Refining cognitive dispersion metrics for brain-behavior prediction in aging and mild cognitive impairment [0.03%]
用于衰老和轻度认知障碍的脑-行为预测的认知弥散指标的改进
Truc Tran Thanh Nguyen,Yu-Ling Chang
Truc Tran Thanh Nguyen
Introduction: This study addresses three key issues in the standardization of cognitive dispersion: its operationalizations though intra-individual standard deviation (ISD) versus coefficient of variation (CoV), its relia...
A fovea-centered retinal signature linked to plasma biomarkers in prodromal Alzheimer's disease [0.03%]
与前驱期阿尔茨海默病血浆生物标志物相关的以中央凹为中心的视网膜特征
Sara Teijeira-Portas,Ane Murueta-Goyena,Aitor Zamora-Otaola et al.
Sara Teijeira-Portas et al.
Introduction: Blood biomarkers detect Alzheimer's disease (AD), but tissue correlates of early tau pathology and glial activation remain unclear. We investigated whether multimodal retinal measures capture a focal prodrom...
Mid- and late-life depression increases risk of Alzheimer's disease and related dementias in veterans [0.03%]
中晚期抑郁症增加退伍军人患阿尔茨海默病及相关痴呆症的风险
Lay Kodama,Elizabeth Valocchi,Catherine Chanfreau-Coffinier et al.
Lay Kodama et al.
Introduction: Using 20-year data from the Veterans Health Administration's electronic health record, we explored associations between mid- and late-life depression with incident Alzheimer's disease and related dementias (...
Investigating the amyloid-tau-neurodegeneration framework in Alzheimer's disease using semi-supervised multimodal imaging data fusion [0.03%]
基于半监督多模态成像数据融合的阿尔茨海默病中淀粉样蛋白Tau蛋白神经退行性框架研究
You Cheng,Adrián Medina,Cole Korponay et al.
You Cheng et al.
Introduction: Alzheimer's disease (AD) heterogeneity complicates diagnosis and prognosis. Uncovering amyloid-tau-neurodegeneration (A-T-N) patterns may improve diagnostic prediction. ...
Eligibility for anti-amyloid treatment in a multiethnic community-based study [0.03%]
基于社区的多民族队列中淀粉样蛋白靶向治疗的纳入标准
Lydia Trudel,Joseph Therriault,Arthur C Macedo et al.
Lydia Trudel et al.
Introduction: The approval of anti-amyloid monoclonal antibodies (mAbs), including lecanemab and donanemab, represents a significant advance in disease-modifying therapies (DMTs) for early Alzheimer's disease (AD). While ...
Life's Essential 8 and cerebrovascular disease among Hispanic/Latino adults: findings from the Hispanic Community Health Study/Study of Latinos and Study of Latinos-Investigation of Neurocognitive Aging magnetic resonance imaging cohort [0.03%]
生命中重要的八件事与拉丁裔成年人的脑血管疾病之间的关系：来自《拉丁裔社区健康研究》和《拉丁裔研究》中的神经认知衰老磁共振成像队列的研究结果
Freddie Márquez,Wassim Tarraf,Sayaka Kuwayama et al.
Freddie Márquez et al.
Introduction: Better cardiovascular health (CVH) is associated with better cognitive function, but limited data exist on its association with cerebrovascular disease (CVD) burden using the Life's Essential 8 (LE8) metric,...
Perceptions of the use of biomarkers for Alzheimer's disease diagnosis: A systematic review and synthesis of the qualitative literature [0.03%]
阿尔茨海默病诊断中生物标志物使用看法的系统评价和质性文献综合
Jemma Hazan,Mitchell Mealing,Emma Mittelman et al.
Jemma Hazan et al.
Biomarker investigations are increasingly used in the diagnostic assessment of Alzheimer's disease (AD), yet stakeholder perceptions and implementation factors remain underexplored. No systematic qualitative synthesis exists on these views....
Age-related macular degeneration severity and risk of Alzheimer's disease in older adults in a prospective, community-based cohort study [0.03%]
基于社区的前瞻性队列研究中年龄相关性黄斑变性和阿尔茨海默病发病风险的关系
Chloe A Krakauer,Luke Reilly,Yu-Ru Su et al.
Chloe A Krakauer et al.
Introduction: Age-related macular degeneration (AMD) is associated with higher risk of Alzheimer's disease (AD), but how AD risk changes as AMD progresses remains unclear. ...
APOE ε4, modifiable risk factors, and dementia in community-based older Japanese adults [0.03%]
基于社区的老年日本人中APOE ε4、可以改变的危险因素与痴呆的关系
Masaya Kumamoto,Toshiharu Ninomiya,Yoshihiko Furuta et al.
Masaya Kumamoto et al.
Introduction: Apolipoprotein E (APOE) ε4 is a major genetic risk factor for dementia. We examined whether APOE ε4 genotype modified the associations between a modifiable risk factor (mRF) score and dementia in older Jap...
Lecanemab and amyloid-related imaging abnormalities: Real-world data from a single center experience [0.03%]
莱卡内单抗与淀粉样蛋白相关影像学异常：单一中心的真实世界数据体验
Alexander Wallace,Oliver Zhou,Minh-Nguyet Hoang et al.
Alexander Wallace et al.
Introduction: Lecanemab has demonstrated both safety and efficacy in clinical trials; however, routine clinical data are sparse. We contribute to the growing body of real-world safety data, with a special focus on amyloid...