研究
Ajay Verma,Jacob Y Hesterman,J Levi Chazen et al.
Ajay Verma et al.
Introduction: Cerebrospinal fluid (CSF) molecular exchange with brain interstitial fluid (ISF) and periphery is implicated in neurological disorders but needs better quantitative clinical assessment approaches. ...
Henry Brodaty,Michael H Connors
Henry Brodaty
Dementia has a wide range of reversible causes. Well known among these is depression, though other psychiatric disorders can also impair cognition and give the appearance of neurodegenerative disease. This phenomenon has been known historic...
Amyloid β influences the relationship between cortical thickness and vascular load [0.03%]
淀粉样蛋白β影响皮质厚度和血管负荷之间的关系
Thomas D Parker,David M Cash,Christopher A Lane et al.
Thomas D Parker et al.
Introduction: Cortical thickness has been proposed as a biomarker of Alzheimer's disease (AD)- related neurodegeneration, but the nature of its relationship with amyloid beta (Aβ) deposition and white matter hyperintensi...