Intersecting vulnerabilities: race, depression, and white matter hypointensity burden in aging [0.03%]
交织的脆弱性：种族，抑郁和衰老中的低白质负担
Farooq Kamal,Roqaie Moqadam,Cassandra Morrison et al.
Farooq Kamal et al.
Introduction: White matter hypointensities (WMHs) are associated with cognitive decline and dementia. However, it remains unknown how race, ethnicity, and depression influence WMHs. This study examined the interactive eff...
Mid-life cardiorespiratory fitness and risk of late-onset dementia incidence [0.03%]
中年心肺耐力与晚年痴呆发病风险的关系
Camilla A Wiklund,Rui Wang,Magnus Lindwall et al.
Camilla A Wiklund et al.
Introduction: Cardiorespiratory fitness (CRF) is linked to dementia risk, but moderating factors remain unclear. This study examined how and when CRF in adulthood is associated with late-onset dementia (> 65 years) and wh...
Population disparities in Alzheimer's disease: A systematic review of fluid and neuroimaging biomarkers [0.03%]
阿尔茨海默病的群体差异：液体和神经影像生物标志物的系统评价
Linus Kpelle,Ansumana Bockarie,Maxwell Hubert Antwi et al.
Linus Kpelle et al.
Alzheimer's disease manifests differently across ancestral groups, with African populations showing distinct fluid biomarker levels, neuroimaging patterns, and post mortem pathology. These differences may compromise diagnostic accuracy and ...
Interchangeability of blood-based biomarkers and PET to identify Alzheimer's disease pathology [0.03%]
血液生物标志物与正电子发射断层扫描在识别阿尔茨海默病病理改变中的互换性
Jian Wang,Joel B Braunstein,Robin Wolz et al.
Jian Wang et al.
Introduction: Establishing interchangeability between blood biomarkers and amyloid-positron emission tomography (PET) could help identify patients who would benefit from novel amyloid-targeting therapies for Alzheimer's d...
Considerations for disclosing Alzheimer's disease risk and biomarker results in a Pueblo community in Southwest United States [0.03%]
在美国西南部普韦布洛社区披露阿尔茨海默病风险和生物标志物结果的考虑因素
Sephira Ryman,Katherine Edwards,Tamar Ginossar et al.
Sephira Ryman et al.
Background: Biomarkers and Alzheimer's disease (AD) risk disclosure may help reduce disparities in dementia diagnosis and care in Indigenous communities. ...
Willing, but unequally: Indigenous identity influences participation in Alzheimer's disease biomarker research in Chile [0.03%]
愿意，但不平等：土著身份影响智利阿尔茨海默病生物标志物研究的参与度
José M Aravena,Rodrigo Saguez,Moisés H Sandoval et al.
José M Aravena et al.
Introduction: This study aimed to compare the willingness to use Alzheimer's disease (AD) predictive-diagnostic procedures between Mapuche (Indigenous) and non-Indigenous older adults in Chile. ...
Human and large language model judgments of cognitive impairment from language: An explainable artificial intelligence approach [0.03%]
基于可解释人工智能的方法：从语言判断认知障碍的机器与人类评价模型研究
Maya Zadok,Lotem Peled-Cohen,Nitay Calderon et al.
Maya Zadok et al.
Introduction: We examine how non-expert humans (young adults unfamiliar with dementia) and large language models (LLMs) perceive dementia in transcribed texts-recognizing signs that may indicate cognitive decline. Human p...
Beyond black-box AI: Interpretable hybrid systems for dementia care [0.03%]
超越黑盒人工智能：用于痴呆症护理的可解释混合系统
Matthew J Y Kang,Wenli Yang,Monica R Roberts et al.
Matthew J Y Kang et al.
Foundation models (FMs) are entering Alzheimer's disease and related dementias (ADRD), yet bedside impact remains limited. We analyze the interpretability and reliability gaps that impede adoption, including opaque inference, hallucinations...
Biological sex and bilingualism: Its impact on risk and resilience for dementia [0.03%]
生物性别与双语主义：其对痴呆症风险和适应能力的影响
Noelia Calvo,Natalie Phillips,Ellen Bialystok et al.
Noelia Calvo et al.
Introduction: The relationship between biological sex, considered a risk factor for Alzheimer's disease (AD), and bilingualism, a resilience factor, is unclear. We assessed this relationship in 335 individuals with mild c...
Modeling contributions of cognition and apathy to functional impairment in younger-onset dementia [0.03%]
年轻发病痴呆患者认知功能和淡漠对日常生活能力影响的建模分析
Samuel L Warren,Rebekah M Ahmed,Olivier Piguet et al.
Samuel L Warren et al.
Introduction: Overlaps in symptom presentation limits the capacity to predict functional impairment and future care needs in younger-onset dementia syndromes. ...