Associations between serum uric acid levels and risk of dementia in community-dwelling older adults [0.03%]
血尿酸水平与社区居住老年人认知障碍风险的相关性研究
Md Golam Rabbani,Sheikh M Alif,Joanne Ryan et al.
Md Golam Rabbani et al.
Introduction: Evidence on the association between serum uric acid (SUA) and dementia risk is inconsistent, and prospective data in older adults are limited. This study examined associations of SUA levels and trajectories ...
Medical comorbidities of patients receiving amyloid-targeting treatments in a memory clinic [0.03%]
记忆门诊接受淀粉样蛋白靶向治疗的患者的医疗合并症
William J B Powell,Suzanne E Schindler,Martí Jiménez-Mausbach et al.
William J B Powell et al.
Introduction: Trials of amyloid-targeting treatments (ATTs) for early symptomatic Alzheimer's disease (AD) enrolled selected patients with minimal medical comorbidities. We investigated whether real-world memory clinic pa...
Quantification of global gray matter amyloid-β plaque from 18F-Florbetaben PET/MRI and correlation to BAPL score in patients with cognitive impairment [0.03%]
基于18F-氟乙苯基苯胺的正电子发射断层扫描/磁共振成像技术定量检测认知障碍患者脑灰质淀粉样β斑块并分析其与Braak淀粉样蛋白负荷评分的相关性
Adam Farag,Seyed Ali Mirshahvalad,Claudia Ortega et al.
Adam Farag et al.
Introduction: Multiple standardized uptake value ratio (SUVR) and Centiloid (CL) thresholds exist for amyloid‑β (Aβ) positron emission tomography (PET) to classify scans as negative or positive, yet none reliably strat...
Benchmarking privacy and utility in synthetic tabular cohorts for Alzheimer's disease research [0.03%]
阿尔茨海默病研究中合成数据集的隐私与效用评估基准测试
Filip Winzell,Ida Arvidsson,Niels Christian Overgaard et al.
Filip Winzell et al.
Introduction: The scarcity of large, clinically relevant cohorts is becoming a bottleneck in Alzheimer's disease (AD) research, as their sensitive nature makes open data sharing difficult. Privacy-preserving synthetic dat...
Navigation performance in virtual reality-based cognitive assessment games as a candidate digital cognitive marker of hippocampal vulnerability: a scoping review [0.03%]
基于虚拟现实的认知评估游戏中导航表现作为海马脆弱性的候选数字认知标志物的定位综述研究
Yesoda Bhargava,Saumya Tripathi,Veeky Baths et al.
Yesoda Bhargava et al.
Virtual reality-based cognitive assessment games (VR-CAGs) are an emerging digital paradigm in dementia and Alzheimer's disease research. Although multiple studies report correlations between VR-CAG performance and standard neuropsychologic...
Semaglutide attenuates a proteomics-based dementia risk signature in older adults with overweight or obesity and cardiovascular disease without diabetes: A post hoc analysis of the SELECT phase 3 trial [0.03%]
司美格鲁肽通过蛋白质组学基于的痴呆风险标志物减轻超重或肥胖且伴有心血管疾病的非糖尿病老年人的认知衰退：SELECT三期试验的事后分析
Martí Jiménez-Mausbach,Betty M Tijms,Clare Paterson et al.
Martí Jiménez-Mausbach et al.
Introduction: Plasma proteomics detect multi-pathway biological changes preceding dementia onset. The Dementia SomaSignal Test (dSST) is a validated 25-protein score predicting 5- and 20-year all-cause dementia risk. Prec...
Parallel neuroinflammatory pathways to cerebrovascular burden and amyloid beta in Alzheimer's disease [0.03%]
阿尔茨海默病并行的神经炎症途径与脑血管负担和β淀粉样蛋白的关系
Batool Rizvi,Jenna N Adams,Alison Bamford et al.
Batool Rizvi et al.
Introduction: Upstream neuroinflammation plays an important role in Alzheimer's disease (AD) but remains poorly understood. We tested whether two distinct neuroinflammatory markers are associated with cerebrovascular burd...
Arterial stiffness and risk of dementia in late life: The ARIC neurocognitive study [0.03%]
动脉僵硬度与晚年痴呆症风险的关系：ARIC神经认知研究
Jenna Barbee,James Russell Pike,Jingkai Wei et al.
Jenna Barbee et al.
Introduction: Associations of arterial stiffness, measured through pulse wave velocity (PWV), with incident dementia may be driven by age-related structural changes to the arterial wall or by elevated blood pressure. ...
Management of multimorbidity in the midst of cognitive decline through clinical decision-support software [0.03%]
临床决策支持软件在认知能力下降情况下的多发病管理
Mark C Zelek,John Q Walker nd,Marwan N Sabbagh
Mark C Zelek
Introduction: Multimorbidity - the coexistence of multiple chronic conditions - is common among older adults with cognitive impairment but is rarely addressed in an integrated manner. ...
Role of sex and ethnicity in the relationships among physical activity, cognition, and AD biomarkers in the HABS-HD cohort [0.03%]
种族和性别在HABS-HD队列中身体活动、认知与AD生物标志物之间的关系中的作用
Jansie H Nel,Joel S Burma,Tamara S Bodnar et al.
Jansie H Nel et al.
Introduction: Dementia prevalence is rising with population aging, disproportionately affecting females and ethnically diverse groups. Physical activity (PA) may mitigate age-related cognitive and brain decline; sex- and ...