Digital cognition plus plasma p-Tau217 and Aβ42/40 powerfully predict Alzheimer's progression [0.03%]
数字认知加上血浆p-Tau217和Aβ42/40强大地预测阿尔茨海默病的进展
Ahmet Begde,Yi Yang,Vanessa Raymont et al.
Ahmet Begde et al.
Introduction: Alzheimer's disease is characterized by amyloid-β (Aβ) and tau accumulation. Identifying individuals with rapid proteinopathy progression is crucial for timely intervention and trial enrichment. ...
Plasma p-tau217 for Alzheimer's disease diagnosis: a memory clinic implementation approach [0.03%]
适用于阿尔茨海默病诊断的血浆p-tau217检测在记忆门诊中的实施方法
Giorgia Brodini,Fausto Roveta,Alberto Mario Chiarandon et al.
Giorgia Brodini et al.
Introduction: Plasma phosphorylated tau at threonine 217 (p-tau217) has shown excellent diagnostic performance for Alzheimer's disease (AD), yet real-world validation and implementation pathways remain limited. This study...
Increased risk of infusion-related reactions switching between monoclonal antibodies for Alzheimer's disease: A case series [0.03%]
切换使用阿尔茨海默病单克隆抗体引起的输液反应风险增加：一系列病例报告
Ganesh Gopalakrishna,Cristina Tandoc,Pallavi Joshi
Ganesh Gopalakrishna
Introduction: Monoclonal antibodies (mAbs) targeting amyloid plaques are increasingly used in early Alzheimer's disease (AD). Infusion-related reactions (IRRs) are recognized class effects, yet little is known about their...
Association of majority versus minority first language multilingualism and socioeconomic status with cognition among older adults residing in India [0.03%]
在印度居住的老年人中，第一语言多语使用（多数语言 vs 少数语言）和社会经济地位与认知之间的关联
Iris M Strangmann,Pranali Khobragade,Emma Nichols et al.
Iris M Strangmann et al.
Introduction: Multilingualism has been proposed as a protective factor against cognitive aging, but its effects are often intertwined with socioeconomic and sociolinguistic contexts, particularly whether an individual's f...
Autonomic dysfunction and hypothalamic atrophy in frontotemporal dementia and primary psychiatric disorders [0.03%]
额颞叶痴呆和原发性精神疾病的自主神经功能障碍和下丘脑萎缩
Yannick S S Timar,Marie-Paule Emilie van Engelen,Vikram Venkatraghavan et al.
Yannick S S Timar et al.
Introduction: Evidence suggests that autonomic symptoms in frontotemporal dementia (FTD) may relate to hypothalamic pathology. We investigated (1) autonomic symptoms in FTD, primary psychiatric disorders (PPD), and contro...
Bilingualism was not associated with a cognitive advantage among older Mexican adults [0.03%]
双语不会给墨西哥老年人带来认知优势
Lily Kamalyan,Kayle Karcher,Sarah Petrosyan et al.
Lily Kamalyan et al.
Introduction: We examined whether bilingualism was associated with a cognitive advantage among older urban- or rural-dwelling Mexican adults. Methods: ...
Initial real-world experience with lecanemab prescribing patterns in Japan: The Longevity Improvement & Fair Evidence (LIFE) Study [0.03%]
仑卡奈单抗在日本的初始真实世界用药经验：长寿改善与公平证据（LIFE）研究
Kengo Kawaguchi,Megumi Maeda,Futoshi Oda et al.
Kengo Kawaguchi et al.
Introduction: Lecanemab, an anti-amyloid-beta antibody, is approved in over 40 countries. Patient demographic data exist for the US but are limited elsewhere. This study examined early real-world lecanemab use in Japan. ...
Web-based LAS-FNAME and blood biomarkers in autosomal dominant Alzheimer's disease [0.03%]
基于网络的LAS-FNAME和血液生物标志物在常染色体显性阿尔茨海默病中的作用
Christopher Gonzalez Corona,Paula Ospina Lopera,Meredith C Rowe et al.
Christopher Gonzalez Corona et al.
Introduction: This study examined whether performance on the web-based Latin American Spanish Face-Name Associative Memory Exam (LAS-FNAME), an associative memory test, is associated with plasma biomarkers in autosomal do...
Neuropsychiatric symptoms relate to everyday functioning as reported by cognitively unimpaired older adults and their study partners [0.03%]
神经精神症状与认知功能未受损老年人及其研究伙伴报告的日常生活能力的关系
Grace J Ma,Mark A Dubbelman,Catherine E Munro et al.
Grace J Ma et al.
Introduction: Neuropsychiatric symptoms and changes in everyday functioning emerge early in Alzheimer's disease, but the relationships among these signs are rarely considered. We aimed to examine associations between neur...
Dana Pourzinal,Deborah Brooks,John D O&#x;Sullivan et al.
Dana Pourzinal et al.
For people living with Parkinson's disease (PD), cognitive impairment is a salient concern. The cumulative risk of mild cognitive impairment and dementia increases as the disease progresses, which contributes to loss of functional independe...